Structure information

FP receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8XJK

SPECIES

Homo sapiens

RESOLUTION

2.630

PREFERRED CHAIN

R

REFERENCE

PUBLICATION DATE

Feb. 28, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
cloprostenol S33 1.39x39 TM1 polar (hydrogen bond)
cloprostenol S33 1.39x39 TM1 Van der Waals
cloprostenol F36 1.42x42 TM1 Van der Waals
cloprostenol M37 1.43x43 TM1 Van der Waals
cloprostenol G80 2.53x53 TM2 Van der Waals
cloprostenol H81 2.54x54 TM2 Van der Waals
cloprostenol H81 2.54x54 TM2 polar (hydrogen bond)
cloprostenol N84 2.57x57 TM2 Van der Waals
cloprostenol G85 2.58x58 TM2 Van der Waals
cloprostenol A88 2.61x61 TM2 Van der Waals
cloprostenol A88 2.61x61 TM2 hydrophobic
cloprostenol Y92 2.65x65 TM2 polar (hydrogen bond)
cloprostenol Y92 2.65x65 TM2 Van der Waals
cloprostenol M115 3.32x32 TM3 hydrophobic
cloprostenol M115 3.32x32 TM3 Van der Waals
cloprostenol S118 3.35x35 TM3 Van der Waals
cloprostenol S118 3.35x35 TM3 polar (hydrogen bond with backbone)
cloprostenol G119 3.36x36 TM3 Van der Waals
cloprostenol T184 ECL2 polar (hydrogen bond)
cloprostenol T184 ECL2 Van der Waals
cloprostenol W185 ECL2 Van der Waals
cloprostenol W185 ECL2 hydrophobic
cloprostenol F187 45.51x51 ECL2 hydrophobic
cloprostenol F187 45.51x51 ECL2 Van der Waals
cloprostenol F205 5.41x41 TM5 hydrophobic
cloprostenol W262 6.48x48 TM6 Van der Waals
cloprostenol W262 6.48x48 TM6 hydrophobic
cloprostenol F265 6.51x51 TM6 aromatic (face-to-edge)
cloprostenol F265 6.51x51 TM6 Van der Waals
cloprostenol L287 7.36x35 TM7 Van der Waals
cloprostenol L290 7.39x38 TM7 hydrophobic
cloprostenol L290 7.39x38 TM7 Van der Waals
cloprostenol R291 7.40x39 TM7 polar (charge-assisted hydrogen bond)
cloprostenol A293 7.42x41 TM7 hydrophobic
cloprostenol A293 7.42x41 TM7 Van der Waals
cloprostenol T294 7.43x42 TM7 polar (hydrogen bond)
cloprostenol T294 7.43x42 TM7 Van der Waals
cloprostenol Q297 7.46x46 TM7 polar (hydrogen bond)
cloprostenol Q297 7.46x46 TM7 Van der Waals

Ligands

cloprostenol

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Residue Diagrams

S N S L I G V T M F I V S F F V 1 S G L V I T D F F G H L I N G A I A V F 2 V S G L L L P C L G S F V M C I G F I S 3 V K M M L S G V C L F A V F I A L L P I 4 I A N C L L S V G L A L L G L F S F L L 5 L A I M C V S C I C W S P F L V T M A N 6 W P D L I Q N W T A M R L A F L T T E 7
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ICL1 K S K ICL1ECL1 K E W I R F D Q S ECL1ICL2 P I F H S T K I ICL2ECL2 H R D Y K I Q A S R T W C F Y N T E D I K ECL2ICL3 Q H R Q G ICL3ECL3 G N H S L E ECL3N-term M S M N N S K Q L V S P A A A L L S N T T C Q T E N R L S N-termC-term I S L H I W E L S S I K N S L K V A A I S E S P V A E K S A S T C-term V F F S V I F M T V G I L S N S L A I A I L M K A Y Q R F R Q A S F L L L A S G L V I T D F F G H L I N G A I A V F V Y A S D N V L C S I F G I C M V F S G L C P L L L G S V M A I E R C I G V T K T S K H V K M M L S G V C L F A V F I A L L P I L G D W E D R F Y L L L F S F L G L L A L G V S L L C N A I T G I T L L R V K F K S Q R S H H L E M V I Q L L A I M C V S C I C W S P F L V T M A N I G I N T C E T T L F A L R M A T W N Q I L D P W V Y I L L R K A L Y K C C G V L K N L A S Q V H V
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Residue Table


GPCRdb(A)
GPCRdb(A)
FP receptor
TM1
1x39 1.39x39 S33
1x42 1.42x42 F36
1x43 1.43x43 M37
TM2
2x53 2.53x53 G80
2x54 2.54x54 H81
2x57 2.57x57 N84
2x58 2.58x58 G85
2x61 2.61x61 A88
2x65 2.65x65 Y92
TM3
3x32 3.32x32 M115
3x35 3.35x35 S118
3x36 3.36x36 G119
ECL2
45x51 45.51x51 F187
TM5
5x41 5.41x41 F205
TM6
6x48 6.48x48 W262
6x51 6.51x51 F265
TM7
7x35 7.36x35 L287
7x38 7.39x38 L290
7x39 7.40x39 R291
7x41 7.42x41 A293
7x42 7.43x42 T294
7x46 7.46x46 Q297