Structure information

FP receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8XJM

SPECIES

Homo sapiens

RESOLUTION

2.850

PREFERRED CHAIN

R

REFERENCE

10.1016/J.CELREP.2024.113893

PUBLICATION DATE

Feb. 28, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
latanoprost (free acid form) S33 1.39x39 TM1 polar (hydrogen bond with backbone)
latanoprost (free acid form) S33 1.39x39 TM1 Van der Waals
latanoprost (free acid form) S33 1.39x39 TM1 polar (hydrogen bond)
latanoprost (free acid form) F36 1.42x42 TM1 Van der Waals
latanoprost (free acid form) M37 1.43x43 TM1 Van der Waals
latanoprost (free acid form) G80 2.53x53 TM2 Van der Waals
latanoprost (free acid form) H81 2.54x54 TM2 polar (hydrogen bond)
latanoprost (free acid form) H81 2.54x54 TM2 Van der Waals
latanoprost (free acid form) G85 2.58x58 TM2 Van der Waals
latanoprost (free acid form) A88 2.61x61 TM2 Van der Waals
latanoprost (free acid form) A88 2.61x61 TM2 hydrophobic
latanoprost (free acid form) Y92 2.65x65 TM2 polar (hydrogen bond)
latanoprost (free acid form) Y92 2.65x65 TM2 Van der Waals
latanoprost (free acid form) M115 3.32x32 TM3 hydrophobic
latanoprost (free acid form) M115 3.32x32 TM3 Van der Waals
latanoprost (free acid form) S118 3.35x35 TM3 Van der Waals
latanoprost (free acid form) G119 3.36x36 TM3 Van der Waals
latanoprost (free acid form) T184 ECL2 Van der Waals
latanoprost (free acid form) T184 ECL2 polar (hydrogen bond)
latanoprost (free acid form) W185 ECL2 hydrophobic
latanoprost (free acid form) W185 ECL2 Van der Waals
latanoprost (free acid form) F187 45.51x51 ECL2 hydrophobic
latanoprost (free acid form) F205 5.41x41 TM5 Van der Waals
latanoprost (free acid form) F205 5.41x41 TM5 hydrophobic
latanoprost (free acid form) W262 6.48x48 TM6 Van der Waals
latanoprost (free acid form) W262 6.48x48 TM6 hydrophobic
latanoprost (free acid form) F265 6.51x51 TM6 aromatic (face-to-edge)
latanoprost (free acid form) F265 6.51x51 TM6 Van der Waals
latanoprost (free acid form) L287 7.36x35 TM7 Van der Waals
latanoprost (free acid form) L290 7.39x38 TM7 hydrophobic
latanoprost (free acid form) L290 7.39x38 TM7 Van der Waals
latanoprost (free acid form) R291 7.40x39 TM7 polar (charge-assisted hydrogen bond)
latanoprost (free acid form) T294 7.43x42 TM7 polar (hydrogen bond)
latanoprost (free acid form) T294 7.43x42 TM7 Van der Waals
latanoprost (free acid form) Q297 7.46x46 TM7 polar (hydrogen bond)
latanoprost (free acid form) Q297 7.46x46 TM7 Van der Waals

Ligands

latanoprost (free acid form)

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Residue Diagrams

S N S L I G V T M F I V S F F V 1 S G L V I T D F F G H L I N G A I A V F 2 V S G L L L P C L G S F V M C I G F I S 3 V K M M L S G V C L F A V F I A L L P I 4 I A N C L L S V G L A L L G L F S F L L 5 L A I M C V S C I C W S P F L V T M A N 6 W P D L I Q N W T A M R L A F L T T E 7
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ICL1 K S K ICL1ECL1 K E W I R F D Q S ECL1ICL2 P I F H S T K I ICL2ECL2 H R D Y K I Q A S R T W C F Y N T E D I K ECL2ICL3 Q H R Q G ICL3ECL3 G N H S L E ECL3N-term M S M N N S K Q L V S P A A A L L S N T T C Q T E N R L S N-termC-term I S L H I W E L S S I K N S L K V A A I S E S P V A E K S A S T C-term V F F S V I F M T V G I L S N S L A I A I L M K A Y Q R F R Q A S F L L L A S G L V I T D F F G H L I N G A I A V F V Y A S D N V L C S I F G I C M V F S G L C P L L L G S V M A I E R C I G V T K T S K H V K M M L S G V C L F A V F I A L L P I L G D W E D R F Y L L L F S F L G L L A L G V S L L C N A I T G I T L L R V K F K S Q R S H H L E M V I Q L L A I M C V S C I C W S P F L V T M A N I G I N T C E T T L F A L R M A T W N Q I L D P W V Y I L L R K A L Y K C C G V L K N L A S Q V H V
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Residue Table


GPCRdb(A)
GPCRdb(A)
FP receptor
TM1
1x39 1.39x39 S33
1x42 1.42x42 F36
1x43 1.43x43 M37
TM2
2x53 2.53x53 G80
2x54 2.54x54 H81
2x58 2.58x58 G85
2x61 2.61x61 A88
2x65 2.65x65 Y92
TM3
3x32 3.32x32 M115
3x35 3.35x35 S118
3x36 3.36x36 G119
ECL2
45x51 45.51x51 F187
TM5
5x41 5.41x41 F205
TM6
6x48 6.48x48 W262
6x51 6.51x51 F265
TM7
7x35 7.36x35 L287
7x38 7.39x38 L290
7x39 7.40x39 R291
7x42 7.43x42 T294
7x46 7.46x46 Q297