PDB
8XOF
Resolution
2.6 Å
Released
April 10, 2024
Receptor
GPER
Class
A
Species
Homo sapiens
Ligand
Lys05
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
Lys05 L137 3.32x32 TM3 hydrophobic
Lys05 W272 6.48x48 TM6 hydrophobic
Lys05 E275 6.51x51 TM6 polar (charge-assisted hydrogen bond)
Lys05 H282 6.58x58 TM6 Van der Waals
Lys05 H300 ECL3 aromatic (face-to-edge)
Lys05 H300 ECL3 polar (hydrogen bond)
Lys05 H300 ECL3 Van der Waals
Lys05 A301 ECL3 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R E K M ICL1ECL1 Y Y D I ECL1ICL2 A M R C S L F R ICL2ECL2 T D E A C F C F A D ECL2ICL3 H R G L R P R ICL3ECL3 P G A A P C ECL3N-term M D V T S Q A R G V G L E M Y P G T A Q P A A P N T T S P E L N L S H P L L G T A L A N G T G E L S N-termC-term T N L P A L N R F C H A A L K A V I P D S T E Q S D V R F S S A V C-term E H Q Q Y V I G L F L S C L Y T I F L F P I G F V G N I L I L V V N I S F T I P D L Y F I N L A V A D L I L V A D S L I E V F N L H E R A V L C T F M S L F L Q V N M Y S S V F F L T W M S F D R Y I A L A R T K H H A R L S C G L I W M A S V S A T L V P F T A V H L Q H V R E V Q W L E V T L G F I V P F A I I G L C Y S L I V R V L V R A H R R Q K A L R M I L A V V L V F F V C W L P E N V F I S V H L L Q R T Q K Q S F R H A H P L T G H I V N L A A F S N S C L N P L I Y S F L G E T L R L K F R D K Y I E Q
Helix box plot — Download: PNG | SVG I N G V F G I P F L F I T Y L C S L F L 1 I N L A V A D L I L V A D S L I E V F N 2 W T L F F V S S Y M N V Q L F L S M F T 3 A R L S C G L I W M A S V S A T L V P F 4 Y C L G I I A F P V I F G L T V E L W Q V 5 L A V V L V F F V C W L P E N V F I S V 6 L P N L C S N S F A A L N V I H G T L 7

GPCRdb(A)
GPCRdb(A)
GPER
TM3
3x32 3.32x32 L137
TM6
6x48 6.48x48 W272
6x51 6.51x51 E275
6x58 6.58x58 H282