Ligands
Function
Agonist
Allosteric agonist
Reference
| Ligand | Amino Acid | Generic Number | Segment | Interaction Type |
|---|---|---|---|---|
| Cholesterol | I62 | 2.57x57 | TM2 | hydrophobic |
| Cholesterol | S65 | 2.60x60 | TM2 | Van der Waals |
| Cholesterol | F76 | ECL1 | polar (hydrogen bond with backbone) | |
| Cholesterol | F76 | ECL1 | hydrophobic | |
| Cholesterol | F82 | 3.25x25 | TM3 | hydrophobic |
| Cholesterol | L85 | 3.28x28 | TM3 | hydrophobic |
| Cholesterol | T86 | 3.29x29 | TM3 | Van der Waals |
| Cholesterol | W89 | 3.32x32 | TM3 | hydrophobic |
| flufenamic acid | G104 | 3.47x47 | TM3 | Van der Waals |
| flufenamic acid | Y107 | 3.50x50 | TM3 | aromatic (edge-to-face) |
| flufenamic acid | Y107 | 3.50x50 | TM3 | hydrophobic |
| Cholesterol | F172 | 5.32x33 | TM5 | hydrophobic |
| Cholesterol | S176 | 5.36x37 | TM5 | Van der Waals |
| Cholesterol | I179 | 5.39x40 | TM5 | hydrophobic |
| Cholesterol | V180 | 5.40x41 | TM5 | hydrophobic |
| Cholesterol | S183 | 5.43x44 | TM5 | Van der Waals |
| Cholesterol | T184 | 5.44x45 | TM5 | hydrophobic |
| Cholesterol | I187 | 5.47x47 | TM5 | hydrophobic |
| flufenamic acid | S194 | 5.54x54 | TM5 | Van der Waals |
| flufenamic acid | F198 | 5.58x58 | TM5 | hydrophobic |
| flufenamic acid | F198 | 5.58x58 | TM5 | aromatic (edge-to-face) |
| flufenamic acid | L201 | 5.61x61 | TM5 | hydrophobic |
| flufenamic acid | I202 | 5.62x62 | TM5 | Van der Waals |
| flufenamic acid | V230 | 6.35x35 | TM6 | Van der Waals |
| flufenamic acid | F237 | 6.42x42 | TM6 | Van der Waals |
| Cholesterol | Y240 | 6.45x45 | TM6 | Van der Waals |
| Cholesterol | I262 | 7.35x34 | TM7 | hydrophobic |
| Cholesterol | S265 | 7.38x37 | TM7 | Van der Waals |
| Cholesterol | Q266 | 7.39x38 | TM7 | Van der Waals |
| Cholesterol | M268 | 7.41x40 | TM7 | hydrophobic |
| Cholesterol | G269 | 7.42x41 | TM7 | Van der Waals |
| flufenamic acid | H276 | 7.49x49 | TM7 | polar (hydrogen bond) |
| flufenamic acid | L280 | 7.53x53 | TM7 | Van der Waals |
| flufenamic acid | G283 | 7.56x56 | TM7 | Van der Waals |
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|
GPCRdb(A)
|
GPCRdb(A)
|
TAS2R14
|
|---|---|---|
| TM2 | ||
| 2x57 | 2.57x57 | I62 |
| 2x60 | 2.60x60 | S65 |
| TM3 | ||
| 3x25 | 3.25x25 | F82 |
| 3x28 | 3.28x28 | L85 |
| 3x29 | 3.29x29 | T86 |
| 3x32 | 3.32x32 | W89 |
| 3x47 | 3.47x47 | G104 |
| 3x50 | 3.50x50 | Y107 |
| TM5 | ||
| 5x40 | 5.39x40 | I179 |
| 5x41 | 5.40x41 | V180 |
| 5x44 | 5.43x44 | S183 |
| 5x45 | 5.44x45 | T184 |
| 5x47 | 5.47x47 | I187 |
| 5x54 | 5.54x54 | S194 |
| 5x58 | 5.58x58 | F198 |
| 5x61 | 5.61x61 | L201 |
| 5x62 | 5.62x62 | I202 |
| TM6 | ||
| 6x35 | 6.35x35 | V230 |
| 6x42 | 6.42x42 | F237 |
| 6x45 | 6.45x45 | Y240 |
| TM7 | ||
| 7x34 | 7.35x34 | I262 |
| 7x37 | 7.38x37 | S265 |
| 7x38 | 7.39x38 | Q266 |
| 7x40 | 7.41x40 | M268 |
| 7x41 | 7.42x41 | G269 |
| 7x49 | 7.49x49 | H276 |
| 7x53 | 7.53x53 | L280 |
| 7x56 | 7.56x56 | G283 |