PDB
8XQT
Resolution
2.9 Å
Released
July 10, 2024
Receptor
TAS2R14
Class
T2
Species
Homo sapiens
Ligand
Cholesterol
Function
Agonist
Reference
10.1038/S41586-024-07569-9

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Ligand Amino Acid Generic Number Segment Interaction Type
Cholesterol F82 3.25x25 TM3 polar (hydrogen bond with backbone)
Cholesterol F82 3.25x25 TM3 Van der Waals
Cholesterol L85 3.28x28 TM3 hydrophobic
Cholesterol L85 3.28x28 TM3 Van der Waals
Cholesterol T86 3.29x29 TM3 Van der Waals
Cholesterol T86 3.29x29 TM3 polar (hydrogen bond)
Cholesterol W89 3.32x32 TM3 hydrophobic
Cholesterol W89 3.32x32 TM3 Van der Waals
Cholesterol I179 5.39x40 TM5 hydrophobic
Cholesterol I179 5.39x40 TM5 Van der Waals
Cholesterol V180 5.40x41 TM5 Van der Waals
Cholesterol V180 5.40x41 TM5 hydrophobic
Cholesterol S183 5.43x44 TM5 Van der Waals
Cholesterol T184 5.44x45 TM5 Van der Waals
Cholesterol F188 5.48x48 TM5 hydrophobic
Cholesterol F188 5.48x48 TM5 Van der Waals
Cholesterol F247 6.52x52 TM6 Van der Waals
Cholesterol F248 6.53x53 TM6 hydrophobic
Cholesterol F248 6.53x53 TM6 Van der Waals
Cholesterol S265 7.38x37 TM7 Van der Waals
Cholesterol M268 7.41x40 TM7 hydrophobic
Cholesterol M268 7.41x40 TM7 Van der Waals
Cholesterol G269 7.42x41 TM7 Van der Waals

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ICL1 R K I ICL1ECL1 P A L F A ECL1ICL2 N F S N S I F L Y L K W ICL2ECL2 A S I N G Y R R N K T C S S D S S N F T R F S S L ECL2ICL3 K I S G D A S T K A ICL3ECL3 E E ECL3C-term G E P S G H K E F R E S S C-term M G G V I K S I F T F V L I V E F I I G N L G N S F I A L V N C I D W V K G S S V D R I L T A L A I S R I S L V W L I F G S W C V S V F F T E K M F R M L T N I W T V I N H F S V W L A T G L G T F Y F L K I A R V K K V V L V L L L V T S V F L F L N I A L I N I H I N I V L T S T V F I F I P F T L S L A M F L L L I F S M W K H R K K M Q H T V H R G V K S V I T F F L L Y A I F S L S F F I S V W T S E R L N L I I L S Q V M G M A Y P S C H S C V L I L G N K K S L S L R Y L R Q A V L L W M F K D
Helix box plot — Download: PNG | SVG S N G L N G I I F E V I L V F T F I S K 1 T A L A I S R I S L V W L I F G S W C V 2 G T A L W V S F H N I V T W I N T L M R 3 V L V L L L V T S V F L F L N I A L I N 4 F M A L S L T F P I F I F V T S T L V I 5 V I T F F L L Y A I F S L S F F I S V W 6 C S H C S P Y A M G M V Q S L I I L N 7

GPCRdb(A)
GPCRdb(A)
TAS2R14
TM3
3x25 3.25x25 F82
3x28 3.28x28 L85
3x29 3.29x29 T86
3x32 3.32x32 W89
TM5
5x40 5.39x40 I179
5x41 5.40x41 V180
5x44 5.43x44 S183
5x45 5.44x45 T184
5x48 5.48x48 F188
TM6
6x52 6.52x52 F247
6x53 6.53x53 F248
TM7
7x37 7.38x37 S265
7x40 7.41x40 M268
7x41 7.42x41 G269