Structure information

ETA receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8XVI

SPECIES

Homo sapiens

RESOLUTION

3.320

PREFERRED CHAIN

R

REFERENCE

10.1038/S41421-024-00705-9

PUBLICATION DATE

Aug. 28, 2024

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Ligand Interaction Browser

Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
ENDOTHELIN C69 N-term polar (hydrogen bond with backbone)
ENDOTHELIN C69 N-term Van der Waals
ENDOTHELIN Q72 N-term Van der Waals
ENDOTHELIN K140 2.64x63 TM2 polar (charge-assisted hydrogen bond)
ENDOTHELIN G144 ECL1 polar (hydrogen bond with backbone)
ENDOTHELIN G144 ECL1 Van der Waals
ENDOTHELIN W146 23.50x50 ECL1 Van der Waals
ENDOTHELIN W146 23.50x50 ECL1 hydrophobic
ENDOTHELIN P162 3.29x29 TM3 hydrophobic
ENDOTHELIN P162 3.29x29 TM3 Van der Waals
ENDOTHELIN Q165 3.32x32 TM3 Van der Waals
ENDOTHELIN K166 3.33x33 TM3 Van der Waals
ENDOTHELIN F229 ECL2 hydrophobic
ENDOTHELIN E230 ECL2 Van der Waals
ENDOTHELIN E230 ECL2 polar (hydrogen bond with backbone)
ENDOTHELIN Y231 ECL2 hydrophobic
ENDOTHELIN Y231 ECL2 Van der Waals
ENDOTHELIN T238 ECL2 Van der Waals
ENDOTHELIN M240 45.51x51 ECL2 Van der Waals
ENDOTHELIN L241 45.52x52 ECL2 Van der Waals
ENDOTHELIN L241 45.52x52 ECL2 hydrophobic
ENDOTHELIN Q252 5.35x36 TM5 Van der Waals
ENDOTHELIN K255 5.38x39 TM5 polar (charge-assisted hydrogen bond)
ENDOTHELIN R326 6.55x55 TM6 polar (charge-assisted hydrogen bond)
ENDOTHELIN K329 6.58x58 TM6 Van der Waals
ENDOTHELIN Y333 ECL3 polar (hydrogen bond)
ENDOTHELIN Y333 ECL3 Van der Waals
ENDOTHELIN E335 ECL3 Van der Waals
ENDOTHELIN R340 7.24x23 TM7 polar (charge-assisted hydrogen bond)
ENDOTHELIN L348 7.32x31 TM7 hydrophobic
ENDOTHELIN L348 7.32x31 TM7 Van der Waals
ENDOTHELIN D351 7.35x34 TM7 Van der Waals
ENDOTHELIN Y352 7.36x35 TM7 polar (hydrogen bond)
ENDOTHELIN Y352 7.36x35 TM7 Van der Waals

Ligands

ENDOTHELIN

3D interaction viewer Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.


Residue Diagrams

A N G V M G V I F I T C S I V T N I Y K 1 A S L A L G D L I Y V I V D L P I N V F K 2 A C L N L V T I G V S S K Q L F P F L K 3 T A I E I V S I W I L S F I L A I P E 4 Y F I A T C V L P M C F Y F G F L W W D K 5 F C L V V I F A L C W F P L H L S R I L 6 I P N I C S N M T A L N I G I Y D M L 7
Download: PNG | SVG
ICL1 K C M R N ICL1ECL1 G R W P F D H ECL1ICL2 W S R V Q G I G ICL2ECL2 V M V P F E Y R G E Q H K T C M L N A T ECL2ICL3 L R I A L ICL3ECL3 N E M D K N ECL3N-term M E T L C L R A S F W L A L V G C V I S D N P E R Y S T N L S N H V D D F T T F R G T E L S F L V T T H Q P T N L V L P S N G S M H N Y C N-termC-term C C Y Q S K S L M T S V P M N G T S I Q W K N H D Q N N H N T D R S S H K D S M N C-term P Q Q T K I T S A F K Y I N T V I S C T I F I V G M V G N A T L L R I I Y Q N G P N A L I A S L A L G D L I Y V V I D L P I N V F K L L A N D F G V F L C K L F P F L Q K S S V G I T V L N L C A L S V D R Y R A V A S I P L V T A I E I V S I W I L S F I L A I P E A I G F S K F M E F Y Q D V K D W W L F G F Y F C M P L V C T A I F Y T L M T C E M L N R R N G S S E H L K Q R R E V A K T V F C L V V I F A L C W F P L H L S R I L K K T V Y R C E L L S F L L L M D Y I G I N L A T M N S C I N P I A L Y F V S K K F Q S F K N C C L C C
Download: PNG | SVG

Residue Table


GPCRdb(A)
GPCRdb(A)
ETA receptor
TM2
2x63 2.64x63 K140
ECL1
23x50 23.50x50 W146
TM3
3x29 3.29x29 P162
3x32 3.32x32 Q165
3x33 3.33x33 K166
ECL2
45x51 45.51x51 M240
45x52 45.52x52 L241
TM5
5x36 5.35x36 Q252
5x39 5.38x39 K255
TM6
6x55 6.55x55 R326
6x58 6.58x58 K329
TM7
7x23 7.24x23 R340
7x31 7.32x31 L348
7x34 7.35x34 D351
7x35 7.36x35 Y352