PDB
8XVU
Resolution
3.1 Å
Released
Jan. 15, 2025
Receptor
CXCR2
Class
A
Species
Homo sapiens
Ligand
CXCL2
Function
Agonist
Reference
10.1016/J.MOLCEL.2025.01.024

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Ligand Amino Acid Generic Number Segment Interaction Type
CXCL2 L33 N-term hydrophobic
CXCL2 D35 N-term polar (charge-assisted hydrogen bond)
CXCL2 D35 N-term polar (hydrogen bond with backbone)
CXCL2 A36 N-term hydrophobic
CXCL2 A36 N-term Van der Waals
CXCL2 A37 N-term Van der Waals
CXCL2 P38 N-term Van der Waals
CXCL2 P38 N-term hydrophobic
CXCL2 C39 N-term Van der Waals
CXCL2 S43 N-term Van der Waals
CXCL2 K48 1.32x32 TM1 polar (charge-assisted hydrogen bond)
CXCL2 K108 2.64x64 TM2 Van der Waals
CXCL2 V187 ECL2 Van der Waals
CXCL2 V187 ECL2 hydrophobic
CXCL2 S189 ECL2 polar (hydrogen bond)
CXCL2 S190 ECL2 polar (hydrogen bond)
CXCL2 N191 ECL2 polar (hydrogen bond)
CXCL2 V192 ECL2 hydrophobic
CXCL2 V192 ECL2 Van der Waals
CXCL2 S193 ECL2 Van der Waals
CXCL2 S193 ECL2 polar (hydrogen bond with backbone)
CXCL2 S193 ECL2 polar (hydrogen bond)
CXCL2 Y197 45.51x51 ECL2 hydrophobic
CXCL2 Y197 45.51x51 ECL2 Van der Waals
CXCL2 N202 ECL2 Van der Waals
CXCL2 T204 5.31x32 TM5 Van der Waals
CXCL2 R208 5.35x36 TM5 polar (charge-assisted hydrogen bond)
CXCL2 R212 5.39x40 TM5 Van der Waals
CXCL2 D274 6.58x58 TM6 polar (charge-assisted hydrogen bond)
CXCL2 R278 6.62x62 TM6 polar (charge-assisted hydrogen bond)
CXCL2 E284 ECL3 Van der Waals
CXCL2 T285 7.24x23 TM7 Van der Waals
CXCL2 R289 7.28x27 TM7 polar (charge-assisted hydrogen bond)
CXCL2 I292 7.31x30 TM7 Van der Waals
CXCL2 D293 7.32x31 TM7 polar (charge-assisted hydrogen bond)
CXCL2 L296 7.35x34 TM7 Van der Waals

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ICL1 R V G R ICL1ECL1 G W I F ECL1ICL2 A T R T L T Q K R Y ICL2ECL2 R T V Y S S N V S P A C Y E D M G N ECL2ICL3 H M G ICL3ECL3 V I Q E ECL3N-term M E D F N M E S D S F E D F W K G E D L S N Y S Y S S T L P P F L L D A A P C E P E S L N-termC-term G L I S K D S L P K D S R P S F V G S S S G H T S T T L C-term E I N K Y F V V I I Y A L V F L L S L L G N S L V M L V I L Y S S V T D V Y L L N L A L A D L L F A L T L P I W A A S K V N G T F L C K V V S L L K E V N F Y S G I L L L A C I S V D R Y L A I V H L V K F I C L S I W G L S L L L A L P V L L F R N T A N W R M L L R I L P Q S F G F I V P L L I M L F C Y G F T L R T L F K A Q K H R A M R V I F A V V L I F L L C W L P Y N L V L L A D T L M R T Q T C E R R N H I D R A L D A T E I L G I L H S C L N P L I Y A F I G Q K L L K H F R H G I L A I
Helix box plot — Download: PNG | SVG S N G L L S L L F V L A Y I I V V F Y K 1 L N L A L A D L L F A L T L P I W A A S 2 C A L L L I G S Y F N V E K L L S V V K 3 V K F I C L S I W G L S L L L A L P V 4 Y C F L M I L L P V I F G F S Q P L I R L 5 F A V V L I F L L C W L P Y N L V L L A 6 L P N L C S H L I G L I E T A D L A R 7

GPCRdb(A)
GPCRdb(A)
CXCR2
TM1
1x32 1.32x32 K48
TM2
2x64 2.64x64 K108
ECL2
45x51 45.51x51 Y197
TM5
5x32 5.31x32 T204
5x36 5.35x36 R208
5x40 5.39x40 R212
TM6
6x58 6.58x58 D274
6x62 6.62x62 R278
TM7
7x23 7.24x23 T285
7x27 7.28x27 R289
7x30 7.31x30 I292
7x31 7.32x31 D293
7x34 7.35x34 L296