PDB
8XWV
Resolution
3.1 Å
Released
Jan. 22, 2025
Receptor
CXCR2
Class
A
Species
Homo sapiens
Ligand
Function
CXCL1
Agonist
Reference
10.1016/J.MOLCEL.2025.01.024

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Ligand Amino Acid Generic Number Segment Interaction Type
CXCL1 A36 N-term hydrophobic
CXCL1 A37 N-term Van der Waals
CXCL1 P38 N-term hydrophobic
CXCL1 C39 N-term polar (hydrogen bond with backbone)
CXCL1 S43 N-term polar (hydrogen bond)
CXCL1 S107 2.63x63 TM2 Van der Waals
CXCL1 K108 2.64x64 TM2 Van der Waals
CXCL1 V109 2.65x65 TM2 Van der Waals
CXCL1 N110 2.66x66 TM2 Van der Waals
CXCL1 G111 23.49x49 ECL1 Van der Waals
CXCL1 R185 ECL2 Van der Waals
CXCL1 V187 ECL2 hydrophobic
CXCL1 N191 ECL2 polar (hydrogen bond)
CXCL1 V192 ECL2 hydrophobic
CXCL1 S193 ECL2 polar (hydrogen bond)
CXCL1 S193 ECL2 polar (hydrogen bond with backbone)
CXCL1 A195 ECL2 Van der Waals
CXCL1 Y197 45.51x51 ECL2 hydrophobic
CXCL1 E198 45.52x52 ECL2 Van der Waals
CXCL1 D199 ECL2 Van der Waals
CXCL1 G201 ECL2 Van der Waals
CXCL1 N202 ECL2 Van der Waals
CXCL1 N203 5.30x31 TM5 Van der Waals
CXCL1 T204 5.31x32 TM5 Van der Waals
CXCL1 A205 5.32x33 TM5 hydrophobic
CXCL1 R208 5.35x36 TM5 polar (charge-charge)
CXCL1 R208 5.35x36 TM5 polar (hydrogen bond)
CXCL1 R212 5.39x40 TM5 polar (charge-charge)
CXCL1 D274 6.58x58 TM6 polar (charge-charge)
CXCL1 D274 6.58x58 TM6 polar (hydrogen bond)
CXCL1 R278 6.62x62 TM6 polar (charge-charge)
CXCL1 R278 6.62x62 TM6 polar (hydrogen bond)
CXCL1 E284 ECL3 hydrophobic
CXCL1 R289 7.28x27 TM7 Van der Waals
CXCL1 I292 7.31x30 TM7 Van der Waals
CXCL1 D293 7.32x31 TM7 polar (hydrogen bond)
CXCL1 D293 7.32x31 TM7 polar (charge-charge)
CXCL1 L296 7.35x34 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 R V G R ICL1ECL1 G W I F ECL1ICL2 A T R T L T Q K R Y ICL2ECL2 R T V Y S S N V S P A C Y E D M G N ECL2ICL3 H M G ICL3ECL3 V I Q E ECL3N-term M E D F N M E S D S F E D F W K G E D L S N Y S Y S S T L P P F L L D A A P C E P E S L N-termC-term G L I S K D S L P K D S R P S F V G S S S G H T S T T L C-term E I N K Y F V V I I Y A L V F L L S L L G N S L V M L V I L Y S S V T D V Y L L N L A L A D L L F A L T L P I W A A S K V N G T F L C K V V S L L K E V N F Y S G I L L L A C I S V D R Y L A I V H L V K F I C L S I W G L S L L L A L P V L L F R N T A N W R M L L R I L P Q S F G F I V P L L I M L F C Y G F T L R T L F K A Q K H R A M R V I F A V V L I F L L C W L P Y N L V L L A D T L M R T Q T C E R R N H I D R A L D A T E I L G I L H S C L N P L I Y A F I G Q K L L K H F R H G I L A I
Helix box plot — Download: PNG | SVG S N G L L S L L F V L A Y I I V V F Y K 1 L N L A L A D L L F A L T L P I W A A S 2 C A L L L I G S Y F N V E K L L S V V K 3 V K F I C L S I W G L S L L L A L P V 4 Y C F L M I L L P V I F G F S Q P L I R L 5 F A V V L I F L L C W L P Y N L V L L A 6 L P N L C S H L I G L I E T A D L A R 7

GPCRdb(A)
GPCRdb(A)
CXCR2
TM2
2x63 2.63x63 S107
2x64 2.64x64 K108
2x65 2.65x65 V109
2x66 2.66x66 N110
ECL1
23x49 23.49x49 G111
ECL2
45x51 45.51x51 Y197
45x52 45.52x52 E198
TM5
5x31 5.30x31 N203
5x32 5.31x32 T204
5x33 5.32x33 A205
5x36 5.35x36 R208
5x40 5.39x40 R212
TM6
6x58 6.58x58 D274
6x62 6.62x62 R278
TM7
7x27 7.28x27 R289
7x30 7.31x30 I292
7x31 7.32x31 D293
7x34 7.35x34 L296