PDB
8XX3
Resolution
3.4 Å
Released
Jan. 15, 2025
Receptor
CXCR2
Class
A
Species
Homo sapiens
Ligand
CXCL3
Function
Agonist
Reference
10.1016/J.MOLCEL.2025.01.024

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Ligand Amino Acid Generic Number Segment Interaction Type
CXCL3 L33 N-term hydrophobic
CXCL3 L33 N-term Van der Waals
CXCL3 L34 N-term Van der Waals
CXCL3 A36 N-term hydrophobic
CXCL3 A36 N-term Van der Waals
CXCL3 P38 N-term hydrophobic
CXCL3 P38 N-term Van der Waals
CXCL3 S43 N-term Van der Waals
CXCL3 S43 N-term polar (hydrogen bond)
CXCL3 K108 2.64x64 TM2 Van der Waals
CXCL3 V187 ECL2 hydrophobic
CXCL3 V187 ECL2 Van der Waals
CXCL3 S189 ECL2 polar (hydrogen bond)
CXCL3 S189 ECL2 Van der Waals
CXCL3 N191 ECL2 polar (hydrogen bond with backbone)
CXCL3 N191 ECL2 polar (hydrogen bond)
CXCL3 N191 ECL2 Van der Waals
CXCL3 V192 ECL2 hydrophobic
CXCL3 V192 ECL2 Van der Waals
CXCL3 S193 ECL2 polar (hydrogen bond)
CXCL3 S193 ECL2 Van der Waals
CXCL3 S193 ECL2 polar (hydrogen bond with backbone)
CXCL3 Y197 45.51x51 ECL2 hydrophobic
CXCL3 Y197 45.51x51 ECL2 Van der Waals
CXCL3 D199 ECL2 Van der Waals
CXCL3 N202 ECL2 Van der Waals
CXCL3 T204 5.31x32 TM5 Van der Waals
CXCL3 R208 5.35x36 TM5 polar (charge-assisted hydrogen bond)
CXCL3 R212 5.39x40 TM5 polar (charge-assisted hydrogen bond)
CXCL3 D274 6.58x58 TM6 polar (charge-assisted hydrogen bond)
CXCL3 R278 6.62x62 TM6 polar (charge-assisted hydrogen bond)
CXCL3 D293 7.32x31 TM7 polar (charge-assisted hydrogen bond)
CXCL3 L296 7.35x34 TM7 hydrophobic
CXCL3 L296 7.35x34 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R V G R ICL1ECL1 G W I F ECL1ICL2 A T R T L T Q K R Y ICL2ECL2 R T V Y S S N V S P A C Y E D M G N ECL2ICL3 H M G ICL3ECL3 V I Q E ECL3N-term M E D F N M E S D S F E D F W K G E D L S N Y S Y S S T L P P F L L D A A P C E P E S L N-termC-term G L I S K D S L P K D S R P S F V G S S S G H T S T T L C-term E I N K Y F V V I I Y A L V F L L S L L G N S L V M L V I L Y S S V T D V Y L L N L A L A D L L F A L T L P I W A A S K V N G T F L C K V V S L L K E V N F Y S G I L L L A C I S V D R Y L A I V H L V K F I C L S I W G L S L L L A L P V L L F R N T A N W R M L L R I L P Q S F G F I V P L L I M L F C Y G F T L R T L F K A Q K H R A M R V I F A V V L I F L L C W L P Y N L V L L A D T L M R T Q T C E R R N H I D R A L D A T E I L G I L H S C L N P L I Y A F I G Q K L L K H F R H G I L A I
Helix box plot — Download: PNG | SVG S N G L L S L L F V L A Y I I V V F Y K 1 L N L A L A D L L F A L T L P I W A A S 2 C A L L L I G S Y F N V E K L L S V V K 3 V K F I C L S I W G L S L L L A L P V 4 Y C F L M I L L P V I F G F S Q P L I R L 5 F A V V L I F L L C W L P Y N L V L L A 6 L P N L C S H L I G L I E T A D L A R 7

GPCRdb(A)
GPCRdb(A)
CXCR2
TM2
2x64 2.64x64 K108
ECL2
45x51 45.51x51 Y197
TM5
5x32 5.31x32 T204
5x36 5.35x36 R208
5x40 5.39x40 R212
TM6
6x58 6.58x58 D274
6x62 6.62x62 R278
TM7
7x31 7.32x31 D293
7x34 7.35x34 L296