PDB
8Y0H
Resolution
3.5 Å
Released
Feb. 26, 2025
Receptor
CXCR3
Class
A
Species
Homo sapiens
Ligand
CHEMBL2221034
Function
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL2221034 W109 2.60x60 TM2 hydrophobic
CHEMBL2221034 F131 3.32x32 TM3 hydrophobic
CHEMBL2221034 F135 3.36x36 TM3 aromatic (face-to-edge)
CHEMBL2221034 W268 6.48x48 TM6 aromatic (face-to-edge)
CHEMBL2221034 Y271 6.51x51 TM6 aromatic (face-to-face)
CHEMBL2221034 Y308 7.43x42 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 R T A L ICL1ECL1 Q W V F ECL1ICL2 A T Q L Y R R G P P ICL2ECL2 S A H H D E R L N A T H C Q Y N F ECL2ICL3 R G Q ICL3ECL3 A L A R ECL3N-term M V L E V S D H Q V L N D A E V A A L L E N F S S S Y D Y G E N E S D S C C T S P P C P N-termC-term G C P N Q R G L Q R Q P S S S R R D S S W S E T S E A S Y S G L C-term Q D F S L N F D R A F L P A L Y S L L F L L G L L G N G A V A A V L L S R S S T D T F L L H L A V A D T L L V L T L P L W A V D A A V G S G L C K V A G A L F N I N F Y A G A L L L A C I S F D R Y L N I V H A R V T L T C L A V W G L C L L F A L P D F I F L P Q V G R T A L R V L Q L V A G F L L P L L V M A Y C Y A H I L A V L L V S R R L R A M R L V V V V V V A F A L C W T P Y H L V V L V D I L M D L G N C G R E S R V D V A K S V T S G L G Y M H C C L N P L L Y A F V G V K M W M L F R E R L L L R
Helix box plot — Download: PNG | SVG G N G L L G L L F L L S Y L A P L F A R 1 L H L A V A D T L L V L T L P L W A V D 2 C A L L L A G A Y F N I N F L A G A V K 3 V T L T C L A V W G L C L L F A L P D 4 Y C Y A M V L L P L L F G A V L Q L V R L 5 V V V V V A F A L C W T P Y H L V V L V 6 L P N L C C H M Y G L G S T V S K A V 7

GPCRdb(A)
GPCRdb(A)
CXCR3
TM2
2x60 2.60x60 W109
TM3
3x32 3.32x32 F131
3x36 3.36x36 F135
TM6
6x48 6.48x48 W268
6x51 6.51x51 Y271
TM7
7x42 7.43x42 Y308