PDB
8Y6Y
Resolution
3.4 Å
Released
April 2, 2025
Receptor
FFA2
Class
A
Species
Homo sapiens
Ligand
Function
GLPG0974
Allosteric antagonist
Reference
—

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
GLPG0974 L61 2.56x56 TM2 hydrophobic
GLPG0974 L62 2.57x57 TM2 hydrophobic
GLPG0974 K65 2.60x60 TM2 aromatic (pi-cation)
GLPG0974 K65 2.60x60 TM2 hydrophobic
GLPG0974 E68 2.63x63 TM2 Van der Waals
GLPG0974 L77 23.52x52 ECL1 Van der Waals
GLPG0974 V81 3.24x24 TM3 Van der Waals
GLPG0974 C82 3.25x25 TM3 hydrophobic
GLPG0974 T85 3.28x28 TM3 hydrophobic
GLPG0974 S86 3.29x29 TM3 Van der Waals
GLPG0974 F89 3.32x32 TM3 hydrophobic
GLPG0974 T163 ECL2 hydrophobic
GLPG0974 C164 45.50x50 ECL2 hydrophobic
GLPG0974 E166 45.52x52 ECL2 Van der Waals
GLPG0974 Y344 6.51x51 TM6 Van der Waals
GLPG0974 R361 7.35x34 TM7 Van der Waals
GLPG0974 V365 7.39x38 TM7 hydrophobic

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 P Q P ICL1ECL1 N F R W Y L ECL1ICL2 P V Q Y K L S R ICL2ECL2 T E Q V R S G N E I T C Y E N F T D N ECL2ICL3 P L V ICL3ECL3 K S P W ECL3N-term M L N-termC-term R N Q G S S L L G R R G K D T A E G T N E D R G V G Q G E G M P S S D F T T E C-term P D W K S S L I L M A Y I I I F L T G L P A N L L A L R A F V G R I R Q A P V H I L L L S L T L A D L L L L L L L P F K I I E A A S P K V V C A L T S F G F Y S S I Y C S T W L L A G I S I E R Y L G V A F R P L Y G V I A A L V A W V M S F G H C T I V I I V Q Y L N T Q L D V V L P V R L E L C L V L F F I P M A V T I F C Y W R F V W I M L S Q G A Q R R R R A V G L A V V T L L N F L V C F G P Y N V S H L V G Y H Q R W R S I A V V F S S L N A S L D P L L F Y F S S S V F G R L V R R A G L Q V
Helix box plot — Download: PNG | SVG L N A P L G T L F I I I Y A M L I L S S 1 L S L T L A D L L L L L L L P F K I I E 2 G A L L W T S C Y I S S Y F G F S T L A 3 G V I A A L V A W V M S F G H C T I V I 4 Y C F I T V A M P I F F L V L C L E L R V 5 A V V T L L N F V L C F G P Y N V S H L V 6 L P D L S A N L S S F V V A I S R W 7

GPCRdb(A)
GPCRdb(A)
FFA2 receptor
TM2
2x56 2.56x56 L61
2x57 2.57x57 L62
2x60 2.60x60 K65
2x63 2.63x63 E68
ECL1
23x52 23.52x52 L77
TM3
3x24 3.24x24 V81
3x25 3.25x25 C82
3x28 3.28x28 T85
3x29 3.29x29 S86
3x32 3.32x32 F89
ECL2
45x50 45.50x50 C164
45x52 45.52x52 E166
TM6
6x51 6.51x51 Y238
TM7
7x34 7.35x34 R255
7x38 7.39x38 V259