PDB
8YFO
Resolution
2.7 Å
Released
Sept. 3, 2025
Receptor
PTH1
Class
B1
Species
Homo sapiens
Ligand
Ac-LA-PTH
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
Ac-LA-PTH V31 N-term polar (hydrogen bond with backbone)
Ac-LA-PTH V31 N-term Van der Waals
Ac-LA-PTH M32 N-term Van der Waals
Ac-LA-PTH T33 N-term Van der Waals
Ac-LA-PTH E35 N-term Van der Waals
Ac-LA-PTH E36 N-term Van der Waals
Ac-LA-PTH Y145 N-term Van der Waals
Ac-LA-PTH R181 1.33x33 TM1 polar (charge-assisted hydrogen bond)
Ac-LA-PTH F184 1.36x36 TM1 Van der Waals
Ac-LA-PTH F184 1.36x36 TM1 hydrophobic
Ac-LA-PTH Y195 1.47x47 TM1 Van der Waals
Ac-LA-PTH Y195 1.47x47 TM1 polar (hydrogen bond)
Ac-LA-PTH Y245 2.72x72 TM2 hydrophobic
Ac-LA-PTH Y245 2.72x72 TM2 Van der Waals
Ac-LA-PTH F288 3.36x36 TM3 hydrophobic
Ac-LA-PTH F288 3.36x36 TM3 Van der Waals
Ac-LA-PTH L292 3.40x40 TM3 hydrophobic
Ac-LA-PTH L292 3.40x40 TM3 Van der Waals
Ac-LA-PTH D353 45.52x52 ECL2 polar (charge-assisted hydrogen bond)
Ac-LA-PTH L354 ECL2 Van der Waals
Ac-LA-PTH L354 ECL2 hydrophobic
Ac-LA-PTH S355 ECL2 Van der Waals
Ac-LA-PTH K360 5.36x37 TM5 Van der Waals
Ac-LA-PTH Q364 5.40x40 TM5 Van der Waals
Ac-LA-PTH L368 5.44x44 TM5 hydrophobic
Ac-LA-PTH L368 5.44x44 TM5 Van der Waals
Ac-LA-PTH M425 6.57x57 TM6 Van der Waals
Ac-LA-PTH Y429 ECL3 hydrophobic
Ac-LA-PTH Y429 ECL3 Van der Waals
Ac-LA-PTH T430 ECL3 Van der Waals
Ac-LA-PTH T430 ECL3 polar (hydrogen bond with backbone)
Ac-LA-PTH W437 7.35x34 TM7 polar (hydrogen bond)
Ac-LA-PTH M441 7.39x38 TM7 hydrophobic
Ac-LA-PTH M441 7.39x38 TM7 Van der Waals
Ac-LA-PTH E444 7.42x41 TM7 Van der Waals
Ac-LA-PTH M445 7.43x42 TM7 polar (hydrogen bond)

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ICL1 R R L H ICL1ECL1 L D E A E R L T E E E L R A I A Q A P P P P A T A A A ECL1ICL2 A F F ICL2ECL2 N T G C W D L S S ECL2ICL3 R E T N A G R C ICL3ECL3 P Y T E V S ECL3N-term M G T A R I A P G L A L L L C C P V L S S A Y A L V D A D D V M T K E E Q I F L L H R A Q A Q C E K R L K E V L Q R P A S I M E S D K G W T S A S T S G K P R K D K A S G K L Y P E S E E D K E A P T G S R Y R G R P C L P E W D H I L C W P L G A P G E V V A V P C P D Y I Y D F N H K G H A Y R R C D R N G S W E L V P G H N R T W A N Y S E C V K N-termC-term S G S S S Y S Y G P M V S H T S V T N V G P R V G L G L P L S P R L L P T A T T N G H P Q L P G H A K P G T P A L E T L E T T P P A M A A P K D D G F L N G S C S G L D E E A S G P E R P P A L L Q E E W E T V M C-term F L T N E T R E R E V F D R L G M I Y T V G Y S V S L A S L T V A V L I L A Y F C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y S G A T G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L D T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T G T L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E I K K W T L K R K V Q A E S W S R A L D F A R
Helix box plot — Download: PNG | SVG T L S A L S V S Y G V T Y I M G L R D F 1 M H L F L S F M L R A V S I F V K D A V 2 V L I W Y Y N T A L F Y L F F T V A V R 3 Y L W G F T V G F W G L P A V F V A V W V 4 F L I F N L V I S A L I P V Q I I W K K N 5 L V L M P L F G V H Y I V F M A T 6 I A V F F G Q F S N F L M E Y H M Q V 7

GPCRdb(A)
GPCRdb(B)
PTH1 receptor
TM1
1x29 1.33x33 R181
1x32 1.36x36 F184
1x43 1.47x47 Y195
TM2
2x65 2.72x72 Y245
TM3
3x32 3.36x36 F288
3x36 3.40x40 L292
ECL2
45x52 45.52x52 D353
TM5
5x41 5.36x37 K360
5x44 5.40x40 Q364
5x48 5.44x44 L368
TM6
6x52 6.57x57 M425
TM7
7x30 7.35x34 W437
7x34 7.39x38 M441
7x37 7.42x41 E444
7x38 7.43x42 M445