PDB
8YG4
Resolution
2.6 Å
Released
Sept. 3, 2025
Receptor
PTH1
Class
B1
Species
Homo sapiens
Ligand
LA-PTH-R1
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
LA-PTH-R1 V31 N-term polar (hydrogen bond with backbone)
LA-PTH-R1 V31 N-term Van der Waals
LA-PTH-R1 M32 N-term Van der Waals
LA-PTH-R1 T33 N-term Van der Waals
LA-PTH-R1 E36 N-term Van der Waals
LA-PTH-R1 F39 N-term hydrophobic
LA-PTH-R1 F39 N-term Van der Waals
LA-PTH-R1 E180 1.32x32 TM1 polar (charge-assisted hydrogen bond)
LA-PTH-R1 R181 1.33x33 TM1 Van der Waals
LA-PTH-R1 F184 1.36x36 TM1 aromatic (edge-to-face)
LA-PTH-R1 F184 1.36x36 TM1 Van der Waals
LA-PTH-R1 Y245 2.72x72 TM2 hydrophobic
LA-PTH-R1 Y245 2.72x72 TM2 Van der Waals
LA-PTH-R1 V285 3.33x33 TM3 Van der Waals
LA-PTH-R1 F288 3.36x36 TM3 hydrophobic
LA-PTH-R1 F288 3.36x36 TM3 Van der Waals
LA-PTH-R1 L289 3.37x37 TM3 Van der Waals
LA-PTH-R1 L289 3.37x37 TM3 hydrophobic
LA-PTH-R1 L292 3.40x40 TM3 Van der Waals
LA-PTH-R1 L292 3.40x40 TM3 hydrophobic
LA-PTH-R1 D353 45.52x52 ECL2 Van der Waals
LA-PTH-R1 D353 45.52x52 ECL2 polar (hydrogen bond with backbone)
LA-PTH-R1 L354 ECL2 Van der Waals
LA-PTH-R1 L354 ECL2 hydrophobic
LA-PTH-R1 S355 ECL2 Van der Waals
LA-PTH-R1 K360 5.36x37 TM5 Van der Waals
LA-PTH-R1 W361 5.37x38 TM5 Van der Waals
LA-PTH-R1 Q364 5.40x40 TM5 polar (hydrogen bond)
LA-PTH-R1 L368 5.44x44 TM5 hydrophobic
LA-PTH-R1 L368 5.44x44 TM5 Van der Waals
LA-PTH-R1 M425 ECL3 polar (hydrogen bond with backbone)
LA-PTH-R1 M425 ECL3 Van der Waals
LA-PTH-R1 T427 ECL3 Van der Waals
LA-PTH-R1 Y429 ECL3 Van der Waals
LA-PTH-R1 Y429 ECL3 hydrophobic
LA-PTH-R1 T430 ECL3 Van der Waals
LA-PTH-R1 M441 7.39x38 TM7 hydrophobic
LA-PTH-R1 M441 7.39x38 TM7 Van der Waals
LA-PTH-R1 E444 7.42x41 TM7 Van der Waals
LA-PTH-R1 M445 7.43x42 TM7 polar (hydrogen bond)
LA-PTH-R1 N448 7.46x45 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R R L H ICL1ECL1 L D E A E R L T E E E L R A I A Q A P P P P A T A A A ECL1ICL2 A F F ICL2ECL2 N T G C W D L S S ECL2ICL3 R E T N A G R C ICL3ECL3 P Y T E V S ECL3N-term M G T A R I A P G L A L L L C C P V L S S A Y A L V D A D D V M T K E E Q I F L L H R A Q A Q C E K R L K E V L Q R P A S I M E S D K G W T S A S T S G K P R K D K A S G K L Y P E S E E D K E A P T G S R Y R G R P C L P E W D H I L C W P L G A P G E V V A V P C P D Y I Y D F N H K G H A Y R R C D R N G S W E L V P G H N R T W A N Y S E C V K N-termC-term S G S S S Y S Y G P M V S H T S V T N V G P R V G L G L P L S P R L L P T A T T N G H P Q L P G H A K P G T P A L E T L E T T P P A M A A P K D D G F L N G S C S G L D E E A S G P E R P P A L L Q E E W E T V M C-term F L T N E T R E R E V F D R L G M I Y T V G Y S V S L A S L T V A V L I L A Y F C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y S G A T G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L D T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T G T L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E I K K W T L K R K V Q A E S W S R A L D F A R
Helix box plot — Download: PNG | SVG T L S A L S V S Y G V T Y I M G L R D F 1 M H L F L S F M L R A V S I F V K D A V 2 V L I W Y Y N T A L F Y L F F T V A V R 3 Y L W G F T V G F W G L P A V F V A V W V 4 F L I F N L V I S A L I P V Q I I W K K N 5 L V L M P L F G V H Y I V F M A T 6 I A V F F G Q F S N F L M E Y H M Q V 7

GPCRdb(A)
GPCRdb(B)
PTH1 receptor
TM1
1x28 1.32x32 E180
1x29 1.33x33 R181
1x32 1.36x36 F184
TM2
2x65 2.72x72 Y245
TM3
3x29 3.33x33 V285
3x32 3.36x36 F288
3x33 3.37x37 L289
3x36 3.40x40 L292
ECL2
45x52 45.52x52 D353
TM5
5x41 5.36x37 K360
5x42 5.37x38 W361
5x44 5.40x40 Q364
5x48 5.44x44 L368
TM7
7x34 7.39x38 M441
7x37 7.42x41 E444
7x38 7.43x42 M445
7x41 7.46x45 N448