PDB
8YH5
Resolution
3.7 Å
Released
Nov. 6, 2024
Receptor
A3
Class
A
Species
Ovis aries
Ligand
Function
Riboprine
Agonist
Reference
10.1038/S41467-024-53473-1

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Ligand Amino Acid Generic Number Segment Interaction Type
Riboprine A69 2.61x60 TM2 Van der Waals
Riboprine I72 2.64x63 TM2 Van der Waals
Riboprine M90 3.32x32 TM3 Van der Waals
Riboprine L91 3.33x33 TM3 Van der Waals
Riboprine F167 45.52x52 ECL2 aromatic (face-to-face)
Riboprine F167 45.52x52 ECL2 hydrophobic
Riboprine M173 ECL2 hydrophobic
Riboprine M176 ECL2 Van der Waals
Riboprine L245 6.51x51 TM6 Van der Waals
Riboprine N249 6.55x55 TM6 hydrophobic
Riboprine L252 6.58x58 TM6 hydrophobic
Riboprine L263 7.35x34 TM7 hydrophobic
Riboprine I267 7.39x38 TM7 Van der Waals
Riboprine H271 7.43x42 TM7 polar (hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 P S L Q ICL1ECL1 V T I ECL1ICL2 T V R Y R R V T ICL2ECL2 W N M K L S S A D E N L T F L P C R F R S V M R M D Y M V Y F ECL2ECL3 D G Q V ECL3N-term M P V N S T A V N-termC-term Q P S K S M D P S T E Q T S E C-term S W T S V T Y I T V E I L I G L C A I V G N V L V I W V V K L N T T T F Y F I V S L A L A D I A V G V L V M P L A I V I S L G H F Y S C L F M T C L M L I F T H A S I M S L L A I A V D R Y L R V K L T Q R R I W L A L G L C W L V S F L V G L T P M F G S F F L W I L V P L V V M C A I Y F D I F Y I I R N R L S Q S F S G S R E T G A F Y G R E F K T A K S L L L V L F L F A L C W L P L S I I N C I L Y F P Q T V L Y L G I L L S H A N S M M N P I V Y A Y K I K K F L L I V M C K E T Y L K A C
Helix box plot — Download: PNG | SVG V N G V I A C L G I L I E V T I Y T V S 1 V S L A L A D I A V G L V V M P L A I V I 2 A L L S M I S A H T F I L M L C T M F L 3 I W L A L G L C W L V S F L V G L T P M 4 Y I A C M V V L P V L I W L F F S 5 L L V L F L F A L C W L P L S I I N C I 6 I P N M M S N A H S L L I G L Y L V T 7

GPCRdb(A)
GPCRdb(A)
A3 receptor
TM2
2x60 2.61x60 A69
2x63 2.64x63 I72
TM3
3x32 3.32x32 M90
3x33 3.33x33 L91
ECL2
45x52 45.52x52 F167
TM6
6x51 6.51x51 L245
6x55 6.55x55 N249
6x58 6.58x58 L252
TM7
7x34 7.35x34 L263
7x38 7.39x38 I267
7x42 7.43x42 H271