PDB
8YIC
Resolution
3.5 Å
Released
Dec. 11, 2024
Receptor
S1P1
Class
A
Species
Homo sapiens
Ligand
SAR247799
Function
Agonist
Reference
—

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
SAR247799 R120 3.28x28 TM3 polar (charge-assisted hydrogen bond)
SAR247799 E121 3.29x29 TM3 Van der Waals
SAR247799 M124 3.32x32 TM3 hydrophobic
SAR247799 M124 3.32x32 TM3 Van der Waals
SAR247799 F125 3.33x33 TM3 Van der Waals
SAR247799 F125 3.33x33 TM3 aromatic (face-to-face)
SAR247799 L128 3.36x36 TM3 hydrophobic
SAR247799 L128 3.36x36 TM3 Van der Waals
SAR247799 S129 3.37x37 TM3 Van der Waals
SAR247799 L195 ECL2 hydrophobic
SAR247799 L195 ECL2 Van der Waals
SAR247799 L272 6.51x51 TM6 hydrophobic
SAR247799 L297 7.39x38 TM7 hydrophobic
SAR247799 L297 7.39x38 TM7 Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 K K F H ICL1ECL1 G A T T Y K L ECL1ICL2 M K L H N G S ICL2ECL2 W N C I S A L S S C S T V L P L Y ECL2ICL3 F R K N I S K A ICL3ECL3 K V K T C ECL3N-term M G P T S V P L V K A H R S S V S D Y V N Y D I I V R H Y N Y T G K L N I S A D K N-termC-term C C K C P S G D S A G K F K R P I I A G M E F S R S K S D N S S H P Q K D E G D N P E T I M S S G N V N S S S C-term E N S I K L T S V V F I L I C C F I I L E N I F V L L T I W K T R P M Y Y F I G N L A L S D L L A G V A Y T A N L L L S T P A Q W F L R E G S M F V A L S A S V F S L L A I A I E R Y I T M L K N N F R L F L L I S A C W V I S L I L G G L P I M G H K H Y I L F C T T V F T L L L L S I V I L Y C R I Y S L V R T R S R R L T S R S S E K S L A L L K T V I I V L S V F I A C W A P L F I L L L L D V G C D I L F R A E Y F L V L A V L N S G T N P I I Y T L T N K E F I R M R R A I M S
Helix box plot — Download: PNG | SVG I N E L I I F C C I L I F V V S T L K I 1 G N L A L S D L L A G V A Y T A N L L L 2 A L L S F V S A S L A V F M S G E R L F 3 L F L L I S A C W V I S L I L G G L P I 4 Y L I V I S L L L L T F V T T C F L I Y 5 I I V L S V F I A C W A P L F I L L L L 6 I P N T G S N L V A L V L F Y E A R F 7

GPCRdb(A)
GPCRdb(A)
S1P1 receptor
TM3
3x28 3.28x28 R120
3x29 3.29x29 E121
3x32 3.32x32 M124
3x33 3.33x33 F125
3x36 3.36x36 L128
3x37 3.37x37 S129
TM6
6x51 6.51x51 L272
TM7
7x38 7.39x38 L297