PDB
8YKY
Resolution
3.0 Å
Released
July 10, 2024
Receptor
TAS2R14
Class
T2
Species
Homo sapiens
Ligands
Cholesterol
compound 28.1 [PMID: 36847646]
Function
Agonist
Allosteric agonist
Reference
—
Cholesterol compound 28.1 [PMID: 36847646]

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Ligand Amino Acid Generic Number Segment Interaction Type
Cholesterol F76 ECL1 hydrophobic
Cholesterol F82 3.25x25 TM3 hydrophobic
Cholesterol L85 3.28x28 TM3 hydrophobic
Cholesterol W89 3.32x32 TM3 hydrophobic
compound 28.1 [PMID: 36847646] Y107 3.50x50 TM3 hydrophobic
Cholesterol V180 5.40x41 TM5 hydrophobic
Cholesterol I187 5.47x47 TM5 hydrophobic
compound 28.1 [PMID: 36847646] F198 5.58x58 TM5 aromatic (edge-to-face)
compound 28.1 [PMID: 36847646] L201 5.61x61 TM5 hydrophobic
compound 28.1 [PMID: 36847646] V233 6.38x38 TM6 hydrophobic
compound 28.1 [PMID: 36847646] F237 6.42x42 TM6 aromatic (edge-to-face)
Cholesterol I262 7.35x34 TM7 hydrophobic
Cholesterol M268 7.41x40 TM7 hydrophobic
compound 28.1 [PMID: 36847646] H276 7.49x49 TM7 polar (hydrogen bond)
compound 28.1 [PMID: 36847646] H276 7.49x49 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R K I ICL1ECL1 P A L F A ECL1ICL2 N F S N S I F L Y L K W ICL2ECL2 A S I N G Y R R N K T C S S D S S N F T R F S S L ECL2ICL3 K I S G D A S T K A ICL3ECL3 E E ECL3C-term G E P S G H K E F R E S S C-term M G G V I K S I F T F V L I V E F I I G N L G N S F I A L V N C I D W V K G S S V D R I L T A L A I S R I S L V W L I F G S W C V S V F F T E K M F R M L T N I W T V I N H F S V W L A T G L G T F Y F L K I A R V K K V V L V L L L V T S V F L F L N I A L I N I H I N I V L T S T V F I F I P F T L S L A M F L L L I F S M W K H R K K M Q H T V H R G V K S V I T F F L L Y A I F S L S F F I S V W T S E R L N L I I L S Q V M G M A Y P S C H S C V L I L G N K K S L S L R Y L R Q A V L L W M F K D
Helix box plot — Download: PNG | SVG S N G L N G I I F E V I L V F T F I S K 1 T A L A I S R I S L V W L I F G S W C V 2 G T A L W V S F H N I V T W I N T L M R 3 V L V L L L V T S V F L F L N I A L I N 4 F M A L S L T F P I F I F V T S T L V I 5 V I T F F L L Y A I F S L S F F I S V W 6 C S H C S P Y A M G M V Q S L I I L N 7

GPCRdb(A)
GPCRdb(A)
TAS2R14
TM3
3x25 3.25x25 F82
3x28 3.28x28 L85
3x32 3.32x32 W89
3x50 3.50x50 Y107
TM5
5x41 5.40x41 V180
5x47 5.47x47 I187
5x58 5.58x58 F198
5x61 5.61x61 L201
TM6
6x38 6.38x38 V233
6x42 6.42x42 F237
TM7
7x34 7.35x34 I262
7x40 7.41x40 M268
7x49 7.49x49 H276