PDB
8YN6
Resolution
2.8 Å
Released
Oct. 9, 2024
Receptor
H3
Class
A
Species
Homo sapiens
Ligand
Function
imetit
Agonist
Reference
10.1038/S41467-024-52585-Y

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
imetit D114 3.32x32 TM3 polar (hydrogen bond)
imetit D114 3.32x32 TM3 polar (charge-charge)
imetit Y115 3.33x33 TM3 hydrophobic
imetit C118 3.36x36 TM3 hydrophobic
imetit E206 5.46x461 TM5 polar (hydrogen bond)
imetit E206 5.46x461 TM5 polar (charge-charge)
imetit W371 6.48x48 TM6 Van der Waals
imetit Y374 6.51x51 TM6 aromatic (pi-cation)
imetit Y374 6.51x51 TM6 aromatic (edge-to-face)
imetit F398 7.39x38 TM7 aromatic (face-to-face)
imetit F398 7.39x38 TM7 aromatic (pi-cation)
imetit F398 7.39x38 TM7 polar (hydrogen bond with backbone)
imetit L401 7.42x41 TM7 hydrophobic
imetit W402 7.43x42 TM7 aromatic (edge-to-face)

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 S S L R ICL1ECL1 G R W T F ECL1ICL2 A V S Y R A Q Q G ICL2ECL2 W E Y L S G G S S I P E G H C Y A E F F Y ECL2ICL3 A R E A A G P E P P P E A Q P S P P P P P G C W G C W Q K G H G E A M P L H R Y G V G E A A V G A E A G E A T L G G G G G G G S V A S P T S S S G S S S R G T E R P R S L K R G S K P S A S S A S L E K R M K M V S Q S F T Q ICL3ECL3 H G H C V ECL3N-term M E R A P P D G P L N A S G A L A G E A A A A G G A R G F S A A W T A N-termC-term P Q K L K I Q P H S S L E H C W K C-term V L A A L M A L L I V A T V L G N A L V M L A F V A D T Q N N F F L L N L A I S D F L V G A F C I P L Y V P Y V L T G R G L C K L W L V V D Y L L C T S S A F N I V L I S Y D R F L S V T R D T R R A V R K M L L V W V L A F L L Y G P A I L S N W Y F L I T A S T L E F F T P F L S V T F F N L S I Y L N I Q R R T R L R L D G R F R L S R D R K V A K S L A V I V S I F G L C W A P Y T L L M I I R A A C P D Y W Y E T S F W L L W A N S A V N P V L Y P L C H H S F T K F R R A L L C
Helix box plot — Download: PNG | SVG A N G L V T A V I L L A M L A A L V 1 L N L A I S D F L V G F A C I P L Y V P Y 2 L V I N F A S S T C L L Y D V V L W L K 3 A V R K M L L V W V L A F L L Y G P A 4 N F F T V S L F P T F F E L T S A T I L F 5 A V I V S I F G L C W A P Y T L L M I I 6 V P N V A S N A W L L W F S T E Y W Y 7

GPCRdb(A)
GPCRdb(A)
H3 receptor
TM3
3x32 3.32x32 D114
3x33 3.33x33 Y115
3x36 3.36x36 C118
TM5
5x461 5.46x461 E206
TM6
6x48 6.48x48 W371
6x51 6.51x51 Y374
TM7
7x38 7.39x38 F398
7x41 7.42x41 L401
7x42 7.43x42 W402