Structure information

H3 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8YN6

SPECIES

Homo sapiens

RESOLUTION

2.770

PREFERRED CHAIN

R

REFERENCE

10.1038/S41467-024-52585-Y

PUBLICATION DATE

Oct. 9, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
imetit D114 3.32x32 TM3 polar (charge-assisted hydrogen bond)
imetit Y115 3.33x33 TM3 Van der Waals
imetit C118 3.36x36 TM3 Van der Waals
imetit E206 5.46x461 TM5 polar (charge-assisted hydrogen bond)
imetit Y374 6.51x51 TM6 aromatic (face-to-edge)
imetit Y374 6.51x51 TM6 Van der Waals
imetit F398 7.39x38 TM7 polar (hydrogen bond with backbone)
imetit F398 7.39x38 TM7 aromatic (face-to-face)
imetit F398 7.39x38 TM7 Van der Waals
imetit L401 7.42x41 TM7 hydrophobic
imetit L401 7.42x41 TM7 Van der Waals
imetit W402 7.43x42 TM7 aromatic (face-to-edge)
imetit W402 7.43x42 TM7 polar (hydrogen bond)

Ligands

imetit

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Residue Diagrams

A N G L V T A V I L L A M L A A L V 1 L N L A I S D F L V G F A C I P L Y V P Y 2 L V I N F A S S T C L L Y D V V L W L K 3 A V R K M L L V W V L A F L L Y G P A 4 N F F T V S L F P T F F E L T S A T I L F 5 A V I V S I F G L C W A P Y T L L M I I 6 V P N V A S N A W L L W F S T E Y W Y 7
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ICL1 S S L R ICL1ECL1 G R W T F ECL1ICL2 A V S Y R A Q Q G ICL2ECL2 W E Y L S G G S S I P E G H C Y A E F F Y ECL2ICL3 A R E A A G P E P P P E A Q P S P P P P P G C W G C W Q K G H G E A M P L H R Y G V G E A A V G A E A G E A T L G G G G G G G S V A S P T S S S G S S S R G T E R P R S L K R G S K P S A S S A S L E K R M K M V S Q S F T Q ICL3ECL3 H G H C V ECL3N-term M E R A P P D G P L N A S G A L A G E A A A A G G A R G F S A A W T A N-termC-term P Q K L K I Q P H S S L E H C W K C-term V L A A L M A L L I V A T V L G N A L V M L A F V A D T Q N N F F L L N L A I S D F L V G A F C I P L Y V P Y V L T G R G L C K L W L V V D Y L L C T S S A F N I V L I S Y D R F L S V T R D T R R A V R K M L L V W V L A F L L Y G P A I L S N W Y F L I T A S T L E F F T P F L S V T F F N L S I Y L N I Q R R T R L R L D G R F R L S R D R K V A K S L A V I V S I F G L C W A P Y T L L M I I R A A C P D Y W Y E T S F W L L W A N S A V N P V L Y P L C H H S F T K F R R A L L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
H3 receptor
TM3
3x32 3.32x32 D114
3x33 3.33x33 Y115
3x36 3.36x36 C118
TM5
5x461 5.46x461 E206
TM6
6x51 6.51x51 Y374
TM7
7x38 7.39x38 F398
7x41 7.42x41 L401
7x42 7.43x42 W402