PDB
8YN7
Resolution
2.8 Å
Released
Oct. 16, 2024
Receptor
H3
Class
A
Species
Homo sapiens
Ligand
immethridine
Function
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
immethridine D114 3.32x32 TM3 polar (charge-assisted hydrogen bond)
immethridine Y115 3.33x33 TM3 aromatic (face-to-face)
immethridine Y115 3.33x33 TM3 Van der Waals
immethridine C118 3.36x36 TM3 Van der Waals
immethridine E206 5.46x461 TM5 polar (charge-assisted hydrogen bond)
immethridine Y374 6.51x51 TM6 aromatic (face-to-edge)
immethridine Y374 6.51x51 TM6 Van der Waals
immethridine F398 7.39x38 TM7 Van der Waals
immethridine F398 7.39x38 TM7 aromatic (face-to-face)
immethridine F398 7.39x38 TM7 polar (hydrogen bond with backbone)
immethridine L401 7.42x41 TM7 Van der Waals
immethridine L401 7.42x41 TM7 hydrophobic
immethridine W402 7.43x42 TM7 Van der Waals
immethridine W402 7.43x42 TM7 polar (hydrogen bond)
immethridine W402 7.43x42 TM7 aromatic (face-to-edge)

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ICL1 S S L R ICL1ECL1 G R W T F ECL1ICL2 A V S Y R A Q Q G ICL2ECL2 W E Y L S G G S S I P E G H C Y A E F F Y ECL2ICL3 A R E A A G P E P P P E A Q P S P P P P P G C W G C W Q K G H G E A M P L H R Y G V G E A A V G A E A G E A T L G G G G G G G S V A S P T S S S G S S S R G T E R P R S L K R G S K P S A S S A S L E K R M K M V S Q S F T Q ICL3ECL3 H G H C V ECL3N-term M E R A P P D G P L N A S G A L A G E A A A A G G A R G F S A A W T A N-termC-term P Q K L K I Q P H S S L E H C W K C-term V L A A L M A L L I V A T V L G N A L V M L A F V A D T Q N N F F L L N L A I S D F L V G A F C I P L Y V P Y V L T G R G L C K L W L V V D Y L L C T S S A F N I V L I S Y D R F L S V T R D T R R A V R K M L L V W V L A F L L Y G P A I L S N W Y F L I T A S T L E F F T P F L S V T F F N L S I Y L N I Q R R T R L R L D G R F R L S R D R K V A K S L A V I V S I F G L C W A P Y T L L M I I R A A C P D Y W Y E T S F W L L W A N S A V N P V L Y P L C H H S F T K F R R A L L C
Helix box plot — Download: PNG | SVG A N G L V T A V I L L A M L A A L V 1 L N L A I S D F L V G F A C I P L Y V P Y 2 L V I N F A S S T C L L Y D V V L W L K 3 A V R K M L L V W V L A F L L Y G P A 4 N F F T V S L F P T F F E L T S A T I L F 5 A V I V S I F G L C W A P Y T L L M I I 6 V P N V A S N A W L L W F S T E Y W Y 7

GPCRdb(A)
GPCRdb(A)
H3 receptor
TM3
3x32 3.32x32 D114
3x33 3.33x33 Y115
3x36 3.36x36 C118
TM5
5x461 5.46x461 E206
TM6
6x51 6.51x51 Y374
TM7
7x38 7.39x38 F398
7x41 7.42x41 L401
7x42 7.43x42 W402