PDB
8YN9
Resolution
2.3 Å
Released
Oct. 9, 2024
Receptor
H4
Class
A
Species
Homo sapiens
Ligand
histamine
Function
Agonist
Reference
10.1038/S41467-024-52585-Y

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Ligand Amino Acid Generic Number Segment Interaction Type
histamine D94 3.32x32 TM3 polar (charge-assisted hydrogen bond)
histamine Y95 3.33x33 TM3 hydrophobic
histamine Y95 3.33x33 TM3 Van der Waals
histamine C98 3.36x36 TM3 Van der Waals
histamine Y319 6.51x51 TM6 aromatic (face-to-edge)
histamine Y319 6.51x51 TM6 Van der Waals
histamine F344 7.39x38 TM7 aromatic (face-to-face)
histamine F344 7.39x38 TM7 polar (hydrogen bond with backbone)
histamine F344 7.39x38 TM7 Van der Waals
histamine Q347 7.42x41 TM7 polar (hydrogen bond)
histamine W348 7.43x42 TM7 Van der Waals
histamine W348 7.43x42 TM7 polar (hydrogen bond)
histamine W348 7.43x42 TM7 aromatic (face-to-edge)

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ICL1 K N L R ICL1ECL1 F E W D F ECL1ICL2 A V S Y R T Q H T ICL2ECL2 D E G S E C E P G F F S ECL2ICL3 H P G L T A V S S N I C G H S F R G R L S S R R S L S A S T E V P A S F H S E R Q R R K S S L M F S S R T K M N S N T I A S K M G S F S Q S D S V A L H Q R E ICL3ECL3 S S A T G P K ECL3N-term M P D T N S T I N L N-termC-term K K Q P L P S Q H S R S V S S C-term S L S T R V T L A F F M S L V A F A I M L G N A L V I L A F V V D H R S S Y F F L N L A I S D F F V G V I S I P L Y I P H T L G K E I C V F W L T T D Y L L C T A S V Y N I V L I S Y D R Y L S V S N G V L K I V T L M V A V W V L A F L V N G P M I L V S E S W K E W Y I L A I T S F L E F V I P V I L V A Y F N M N I Y W S L W K R D H L S R C Q S H V E L L R A R R L A K S L A I L L G V F A V C W A P Y S L F T I V L S F Y S V W Y R I A F W L Q W F N S F V N P L L Y P L C H K R F L K F Q K A I F C I
Helix box plot — Download: PNG | SVG A N G L M I A F A V L S M F F A L T V R 1 L N L A I S D F F V G I V S I P L Y I P H 2 L V I N Y V S A T C L L Y D T T L W F V 3 I V T L M V A V W V L A F L V N G P M 4 N F Y A V L I V P I V F E L F S T I A L I 5 A I L L G V F A V C W A P Y S L F T I V 6 L P N V F S N F W Q L W F A I R Y W V 7

GPCRdb(A)
GPCRdb(A)
H4 receptor
TM3
3x32 3.32x32 D94
3x33 3.33x33 Y95
3x36 3.36x36 C98
TM6
6x51 6.51x51 Y319
TM7
7x38 7.39x38 F344
7x41 7.42x41 Q347
7x42 7.43x42 W348