PDB
8YYX
Resolution
2.8 Å
Released
April 9, 2025
Receptor
oxoglutarate
Class
A
Species
Homo sapiens
Ligand
Function
LTE4
Allosteric agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
LTE4 L122 3.41x41 TM3 hydrophobic
LTE4 C133 3.52x52 TM3 Van der Waals
LTE4 C141 ICL2 polar (hydrogen bond)
LTE4 I144 ICL2 Van der Waals
LTE4 R148 4.40x40 TM4 polar (charge-charge)
LTE4 R148 4.40x40 TM4 polar (hydrogen bond)
LTE4 C149 4.41x41 TM4 polar (hydrogen bond)
LTE4 V152 4.44x44 TM4 hydrophobic
LTE4 I160 4.52x52 TM4 hydrophobic
LTE4 T205 5.45x46 TM5 hydrophobic
LTE4 L209 5.49x49 TM5 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 M R P W ICL1ECL1 G E N W I F ECL1ICL2 P M S C F S I H ICL2ECL2 T S T N R T N R S A C L D L T S S D E ECL2ICL3 G L Q T ICL3ECL3 R L L S I ECL3N-term M N E P L D Y L A N A S D F P D Y A A A F G N C T D E N I P N-termC-term C K V S G N L E Q A K K I S Y S N N P C-term L K M H Y L P V I Y G I I F L V G F P G N A V V I S T Y I F K K S S T I I M L N L A C T D L L Y L T S L P F L I H Y Y A S G D F M C K F I R F S F H F N L Y S S I L F L T C F S I F R Y C V I I H K T R C A V V A C A V V W I I S L V A V I P M T F L I L N T I K W Y N L I L T A T T F C L P L V I V T L C Y T T I I H T L T H D S C L K Q K A R R L T I L L L L A F Y V C F L P F H I L R V I R I E S S C S I E N Q I H E A Y I V S R P L A A L N T F G N L L L Y V V V S D N V C S F Q Q A T V R
Helix box plot — Download: PNG | SVG A N G P F G V L F I I G Y I V P L Y H M 1 L N L A C T D L L Y L T S L P F L I H Y 2 C T L F L I S S Y L N F H F S F R I F K 3 A V V A C A V V W I I S L V A V I P M 4 Y C L T V I V L P L C F T T A T L I L N Y 5 I L L L L A F Y V C F L P F H I L R V I 6 L L N G F T N L A A L P R S V I Y A E 7

GPCRdb(A)
GPCRdb(A)
oxoglutarate receptor
TM3
3x41 3.41x41 L122
3x52 3.52x52 C133
TM4
4x40 4.40x40 R148
4x41 4.41x41 C149
4x44 4.44x44 V152
4x52 4.52x52 I160
TM5
5x46 5.45x46 T205
5x49 5.49x49 L209