PDB
8Z87
Resolution
2.7 Å
Released
Nov. 5, 2025
Receptor
HCA1
Class
A
Species
Homo sapiens
Ligand
Function
CHEMBL2146910
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL2146910 R71 2.60x60 TM2 aromatic (pi-cation)
CHEMBL2146910 Y75 2.64x64 TM2 Van der Waals
CHEMBL2146910 L92 3.29x29 TM3 Van der Waals
CHEMBL2146910 L95 3.32x32 TM3 Van der Waals
CHEMBL2146910 R99 3.36x36 TM3 polar (charge-charge)
CHEMBL2146910 R99 3.36x36 TM3 polar (hydrogen bond)
CHEMBL2146910 E166 45.51x51 ECL2 Van der Waals
CHEMBL2146910 S167 45.52x52 ECL2 polar (hydrogen bond with backbone)
CHEMBL2146910 F168 ECL2 hydrophobic
CHEMBL2146910 F168 ECL2 aromatic (edge-to-face)
CHEMBL2146910 H261 7.36x35 TM7 hydrophobic
CHEMBL2146910 H261 7.36x35 TM7 aromatic (edge-to-face)
CHEMBL2146910 L264 7.39x38 TM7 hydrophobic
CHEMBL2146910 Y268 7.43x42 TM7 polar (hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 M K T W ICL1ECL1 R R H W A F ECL1ICL2 P H H A V N T I ICL2ECL2 H L C V Q E T A V S C E S F I ECL2ICL3 R Q Q L A ICL3ECL3 V P S S A C ECL3N-term M Y N G S C C R I E G D N-termC-term C S L K P K Q P G H S K T Q R P E E M P I S N L G R R S C I S V A N S F Q S Q S D G Q W D P H I V E W H C-term T I S Q V M P P L L I V A F V L G A L G N G V A L C G F C F H K P S T V Y L F N L A V A D F L L M I C L P F R T D Y Y L R G D I P C R V G L F T L A M N R A G S I V F L T V V A A D R Y F K V V H S T R V A A G I V C T L W A L V I L G T V Y L L L E N M E S A N G W H D I M F Q L E F F M P L G I I L F C S F K I V W S L R R R Q A R M K K A T R F I M V V A I V F I T C Y L P S V S A R L Y F L W T D P S V H G A L H I T L S F T Y M N S M L D P L V Y Y F S S P S Y N K F P K F L K I
Helix box plot — Download: PNG | SVG G N G L A G L V F A V I L L P P M V Q S 1 F N L A V A D F L L M I C L P F R T D Y 2 V T L F V I S G A R N M A L T F L G V R 3 A A G I V C T L W A L V I L G T V Y L L 4 S C F L I I G L P M F F E L Q F M I D H W 5 M V V A I V F I T C Y L P S V S A R L Y 6 L P D L M S N M Y T F S L T I H L A G 7

GPCRdb(A)
GPCRdb(A)
HCA1 receptor
TM2
2x60 2.60x60 R71
2x64 2.64x64 Y75
TM3
3x29 3.29x29 L92
3x32 3.32x32 L95
3x36 3.36x36 R99
ECL2
45x51 45.51x51 E166
45x52 45.52x52 S167
TM7
7x35 7.36x35 H261
7x38 7.39x38 L264
7x42 7.43x42 Y268