PDB
8ZBE
Resolution
3.2 Å
Released
July 10, 2024
Receptor
SST5
Class
A
Species
Homo sapiens
Ligand
Function
octreotide
Agonist
Reference
10.1038/S41401-024-01314-8

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Ligand Amino Acid Generic Number Segment Interaction Type
octreotide Q99 2.63x63 TM2 Van der Waals
octreotide G120 3.33x33 TM3 Van der Waals
octreotide Q123 3.36x36 TM3 Van der Waals
octreotide F124 3.37x37 TM3 hydrophobic
octreotide N187 45.51x51 ECL2 hydrophobic
octreotide S189 ECL2 hydrophobic
octreotide W190 ECL2 Van der Waals
octreotide G198 5.35x36 TM5 Van der Waals
octreotide F201 5.38x39 TM5 aromatic (edge-to-face)
octreotide I202 5.39x40 TM5 hydrophobic
octreotide T205 5.42x43 TM5 hydrophobic
octreotide F264 6.51x51 TM6 hydrophobic
octreotide F264 6.51x51 TM6 aromatic (edge-to-face)
octreotide N268 6.55x55 TM6 Van der Waals
octreotide N271 6.58x58 TM6 Van der Waals
octreotide Y286 7.35x34 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 A K M K ICL1ECL1 S F W P F ECL1ICL2 P L S S A R W R ICL2ECL2 D V Q E G G T C N A S W P E ECL2ICL3 G C V R ICL3ECL3 A L P Q E P A ECL3N-term M E P L F P A S T P S W N A S S P G A A S G G G D N R T L V G P A P S A N-termC-term L R K G S G A K D A D A T E P R P D R I R Q Q Q E A T P P A H R A A A N G L M Q T S K L C-term G A R A V L V P V L Y L L V C A A G L G G N T L V I Y V V L R F T V T N I Y I L N L A V A D V L Y M L G L P F L A T Q N A A G P V L C R L V M T L D G V N Q F T S V F C L T V M S V D R Y L A V V H R P R V A K L A S A A A W V L S L C M S L P L L V F A P V G L W G A V F I I Y T A V L G F F A P L L V I C L C Y L L I V V K V R A A G V R V R R S E R K V T R M V L V V V L V F A G C W L P F F T V N I V N L A V S A G L Y F F V V I L S Y A N S C A N P V L Y G F L S D N F Q K F R Q S V L C
Helix box plot — Download: PNG | SVG T N G G L G A A C V L L Y L V P V L V A 1 L N L A V A D V L Y M L G L P F L A T Q 2 V T L C F V S T F Q N V G D L T M V L R 3 A K L A S A A A W V L S L C M S L P L 4 Y C L C I V L L P A F F G L V A T Y I I F 5 L V V V L V F A G C W L P F F T V N I V 6 V P N A C S N A Y S L I V V F F Y L G 7

GPCRdb(A)
GPCRdb(A)
SST5 receptor
TM2
2x63 2.63x63 Q99
TM3
3x33 3.33x33 G120
3x36 3.36x36 Q123
3x37 3.37x37 F124
ECL2
45x51 45.51x51 N187
TM5
5x36 5.35x36 G198
5x39 5.38x39 F201
5x40 5.39x40 I202
5x43 5.42x43 T205
TM6
6x51 6.51x51 F264
6x55 6.55x55 N268
6x58 6.58x58 N271
TM7
7x34 7.35x34 Y286