PDB
8ZBI
Resolution
2.8 Å
Released
April 30, 2025
Receptor
SST3
Class
A
Species
Homo sapiens
Ligand
Function
SOMATOSTATIN
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
SOMATOSTATIN F93 2.53x53 TM2 Van der Waals
SOMATOSTATIN L100 2.60x60 TM2 hydrophobic
SOMATOSTATIN Q103 2.63x63 TM2 Van der Waals
SOMATOSTATIN N104 2.64x64 TM2 Van der Waals
SOMATOSTATIN S107 ECL1 Van der Waals
SOMATOSTATIN M120 3.29x29 TM3 Van der Waals
SOMATOSTATIN D123 3.32x32 TM3 polar (hydrogen bond)
SOMATOSTATIN D123 3.32x32 TM3 polar (charge-charge)
SOMATOSTATIN Q127 3.36x36 TM3 polar (hydrogen bond)
SOMATOSTATIN T190 ECL2 hydrophobic
SOMATOSTATIN C191 45.50x50 ECL2 Van der Waals
SOMATOSTATIN H192 45.51x51 ECL2 aromatic (pi-cation)
SOMATOSTATIN M193 45.52x52 ECL2 hydrophobic
SOMATOSTATIN W195 ECL2 aromatic (edge-to-face)
SOMATOSTATIN W195 ECL2 hydrophobic
SOMATOSTATIN R203 5.35x36 TM5 hydrophobic
SOMATOSTATIN F206 5.38x39 TM5 aromatic (edge-to-face)
SOMATOSTATIN F206 5.38x39 TM5 hydrophobic
SOMATOSTATIN I207 5.39x40 TM5 hydrophobic
SOMATOSTATIN T210 5.42x43 TM5 hydrophobic
SOMATOSTATIN F273 6.51x51 TM6 aromatic (edge-to-face)
SOMATOSTATIN F273 6.51x51 TM6 hydrophobic
SOMATOSTATIN N277 6.55x55 TM6 Van der Waals
SOMATOSTATIN N280 6.58x58 TM6 Van der Waals
SOMATOSTATIN L285 ECL3 Van der Waals
SOMATOSTATIN P286 ECL3 polar (hydrogen bond with backbone)
SOMATOSTATIN E287 ECL3 hydrophobic
SOMATOSTATIN F292 7.32x31 TM7 aromatic (edge-to-face)
SOMATOSTATIN F292 7.32x31 TM7 hydrophobic
SOMATOSTATIN Y295 7.35x34 TM7 hydrophobic
SOMATOSTATIN Y295 7.35x34 TM7 aromatic (face-to-face)
SOMATOSTATIN F296 7.36x35 TM7 hydrophobic
SOMATOSTATIN V299 7.39x38 TM7 hydrophobic
SOMATOSTATIN Y303 7.43x42 TM7 polar (hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 T A S P ICL1ECL1 Y W P F ECL1ICL2 P T R S A R W R ICL2ECL2 G V P R G M S T C H M Q W P E ECL2ICL3 W A P S C Q R ICL3ECL3 P L P E ECL3N-term M D M L H P S S V S T T S E P E N A S S A W P P D A T L G N V S A G P S P A G L A N-termC-term R P S R R V R S Q E P T V G P P E K T E E E D E E E E D G E E S R E G G K G K E M N G R V S Q I T Q P G T S G Q E R P P S R V A S K E Q Q L L P Q E A S T G E K S S T M R I S Y L C-term V S G V L I P L V Y L V V C V V G L L G N S L V I Y V V L R H S V T N V Y I L N L A L A D E L F M L G L P F L A A Q N A L S G S L M C R L V M A V D G I N Q F T S I F C L T V M S V D R Y L A V V H T A P V A R T V S A A V W V A S A V V V L P V V V F S P A A A W R A G F I I Y T A A L G F F G P L L V I C L C Y L L I V V K V R S A G R R V R R R S E R R V T R M V V A V V A L F V L C W M P F Y V L N I V N V V C E P A F F G L Y F L V V A L P Y A N S C A N P I L Y G F L S Y R F R R F K Q G V L L
Helix box plot — Download: PNG | SVG S N G L L G V V C V V L Y V L P I L V G 1 L N L A L A D E L F M L G L P F L A A Q 2 V T L C F I S T F Q N I G D V A M V L R 3 A R T V S A A V W V A S A V V V L P V 4 Y C L C I V L L P G F F G L A A T Y I I F 5 V A V V A L F V L C W M P F Y V L N I V 6 I P N A C S N A Y P L A V V L F Y L G 7

GPCRdb(A)
GPCRdb(A)
SST3 receptor
TM2
2x53 2.53x53 F93
2x60 2.60x60 L100
2x63 2.63x63 Q103
2x64 2.64x64 N104
TM3
3x29 3.29x29 M120
3x32 3.32x32 D123
3x36 3.36x36 Q127
ECL2
45x50 45.50x50 C191
45x51 45.51x51 H192
45x52 45.52x52 M193
TM5
5x36 5.35x36 R203
5x39 5.38x39 F206
5x40 5.39x40 I207
5x43 5.42x43 T210
TM6
6x51 6.51x51 F273
6x55 6.55x55 N277
6x58 6.58x58 N280
TM7
7x31 7.32x31 F292
7x34 7.35x34 Y295
7x35 7.36x35 F296
7x38 7.39x38 V299
7x42 7.43x42 Y303