PDB
8ZBJ
Resolution
2.9 Å
Released
April 30, 2025
Receptor
SST5
Class
A
Species
Homo sapiens
Ligand
Function
SOMATOSTATIN
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
SOMATOSTATIN L96 2.60x60 TM2 hydrophobic
SOMATOSTATIN Q99 2.63x63 TM2 Van der Waals
SOMATOSTATIN N100 2.64x64 TM2 Van der Waals
SOMATOSTATIN D119 3.32x32 TM3 polar (charge-charge)
SOMATOSTATIN Q123 3.36x36 TM3 Van der Waals
SOMATOSTATIN T185 ECL2 Van der Waals
SOMATOSTATIN N187 45.51x51 ECL2 polar (hydrogen bond)
SOMATOSTATIN A188 45.52x52 ECL2 Van der Waals
SOMATOSTATIN F201 5.38x39 TM5 aromatic (edge-to-face)
SOMATOSTATIN I202 5.39x40 TM5 Van der Waals
SOMATOSTATIN T205 5.42x43 TM5 hydrophobic
SOMATOSTATIN F264 6.51x51 TM6 aromatic (edge-to-face)
SOMATOSTATIN F264 6.51x51 TM6 hydrophobic
SOMATOSTATIN N268 6.55x55 TM6 Van der Waals
SOMATOSTATIN N271 6.58x58 TM6 Van der Waals
SOMATOSTATIN L272 6.59x59 TM6 Van der Waals
SOMATOSTATIN L276 ECL3 Van der Waals
SOMATOSTATIN P277 ECL3 hydrophobic
SOMATOSTATIN A283 7.32x31 TM7 hydrophobic
SOMATOSTATIN Y286 7.35x34 TM7 polar (hydrogen bond)
SOMATOSTATIN F287 7.36x35 TM7 hydrophobic
SOMATOSTATIN V290 7.39x38 TM7 Van der Waals
SOMATOSTATIN Y294 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 A K M K ICL1ECL1 S F W P F ECL1ICL2 P L S S A R W R ICL2ECL2 D V Q E G G T C N A S W P E ECL2ICL3 G C V R ICL3ECL3 A L P Q E P A ECL3N-term M E P L F P A S T P S W N A S S P G A A S G G G D N R T L V G P A P S A N-termC-term L R K G S G A K D A D A T E P R P D R I R Q Q Q E A T P P A H R A A A N G L M Q T S K L C-term G A R A V L V P V L Y L L V C A A G L G G N T L V I Y V V L R F T V T N I Y I L N L A V A D V L Y M L G L P F L A T Q N A A G P V L C R L V M T L D G V N Q F T S V F C L T V M S V D R Y L A V V H R P R V A K L A S A A A W V L S L C M S L P L L V F A P V G L W G A V F I I Y T A V L G F F A P L L V I C L C Y L L I V V K V R A A G V R V R R S E R K V T R M V L V V V L V F A G C W L P F F T V N I V N L A V S A G L Y F F V V I L S Y A N S C A N P V L Y G F L S D N F Q K F R Q S V L C
Helix box plot — Download: PNG | SVG T N G G L G A A C V L L Y L V P V L V A 1 L N L A V A D V L Y M L G L P F L A T Q 2 V T L C F V S T F Q N V G D L T M V L R 3 A K L A S A A A W V L S L C M S L P L 4 Y C L C I V L L P A F F G L V A T Y I I F 5 L V V V L V F A G C W L P F F T V N I V 6 V P N A C S N A Y S L I V V F F Y L G 7

GPCRdb(A)
GPCRdb(A)
SST5 receptor
TM2
2x60 2.60x60 L96
2x63 2.63x63 Q99
2x64 2.64x64 N100
TM3
3x32 3.32x32 D119
3x36 3.36x36 Q123
ECL2
45x51 45.51x51 N187
45x52 45.52x52 A188
TM5
5x39 5.38x39 F201
5x40 5.39x40 I202
5x43 5.42x43 T205
TM6
6x51 6.51x51 F264
6x55 6.55x55 N268
6x58 6.58x58 N271
6x59 6.59x59 L272
TM7
7x31 7.32x31 A283
7x34 7.35x34 Y286
7x35 7.36x35 F287
7x38 7.39x38 V290
7x42 7.43x42 Y294