PDB
8ZBW
Resolution
2.6 Å
Released
Sept. 10, 2025
Receptor
FPR2/ALX
Class
A
Species
Homo sapiens
Ligand
Function
Quin-C1
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
Quin-C1 L81 2.60x60 TM2 Van der Waals
Quin-C1 H102 3.29x29 TM3 Van der Waals
Quin-C1 V105 3.32x32 TM3 hydrophobic
Quin-C1 D106 3.33x33 TM3 polar (hydrogen bond)
Quin-C1 L109 3.36x36 TM3 hydrophobic
Quin-C1 F110 3.37x37 TM3 aromatic (edge-to-face)
Quin-C1 F110 3.37x37 TM3 hydrophobic
Quin-C1 V113 3.40x40 TM3 Van der Waals
Quin-C1 L156 4.56x56 TM4 Van der Waals
Quin-C1 P159 4.59x60 TM4 Van der Waals
Quin-C1 M197 5.34x35 TM5 Van der Waals
Quin-C1 A200 5.37x38 TM5 Van der Waals
Quin-C1 R201 5.38x39 TM5 hydrophobic
Quin-C1 R201 5.38x39 TM5 polar (hydrogen bond)
Quin-C1 I204 5.41x42 TM5 hydrophobic
Quin-C1 R205 5.42x43 TM5 polar (hydrogen bond)
Quin-C1 R205 5.42x43 TM5 hydrophobic
Quin-C1 G209 5.46x461 TM5 Van der Waals
Quin-C1 W254 6.48x48 TM6 hydrophobic
Quin-C1 F257 6.51x51 TM6 hydrophobic
Quin-C1 Q258 6.52x52 TM6 polar (hydrogen bond)
Quin-C1 F292 7.43x42 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 T R ICL1ECL1 E K W P F ECL1ICL2 P V W A Q N H R ICL2ECL2 T T V T I P N G D T Y C T F N F A S W G G ECL2ICL3 M I K S ICL3ECL3 L K E M L F Y G K ECL3N-term M E T N F S T P L N E Y E E V S Y E N-termC-term P T S L E R A L S E D S A P T N D T A A N S A S P P A E T E L Q A M C-term S A G Y T V L R I L P L V V L G V T F V L G V L G N G L V I W V A G F R M T V T T I C Y L N L A L A D F S F T A T L P F L I V S M A M G G W F L C K L I H I V V D I N L F G S V F L I G F I A L D R C I C V L H T V S L A M K V I V G P W I L A L V L T L P V F L F L T P E E R L K V A I T M L T A R G I I R F V I G F S L P M S I V A I C Y G L I A A K I H K K G S R P L R V L T A V V A S F F I C W F P F Q L V A L L G T V W Y K I I D I L V N P T S S L A F F N S C L N P M L Y V F V G Q D L I H F R E R S L
Helix box plot — Download: PNG | SVG G N G L V G L V F T V G L V V L P L I R 1 L N L A L A D F S F T A T L P F L I V S 2 F G I L F V S G F L N I D V V I H I L K 3 A M K V I V G P W I L A L V L T L P V 4 Y C I A V I S M P L S F G I V F R I I G R 5 T A V V A S F F I C W F P F Q L V A L L 6 M P N L C S N F F A L S S T P N V L I 7

GPCRdb(A)
GPCRdb(A)
FPR2/ALX
TM2
2x60 2.60x60 L81
TM3
3x29 3.29x29 H102
3x32 3.32x32 V105
3x33 3.33x33 D106
3x36 3.36x36 L109
3x37 3.37x37 F110
3x40 3.40x40 V113
TM4
4x56 4.56x56 L156
4x60 4.59x60 P159
TM5
5x35 5.34x35 M197
5x38 5.37x38 A200
5x39 5.38x39 R201
5x42 5.41x42 I204
5x43 5.42x43 R205
5x461 5.46x461 G209
TM6
6x48 6.48x48 W254
6x51 6.51x51 F257
6x52 6.52x52 Q258
TM7
7x42 7.43x42 F292