PDB
8ZCJ
Resolution
3.1 Å
Released
July 10, 2024
Receptor
SST5
Class
A
Species
Homo sapiens
Ligand
Function
pasireotide
Agonist
Reference
10.1038/S41401-024-01314-8

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Ligand Amino Acid Generic Number Segment Interaction Type
pasireotide Y89 2.53x53 TM2 polar (hydrogen bond)
pasireotide L96 2.60x60 TM2 Van der Waals
pasireotide Q99 ECL1 polar (hydrogen bond)
pasireotide M116 3.29x29 TM3 hydrophobic
pasireotide D119 3.32x32 TM3 polar (charge-charge)
pasireotide G120 3.33x33 TM3 Van der Waals
pasireotide Q123 3.36x36 TM3 Van der Waals
pasireotide F124 3.37x37 TM3 hydrophobic
pasireotide T185 ECL2 hydrophobic
pasireotide F201 5.38x39 TM5 hydrophobic
pasireotide F201 5.38x39 TM5 aromatic (edge-to-face)
pasireotide I202 5.39x40 TM5 hydrophobic
pasireotide T205 5.42x43 TM5 hydrophobic
pasireotide F264 6.51x51 TM6 hydrophobic
pasireotide N268 6.55x55 TM6 polar (hydrogen bond)
pasireotide N271 6.58x58 TM6 Van der Waals
pasireotide L272 6.59x59 TM6 hydrophobic
pasireotide Q278 ECL3 hydrophobic
pasireotide S282 7.31x30 TM7 Van der Waals
pasireotide A283 7.32x31 TM7 Van der Waals
pasireotide Y286 7.35x34 TM7 Van der Waals
pasireotide V290 7.39x38 TM7 Van der Waals
pasireotide S293 7.42x41 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 A K M K ICL1ECL1 S F W P F ECL1ICL2 P L S S A R W R ICL2ECL2 D V Q E G G T C N A S W P E ECL2ICL3 G C V R ICL3ECL3 A L P Q E P A ECL3N-term M E P L F P A S T P S W N A S S P G A A S G G G D N R T L V G P A P S A N-termC-term L R K G S G A K D A D A T E P R P D R I R Q Q Q E A T P P A H R A A A N G L M Q T S K L C-term G A R A V L V P V L Y L L V C A A G L G G N T L V I Y V V L R F T V T N I Y I L N L A V A D V L Y M L G L P F L A T Q N A A G P V L C R L V M T L D G V N Q F T S V F C L T V M S V D R Y L A V V H R P R V A K L A S A A A W V L S L C M S L P L L V F A P V G L W G A V F I I Y T A V L G F F A P L L V I C L C Y L L I V V K V R A A G V R V R R S E R K V T R M V L V V V L V F A G C W L P F F T V N I V N L A V S A G L Y F F V V I L S Y A N S C A N P V L Y G F L S D N F Q K F R Q S V L C
Helix box plot — Download: PNG | SVG T N G G L G A A C V L L Y L V P V L V A 1 L N L A V A D V L Y M L G L P F L A T Q 2 V T L C F V S T F Q N V G D L T M V L R 3 A K L A S A A A W V L S L C M S L P L 4 Y C L C I V L L P A F F G L V A T Y I I F 5 L V V V L V F A G C W L P F F T V N I V 6 V P N A C S N A Y S L I V V F F Y L G 7

GPCRdb(A)
GPCRdb(A)
SST5 receptor
TM2
2x53 2.53x53 Y89
2x60 2.60x60 L96
TM3
3x29 3.29x29 M116
3x32 3.32x32 D119
3x33 3.33x33 G120
3x36 3.36x36 Q123
3x37 3.37x37 F124
TM5
5x39 5.38x39 F201
5x40 5.39x40 I202
5x43 5.42x43 T205
TM6
6x51 6.51x51 F264
6x55 6.55x55 N268
6x58 6.58x58 N271
6x59 6.59x59 L272
TM7
7x30 7.31x30 S282
7x31 7.32x31 A283
7x34 7.35x34 Y286
7x38 7.39x38 V290
7x41 7.42x41 S293