PDB
8ZQE
Resolution
2.9 Å
Released
July 10, 2024
Receptor
GPR15
Class
A
Species
Homo sapiens
Ligand
GPR15LC11
Function
Agonist
Reference
10.1038/S41421-024-00698-5

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Ligand Amino Acid Generic Number Segment Interaction Type
GPR15LC11 Y40 1.39x39 TM1 Van der Waals
GPR15LC11 Y40 1.39x39 TM1 polar (hydrogen bond)
GPR15LC11 W89 2.60x60 TM2 hydrophobic
GPR15LC11 W89 2.60x60 TM2 Van der Waals
GPR15LC11 K92 2.63x63 TM2 polar (charge-assisted hydrogen bond)
GPR15LC11 I113 3.32x32 TM3 hydrophobic
GPR15LC11 I113 3.32x32 TM3 Van der Waals
GPR15LC11 S114 3.33x33 TM3 Van der Waals
GPR15LC11 M117 3.36x36 TM3 Van der Waals
GPR15LC11 M117 3.36x36 TM3 hydrophobic
GPR15LC11 R172 4.64x64 TM4 Van der Waals
GPR15LC11 C183 45.50x50 ECL2 Van der Waals
GPR15LC11 C183 45.50x50 ECL2 hydrophobic
GPR15LC11 A184 45.51x51 ECL2 hydrophobic
GPR15LC11 A184 45.51x51 ECL2 Van der Waals
GPR15LC11 E185 45.52x52 ECL2 polar (hydrogen bond with backbone)
GPR15LC11 E185 45.52x52 ECL2 Van der Waals
GPR15LC11 K186 ECL2 Van der Waals
GPR15LC11 K187 ECL2 polar (hydrogen bond with backbone)
GPR15LC11 K187 ECL2 Van der Waals
GPR15LC11 S196 5.39x40 TM5 Van der Waals
GPR15LC11 S196 5.39x40 TM5 polar (hydrogen bond)
GPR15LC11 F257 6.51x51 TM6 Van der Waals
GPR15LC11 F257 6.51x51 TM6 hydrophobic
GPR15LC11 K261 6.55x55 TM6 polar (charge-assisted hydrogen bond)
GPR15LC11 I265 6.59x59 TM6 Van der Waals
GPR15LC11 M284 7.35x34 TM7 Van der Waals
GPR15LC11 M284 7.35x34 TM7 hydrophobic
GPR15LC11 G288 7.39x38 TM7 Van der Waals
GPR15LC11 A291 7.42x41 TM7 hydrophobic
GPR15LC11 F292 7.43x42 TM7 Van der Waals
GPR15LC11 F292 7.43x42 TM7 hydrophobic

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ICL1 P G S R ICL1ECL1 G L W R T ECL1ICL2 P V V S R K F R ICL2ECL2 E L T L I D D K P Y C A E K K A ECL2ICL3 Y Q Q S G K H N K ICL3ECL3 G L R Q E ECL3N-term M D P E E T S V Y L D Y Y Y A T S P N S D I R E T N-termC-term K N Y D F G S S T E T S D S H L T K A L S T F I H A E D F A R R R K R S V S L C-term H S H V P Y T S V F L P V F Y T A V F L T G V L G N L V L M G A L H F K R L I D I F I I N L A A S D F I F L V T L P L W V D K E A S L G S F L C K G S S Y M I S V N M H C S V L L L T C M S V D R Y L A I V W R T D C A Y V V C A S I W F I S C L L G L P T L L S R T P I K L I W S L V A L I F T F F V P L L S I V T C Y C C I A R K L C A H K L K K S I K I I F I V V A A F L V S W L P F N T F K F L A I V S H Y L P S A I L Q L G M E V S G P L A F A N S C V N P F I Y Y I F D S Y I V H C L I R R A C L C P
Helix box plot — Download: PNG | SVG L N G L V G T L F V A T Y F V P L F V S 1 I N L A A S D F I F L V T L P L W V D K 2 C T L L L V S C H M N V S I M Y S S G K 3 A Y V V C A S I W F I S C L L G L P T L 4 Y C T V I S L L P V F F T F I L A V L S W 5 F I V V A A F L V S W L P F N T F K F L 6 F P N V C S N A F A L P G S V E M G L 7

GPCRdb(A)
GPCRdb(A)
GPR15
TM1
1x39 1.39x39 Y40
TM2
2x60 2.60x60 W89
2x63 2.63x63 K92
TM3
3x32 3.32x32 I113
3x33 3.33x33 S114
3x36 3.36x36 M117
TM4
4x64 4.64x64 R172
ECL2
45x50 45.50x50 C183
45x51 45.51x51 A184
45x52 45.52x52 E185
TM5
5x40 5.39x40 S196
TM6
6x51 6.51x51 F257
6x55 6.55x55 K261
6x59 6.59x59 I265
TM7
7x34 7.35x34 M284
7x38 7.39x38 G288
7x41 7.42x41 A291
7x42 7.43x42 F292