Structure information

ETB receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8ZRT

SPECIES

Homo sapiens

RESOLUTION

3.620

PREFERRED CHAIN

R

REFERENCE

10.1038/S42003-024-06905-Z

PUBLICATION DATE

Oct. 2, 2024

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
ENDOTHELIN I94 N-term hydrophobic
ENDOTHELIN K161 2.64x63 TM2 polar (charge-assisted hydrogen bond)
ENDOTHELIN E165 ECL1 polar (hydrogen bond with backbone)
ENDOTHELIN E165 ECL1 Van der Waals
ENDOTHELIN D166 23.49x49 ECL1 Van der Waals
ENDOTHELIN W167 23.50x50 ECL1 hydrophobic
ENDOTHELIN Q181 3.32x32 TM3 polar (hydrogen bond)
ENDOTHELIN Q181 3.32x32 TM3 Van der Waals
ENDOTHELIN K182 3.33x33 TM3 polar (charge-assisted hydrogen bond)
ENDOTHELIN V185 3.36x36 TM3 hydrophobic
ENDOTHELIN Y247 ECL2 Van der Waals
ENDOTHELIN Y247 ECL2 aromatic (face-to-edge)
ENDOTHELIN L252 ECL2 Van der Waals
ENDOTHELIN I254 ECL2 hydrophobic
ENDOTHELIN I254 ECL2 Van der Waals
ENDOTHELIN L257 45.52x52 ECL2 Van der Waals
ENDOTHELIN P259 ECL2 Van der Waals
ENDOTHELIN P259 ECL2 hydrophobic
ENDOTHELIN K270 5.35x36 TM5 Van der Waals
ENDOTHELIN K273 5.38x39 TM5 Van der Waals
ENDOTHELIN L277 5.42x43 TM5 hydrophobic
ENDOTHELIN L277 5.42x43 TM5 Van der Waals
ENDOTHELIN W336 6.48x48 TM6 Van der Waals
ENDOTHELIN W336 6.48x48 TM6 hydrophobic
ENDOTHELIN R343 6.55x55 TM6 polar (charge-assisted hydrogen bond)
ENDOTHELIN R357 7.24x23 TM7 Van der Waals
ENDOTHELIN L365 7.32x31 TM7 Van der Waals
ENDOTHELIN L365 7.32x31 TM7 hydrophobic
ENDOTHELIN D368 7.35x34 TM7 polar (charge-assisted hydrogen bond)
ENDOTHELIN Y369 7.36x35 TM7 polar (hydrogen bond)
ENDOTHELIN Y369 7.36x35 TM7 Van der Waals
ENDOTHELIN I372 7.39x38 TM7 Van der Waals
ENDOTHELIN I372 7.39x38 TM7 hydrophobic

Ligands

ENDOTHELIN

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Residue Diagrams

S N G I I G L V F V L C S V V T N I Y K 1 A S L A L G D L L H I I V D I P I N V Y K 2 A C L S L V T I G V S A K Q I F P V L K 3 T A V E I V L I W V V S V V L A V P E 4 Y F F A T I A L P L C F Y F S F L W W D K 5 F C L V L V F A L C W L P L H L S R I L 6 I P N I C S N L S A M N I G I Y D L V 7
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ICL1 K C M R N ICL1ECL1 E D W P F ECL1ICL2 W S R I K G I G ICL2ECL2 D I I T M D Y K G S Y L R I C L L H P V Q K ECL2ICL3 Q I A L ICL3ECL3 N Q N D P N ECL3N-term M Q P P P S L C G R A L V A L V L A C G L S R I W G E E R G F P P D R A T P L L Q T A E I M T P P T K T L W P K G S N A S L A R S L A P A E V P K G D R T A G S P P R T I S P P P C N-termC-term W C Q S F E E K Q S L E E K Q S C L K F K A N D H G Y D N F R S S N K Y S S S C-term Q G P I E I K E T F K Y I N T V V S C L V F V L G I I G N S T L L R I I Y K N G P N I L I A S L A L G D L L H I V I D I P I N V Y K L L A G A E M C K L V P F I Q K A S V G I T V L S L C A L S I D R Y R A V A S V P K W T A V E I V L I W V V S V V L A V P E A I G F T A F M Q F Y K T A K D W W L F S F Y F C L P L A I T A F F Y T L M T C E M L R K K S G M N D H L K Q R R E V A K T V F C L V L V F A L C W L P L H L S R I L K L T L Y R C E L L S F L L V L D Y I G I N M A S L N S C I N P I A L Y L V S K R F K S F K N C C L C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
ETB receptor
TM2
2x63 2.64x63 K161
ECL1
23x49 23.49x49 D166
23x50 23.50x50 W167
TM3
3x32 3.32x32 Q181
3x33 3.33x33 K182
3x36 3.36x36 V185
ECL2
45x52 45.52x52 L257
TM5
5x36 5.35x36 K270
5x39 5.38x39 K273
5x43 5.42x43 L277
TM6
6x48 6.48x48 W336
6x55 6.55x55 R343
TM7
7x23 7.24x23 R357
7x31 7.32x31 L365
7x34 7.35x34 D368
7x35 7.36x35 Y369
7x38 7.39x38 I372