PDB
8ZSP
Resolution
3.1 Å
Released
July 24, 2024
Receptor
TA1
Class
A
Species
Homo sapiens
Ligand
Function
(+)-LSD
Agonist
Reference
10.1016/J.CELREP.2024.114505

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Ligand Amino Acid Generic Number Segment Interaction Type
(+)-LSD R83 2.64x63 TM2 Van der Waals
(+)-LSD H99 3.28x28 TM3 Van der Waals
(+)-LSD T100 3.29x29 TM3 Van der Waals
(+)-LSD D103 3.32x32 TM3 polar (charge-charge)
(+)-LSD D103 3.32x32 TM3 polar (hydrogen bond)
(+)-LSD I104 3.33x33 TM3 hydrophobic
(+)-LSD S107 3.36x36 TM3 Van der Waals
(+)-LSD S108 3.37x37 TM3 Van der Waals
(+)-LSD S183 45.51x51 ECL2 Van der Waals
(+)-LSD V184 45.52x52 ECL2 Van der Waals
(+)-LSD F186 ECL2 hydrophobic
(+)-LSD T194 5.42x43 TM5 hydrophobic
(+)-LSD S198 5.46x461 TM5 polar (hydrogen bond)
(+)-LSD W264 6.48x48 TM6 hydrophobic
(+)-LSD W264 6.48x48 TM6 aromatic (edge-to-face)
(+)-LSD F267 6.51x51 TM6 aromatic (edge-to-face)
(+)-LSD F267 6.51x51 TM6 hydrophobic
(+)-LSD F268 6.52x52 TM6 hydrophobic
(+)-LSD F268 6.52x52 TM6 aromatic (edge-to-face)
(+)-LSD N286 7.35x34 TM7 Van der Waals
(+)-LSD I290 7.39x38 TM7 hydrophobic
(+)-LSD Y294 7.43x42 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 K Q L H ICL1ECL1 C W Y F ECL1ICL2 P L R Y K A K M ICL2ECL2 L N F K G A E E I Y Y K H V H C R G G C S V F F ECL2ICL3 I G L E M K ICL3ECL3 H Y I I ECL3N-term M M P F C H N I I N I S C V K N N W S N N-termC-term G K I F Q K D S S R C K L F L E L S S C-term D V R A S L Y S L M V L I I L T T L V G N L I V I V S I S H F T P T N W L I H S M A T V D F L L G C L V M P Y S M V R S A E H G E V F C K I H T S T D I M L S S A S I F H L S F I S I D R Y Y A V C D N I L V I C V M I F I S W S V P A V F A F G M I F L E S K I S G V L T F M T S F Y I P G S I M L C V Y Y R I Y L I A K E Q A R L I S D A N Q K L Q N G I S Q S K E R K A V K T L G I V M G V F L I C W C P F F I C T V M D P F L P P T L N D V L I W F G Y L N S T F N P M V Y A F F Y P W L K M F R K A M L F
Helix box plot — Download: PNG | SVG L N G V L T T L I I L V M L S Y L S A R 1 H S M A T V D F L L G L C V M P Y S M V R 2 F S L H F I S A S S L M I D T S T H I K 3 I C V M I F I S W S V P A V F A F G M I 4 Y V C L M I S G P I Y F S T M F T L V G S 5 G I V M G V F L I C W C P F F I C T V M 6 M P N F T S N L Y G F W I L V D N L T 7

GPCRdb(A)
GPCRdb(A)
TA1 receptor
TM2
2x63 2.64x63 R83
TM3
3x28 3.28x28 H99
3x29 3.29x29 T100
3x32 3.32x32 D103
3x33 3.33x33 I104
3x36 3.36x36 S107
3x37 3.37x37 S108
ECL2
45x51 45.51x51 S183
45x52 45.52x52 V184
TM5
5x43 5.42x43 T194
5x461 5.46x461 S198
TM6
6x48 6.48x48 W264
6x51 6.51x51 F267
6x52 6.52x52 F268
TM7
7x34 7.35x34 N286
7x38 7.39x38 I290
7x42 7.43x42 Y294