PDB
8ZWG
Resolution
2.9 Å
Released
May 14, 2025
Receptor
C3a
Class
A
Species
Homo sapiens
Ligand
Function
JR14a
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
JR14a S26 1.35x35 TM1 Van der Waals
JR14a L30 1.39x39 TM1 hydrophobic
JR14a F77 2.59x59 TM2 Van der Waals
JR14a S78 2.60x60 TM2 Van der Waals
JR14a H81 2.63x63 TM2 hydrophobic
JR14a L82 2.64x64 TM2 hydrophobic
JR14a W88 23.50x50 ECL1 hydrophobic
JR14a I98 3.28x28 TM3 hydrophobic
JR14a I102 3.32x32 TM3 hydrophobic
JR14a V103 3.33x33 TM3 Van der Waals
JR14a M106 3.36x36 TM3 hydrophobic
JR14a R161 ECL2 polar (charge-charge)
JR14a Y174 45.52x52 ECL2 Van der Waals
JR14a R340 5.42x43 TM5 polar (charge-charge)
JR14a Y393 6.51x51 TM6 polar (hydrogen bond with backbone)
JR14a Y393 6.51x51 TM6 polar (hydrogen bond)
JR14a Y393 6.51x51 TM6 aromatic (pi-cation)
JR14a Y393 6.51x51 TM6 hydrophobic
JR14a F396 6.54x54 TM6 Van der Waals
JR14a G397 6.55x55 TM6 Van der Waals
JR14a D417 7.35x34 TM7 polar (hydrogen bond)
JR14a D417 7.35x34 TM7 polar (charge-charge)
JR14a H418 7.36x35 TM7 hydrophobic
JR14a I421 7.39x38 TM7 hydrophobic
JR14a A422 7.40x39 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 M Q R ICL1ECL1 G Q W P Y ECL1ICL2 P I W C Q N H R ICL2ECL2 E I F T T D N H N R C G Y K F G L S S S L D Y P D F Y G D P L E N R S L E N I V Q P P G E M N D R L D P S S F Q T N D H P W T V P T V F Q P Q T F Q R P S A D S L P R G S A R L T S Q N L Y S N V F K P A D V V S P K I P S G F P I E D H E T S P L D N S D A F L S T H L K L F P S A S S N S F Y E S E L P Q G F Q D Y Y N L G Q F T D D D Q ECL2ICL3 G R F A K S Q ICL3ECL3 D P E ECL3N-term M A S F S A E T N S T D L L S Q P W N N-termC-term S I Q G I L E A A F S E E L T R S T H C P S N N V I S E R N S T T V C-term E P P V I L S M V I L S L T F L L G L P G N G L V L W V A G L K T V N T I W F L H L T L A D L L C C L S L P F S L A H L A L Q G R F L C K L I P S I I V L N M F A S V F L L T A I S L D R C L V V F K N V G M A C S I C G C I W V V A F V M C I P V F V Y R V P T P L V A I T I T R L V V G F L L P S V I M I A C Y S F I V F R M Q R S K T F R V A V V V V A V F L V C W T P Y H I F G V L S L L T T P L G K T L M S W D H V C I A L A S A N S C F N P F L Y A L L G K D A R Q F R K K
Helix box plot — Download: PNG | SVG G N G P L G L L F T L S L I V M S L I V 1 L H L T L A D L L C C L S L P F S L A H 2 A T L L F V S A F M N L V I I S P I L K 3 A C S I C G C I W V V A F V M C I P V 4 Y C A I M I V S P L L F G V V L R T I T I 5 V V V V A V F L V C W T P Y H I F G V L 6 F P N F C S N A S A L A I C V H D W S 7

GPCRdb(A)
GPCRdb(A)
C3a receptor
TM1
1x35 1.35x35 S26
1x39 1.39x39 L30
TM2
2x59 2.59x59 F77
2x60 2.60x60 S78
2x63 2.63x63 H81
2x64 2.64x64 L82
ECL1
23x50 23.50x50 W88
TM3
3x28 3.28x28 I98
3x32 3.32x32 I102
3x33 3.33x33 V103
3x36 3.36x36 M106
ECL2
45x52 45.52x52 Y174
TM5
5x43 5.42x43 R340
TM6
6x51 6.51x51 Y393
6x54 6.54x54 F396
6x55 6.55x55 G397
TM7
7x34 7.35x34 D417
7x35 7.36x35 H418
7x38 7.39x38 I421
7x39 7.40x39 A422