PDB
8ZX4
Resolution
2.9 Å
Released
Nov. 13, 2024
Receptor
GPR55
Class
A
Species
Homo sapiens
Ligand
L-alpha-lysophosphatidylinositol (16:0)
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
L-alpha-lysophosphatidylinositol (16:0) F12 1.24x24 TM1 hydrophobic
L-alpha-lysophosphatidylinositol (16:0) N16 1.28x28 TM1 Van der Waals
L-alpha-lysophosphatidylinositol (16:0) N16 1.28x28 TM1 polar (hydrogen bond)
L-alpha-lysophosphatidylinositol (16:0) F102 3.33x33 TM3 Van der Waals
L-alpha-lysophosphatidylinositol (16:0) F102 3.33x33 TM3 hydrophobic
L-alpha-lysophosphatidylinositol (16:0) Y106 3.37x37 TM3 hydrophobic
L-alpha-lysophosphatidylinositol (16:0) Y106 3.37x37 TM3 Van der Waals
L-alpha-lysophosphatidylinositol (16:0) F110 3.41x41 TM3 Van der Waals
L-alpha-lysophosphatidylinositol (16:0) F110 3.41x41 TM3 hydrophobic
L-alpha-lysophosphatidylinositol (16:0) L148 4.52x52 TM4 hydrophobic
L-alpha-lysophosphatidylinositol (16:0) L148 4.52x52 TM4 Van der Waals
L-alpha-lysophosphatidylinositol (16:0) V149 4.53x53 TM4 Van der Waals
L-alpha-lysophosphatidylinositol (16:0) V149 4.53x53 TM4 hydrophobic
L-alpha-lysophosphatidylinositol (16:0) G152 4.56x56 TM4 Van der Waals
L-alpha-lysophosphatidylinositol (16:0) I156 4.60x61 TM4 Van der Waals
L-alpha-lysophosphatidylinositol (16:0) I156 4.60x61 TM4 hydrophobic
L-alpha-lysophosphatidylinositol (16:0) F159 4.63x64 TM4 Van der Waals
L-alpha-lysophosphatidylinositol (16:0) F159 4.63x64 TM4 hydrophobic
L-alpha-lysophosphatidylinositol (16:0) F169 45.51x51 ECL2 Van der Waals
L-alpha-lysophosphatidylinositol (16:0) F169 45.51x51 ECL2 polar (hydrogen bond with backbone)
L-alpha-lysophosphatidylinositol (16:0) H170 45.52x52 ECL2 Van der Waals
L-alpha-lysophosphatidylinositol (16:0) H170 45.52x52 ECL2 polar (hydrogen bond)
L-alpha-lysophosphatidylinositol (16:0) N171 ECL2 Van der Waals
L-alpha-lysophosphatidylinositol (16:0) N171 ECL2 polar (hydrogen bond with backbone)
L-alpha-lysophosphatidylinositol (16:0) N171 ECL2 polar (hydrogen bond)
L-alpha-lysophosphatidylinositol (16:0) M172 ECL2 polar (hydrogen bond with backbone)
L-alpha-lysophosphatidylinositol (16:0) M172 ECL2 Van der Waals
L-alpha-lysophosphatidylinositol (16:0) W177 ECL2 polar (hydrogen bond)
L-alpha-lysophosphatidylinositol (16:0) W177 ECL2 Van der Waals
L-alpha-lysophosphatidylinositol (16:0) L185 5.42x43 TM5 Van der Waals
L-alpha-lysophosphatidylinositol (16:0) L185 5.42x43 TM5 hydrophobic
L-alpha-lysophosphatidylinositol (16:0) F246 6.55x55 TM6 hydrophobic
L-alpha-lysophosphatidylinositol (16:0) F246 6.55x55 TM6 Van der Waals
L-alpha-lysophosphatidylinositol (16:0) Q249 6.58x58 TM6 Van der Waals
L-alpha-lysophosphatidylinositol (16:0) R253 6.62x62 TM6 polar (charge-assisted hydrogen bond)
L-alpha-lysophosphatidylinositol (16:0) L270 7.35x34 TM7 hydrophobic
L-alpha-lysophosphatidylinositol (16:0) L270 7.35x34 TM7 Van der Waals
L-alpha-lysophosphatidylinositol (16:0) M274 7.39x38 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 W P D Y ICL1ECL1 Q S P ECL1ICL2 P L L V S H L R ICL2ECL2 K Y M C F H N M S D D T W ECL2ICL3 T Q D W V Q ICL3ECL3 F I V ECL3N-term M S Q Q N T S G D C L N-termC-term V Q L V L Q D T T I S R G C-term F D G V N E L M K T L Q F A V H I P T F V L G L L L N L L A I H G F S T F L K N R A A T S I Y M I N L A V F D L L L V L S L P F K M V L S Q V F P S L C T L V E C L Y F V S M Y G S V F T I C F I S M D R F L A I R Y S P R K I F G I C C T I W V L V W T G S I P I Y S F H G K V E S A K V F F P L E V F G F L L P M G I M G F C C S R S I H I L L G R R D H Q K A C I Y S I A A S L A V F V V S F L P V H L G F F L Q F L V R N S E C R A K Q S I S F F L Q L S M C F S N V N C C L D V F C Y Y F V I K E I R A R F R M N H R P S
Helix box plot — Download: PNG | SVG L N L L L G L V F T P I H V A F Q L T K 1 I N L A V F D L L L V L S L P F K M V L 2 F C I T F V S G Y M S V F Y L C E V L T 3 I F G I C C T I W V L V W T G S I P I 4 C C F G M I G M P L L F G F V E L P F F V 5 A A S L A V F V V S F L P V H L G F F L 6 F V D L C C N V N S F C M S L Q L F F 7

GPCRdb(A)
GPCRdb(A)
GPR55
TM1
1x24 1.24x24 F12
1x28 1.28x28 N16
TM3
3x33 3.33x33 F102
3x37 3.37x37 Y106
3x41 3.41x41 F110
TM4
4x52 4.52x52 L148
4x53 4.53x53 V149
4x56 4.56x56 G152
4x61 4.60x61 I156
4x64 4.63x64 F159
ECL2
45x51 45.51x51 F169
45x52 45.52x52 H170
TM5
5x43 5.42x43 L185
TM6
6x55 6.55x55 F246
6x58 6.58x58 Q249
6x62 6.62x62 R253
TM7
7x34 7.35x34 L270
7x38 7.39x38 M274