PDB
9AS2
Resolution
3.2 Å
Released
April 2, 2025
Receptor
5-HT2A
Class
A
Species
Homo sapiens
Ligand
dimethyltryptamine
Function
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
dimethyltryptamine D155 3.32x32 TM3 polar (charge-assisted hydrogen bond)
dimethyltryptamine V156 3.33x33 TM3 hydrophobic
dimethyltryptamine V156 3.33x33 TM3 Van der Waals
dimethyltryptamine S159 3.36x36 TM3 Van der Waals
dimethyltryptamine T160 3.37x37 TM3 Van der Waals
dimethyltryptamine L229 45.52x52 ECL2 Van der Waals
dimethyltryptamine L229 45.52x52 ECL2 hydrophobic
dimethyltryptamine S242 5.46x461 TM5 polar (hydrogen bond)
dimethyltryptamine S242 5.46x461 TM5 Van der Waals
dimethyltryptamine W336 6.48x48 TM6 Van der Waals
dimethyltryptamine W336 6.48x48 TM6 hydrophobic
dimethyltryptamine F339 6.51x51 TM6 hydrophobic
dimethyltryptamine F339 6.51x51 TM6 Van der Waals
dimethyltryptamine F340 6.52x52 TM6 Van der Waals
dimethyltryptamine F340 6.52x52 TM6 aromatic (edge-to-face)

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ICL1 K K L Q ICL1ECL1 Y R W P L ECL1ICL2 P I H H S R F N ICL2ECL2 D S K V F K E G S C L L A ECL2ICL3 G T R A K L A S F S F L P Q S S L S S E K L F Q R S I H R E P G S Y T G R R T ICL3ECL3 K E S C ECL3N-term M D I L C E E N T S L S S T T N S L M Q L N D D T R L Y S N D F N S G E A N T S D A F N W T V D S E N R T N L S C E G C L S P S C L S L N-termC-term Q Y K E N K K P L Q L I L V N T I P A L A Y K S S Q L Q M G Q K K N S K Q D A K T T D N D C S M V A L G K Q H S E E A S K D N S D G V N E K V S C V C-term L H L Q E K N W S A L L T A V V I I L T I A G N I L V I M A V S L E N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N S R T K A F L K I I A V W T I S V G I S M P I P V F G L Q D D D N F V L I G S F V S F F I P L T I M V I T Y F L T I K S L Q K E A T L C V S D L M Q S I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C N E D V I G A L L N V F V W I G Y L S S A V N P L V Y T L F N K T F S R Y R S A Y I Q C
Helix box plot — Download: PNG | SVG I N G A I T L I I V V A T L L A S W N K 1 M S L A I A D M L L G L F V M P V S M L T 2 A C L H M I S A T S F L V D L Y I W V A 3 A F L K I I A V W T I S V G I S M P I 4 Y T I V M I T L P I F F S V F S G I L V F 5 G I V F F L F V V M W C P F F I T N I M 6 L P N V A S S L Y G I W V F V N L L A 7

GPCRdb(A)
GPCRdb(A)
5-HT2A receptor
TM3
3x32 3.32x32 D155
3x33 3.33x33 V156
3x36 3.36x36 S159
3x37 3.37x37 T160
ECL2
45x52 45.52x52 L229
TM5
5x461 5.46x461 S242
TM6
6x48 6.48x48 W336
6x51 6.51x51 F339
6x52 6.52x52 F340