PDB
9B9Z
Resolution
3.3 Å
Released
Nov. 20, 2024
Receptor
CB1
Class
A
Species
Homo sapiens
Ligand
Function
MRI-1867
Inverse agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
MRI-1867 F102 N-term hydrophobic
MRI-1867 M103 N-term hydrophobic
MRI-1867 D104 N-term Van der Waals
MRI-1867 I105 N-term hydrophobic
MRI-1867 I119 1.35x35 TM1 Van der Waals
MRI-1867 L122 1.38x38 TM1 Van der Waals
MRI-1867 S123 1.39x39 TM1 Van der Waals
MRI-1867 G166 2.53x53 TM2 Van der Waals
MRI-1867 F170 2.57x57 TM2 hydrophobic
MRI-1867 F170 2.57x57 TM2 aromatic (edge-to-face)
MRI-1867 V196 3.32x32 TM3 hydrophobic
MRI-1867 T197 3.33x33 TM3 Van der Waals
MRI-1867 F268 ECL2 hydrophobic
MRI-1867 W356 6.48x48 TM6 Van der Waals
MRI-1867 L359 6.51x51 TM6 hydrophobic
MRI-1867 M363 6.55x55 TM6 hydrophobic
MRI-1867 F379 7.35x34 TM7 aromatic (edge-to-face)
MRI-1867 A380 7.36x35 TM7 hydrophobic
MRI-1867 S383 7.39x38 TM7 Van der Waals
MRI-1867 M384 7.40x39 TM7 hydrophobic
MRI-1867 C386 7.42x41 TM7 hydrophobic

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ICL1 R S L R C ICL1ECL1 F H R K D ECL1ICL2 P L A Y K R I V ICL2ECL2 W N C E K L Q S V C S D I F P H I ECL2ICL3 T Q K S I I I H T S E D G K V Q V T R ICL3ECL3 K M ECL3N-term M K S I L D G L A D T T F R T I T T D L L Y V G S N D I Q Y E D I K G D M A S K L G Y F P Q K F P L T S F R G S P F Q E K M T A G D N P Q L V P A D Q V N I T E F Y N K S L S S F K E N E E N I Q C G E N F M D I E C F M V L N-termC-term S C E G T A Q P L D N S M G D S D C L H K H A N N A A S V H R A A E S C I K S T V K I A K V T M S V S T D T S A E A L C-term N P S Q Q L A I A V L S L T L G T F T V L E N L L V L C V I L H S R P S Y H F I G S L A V A D L L G S V I F V Y S F I D F H V S R N V F L F K L G G V T A S F T A S V G S L F L T A I D R Y I S I H R T R P K A V V A F C L M W T I A I V I A V L P L L G D E T Y L M F W I G V T S V L L L F I V Y A Y M Y I L W K A H S H A V R M I Q R G P D Q A R M D I R L A K T L V L I L V V L I I C W G P L L A I M V Y D V F G N K L I K T V F A F C S M L C L L N S T V N P I I Y A L R S K D F R S L R H A M F P
Helix box plot — Download: PNG | SVG L N E L V T F T G L T L S L V A I A L Q 1 G S L A V A D L L G S V I F V Y S F I D 2 L F L S G V S A T F S A T V G G L K F L 3 A V V A F C L M W T I A I V I A V L P L 4 Y A Y V I F L L L V S T V G I W F M L Y 5 V L I L V V L I I C W G P L L A I M V Y 6 I P N V T S N L L C L M S C F A F V T 7

GPCRdb(A)
GPCRdb(A)
CB1 receptor
TM1
1x35 1.35x35 I119
1x38 1.38x38 L122
1x39 1.39x39 S123
TM2
2x53 2.53x53 G166
2x57 2.57x57 F170
TM3
3x32 3.32x32 V196
3x33 3.33x33 T197
TM6
6x48 6.48x48 W356
6x51 6.51x51 L359
6x55 6.55x55 M363
TM7
7x34 7.35x34 F379
7x35 7.36x35 A380
7x38 7.39x38 S383
7x39 7.40x39 M384
7x41 7.42x41 C386