PDB
9BJK
Resolution
3.3 Å
Released
July 17, 2024
Receptor
μ
Class
A
Species
Mus musculus
Ligands
Compound 368
naloxone
Function
NAM
Antagonist
Reference
—
Compound 368 naloxone

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Ligand Amino Acid Generic Number Segment Interaction Type
Compound 368 Y75 1.39x39 TM1 hydrophobic
Compound 368 Q124 2.60x60 TM2 Van der Waals
Compound 368 Q124 2.60x60 TM2 polar (hydrogen bond)
Compound 368 N127 2.63x63 TM2 Van der Waals
Compound 368 Y128 2.64x64 TM2 Van der Waals
Compound 368 Y128 2.64x64 TM2 hydrophobic
Compound 368 W133 23.50x50 ECL1 hydrophobic
Compound 368 W133 23.50x50 ECL1 Van der Waals
Compound 368 V143 3.28x28 TM3 Van der Waals
Compound 368 V143 3.28x28 TM3 hydrophobic
Compound 368 I144 3.29x29 TM3 Van der Waals
Compound 368 I144 3.29x29 TM3 hydrophobic
Compound 368 D147 3.32x32 TM3 Van der Waals
naloxone W293 6.48x48 TM6 hydrophobic
naloxone I296 6.51x51 TM6 hydrophobic
naloxone H297 6.52x52 TM6 aromatic (face-to-edge)
naloxone V300 6.55x55 TM6 hydrophobic
naloxone W318 7.35x34 TM7 hydrophobic
Compound 368 H319 7.36x35 TM7 polar (hydrogen bond)
Compound 368 H319 7.36x35 TM7 Van der Waals
Compound 368 I322 7.39x38 TM7 hydrophobic
Compound 368 I322 7.39x38 TM7 Van der Waals
Compound 368 A323 7.40x39 TM7 hydrophobic
Compound 368 A323 7.40x39 TM7 Van der Waals
naloxone Y326 7.43x42 TM7 hydrophobic
Compound 368 Y326 7.43x42 TM7 Van der Waals
Compound 368 Y326 7.43x42 TM7 hydrophobic
Compound 368 T327 7.44x43 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A G P G N I S D C S D P L A P A S C S P A P G S W L N L S H V D G N Q S D P C G P N R T G L G G S H S L C P Q T G S P S N-termC-term P T S S T I E Q Q N S A R I R Q N T R E H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M V T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G N I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I V N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L I T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
Helix box plot — Download: PNG | SVG F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I V N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7

GPCRdb(A)
GPCRdb(A)
μ receptor
TM1
1x39 1.39x39 Y75
TM2
2x60 2.60x60 Q124
2x63 2.63x63 N127
2x64 2.64x64 Y128
ECL1
23x50 23.50x50 W133
TM3
3x28 3.28x28 V143
3x29 3.29x29 I144
3x32 3.32x32 D147
TM6
6x48 6.48x48 W293
6x51 6.51x51 I296
6x52 6.52x52 H297
6x55 6.55x55 V300
TM7
7x34 7.35x34 W318
7x35 7.36x35 H319
7x38 7.39x38 I322
7x39 7.40x39 A323
7x42 7.43x42 Y326
7x43 7.44x43 T327