PDB
9BLC
Resolution
3.3 Å
Released
April 16, 2025
Receptor
CT
Class
B1
Species
Homo sapiens
Ligand
Cagrilintide backbone (non-acylated)
Function
Agonist
Reference
10.1038/S41467-025-58680-Y

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Ligand Amino Acid Generic Number Segment Interaction Type
Cagrilintide backbone (non-acylated) W79 N-term hydrophobic
Cagrilintide backbone (non-acylated) D101 N-term polar (charge-assisted hydrogen bond)
Cagrilintide backbone (non-acylated) F102 N-term Van der Waals
Cagrilintide backbone (non-acylated) F102 N-term hydrophobic
Cagrilintide backbone (non-acylated) H121 N-term Van der Waals
Cagrilintide backbone (non-acylated) W128 N-term polar (hydrogen bond)
Cagrilintide backbone (non-acylated) W128 N-term Van der Waals
Cagrilintide backbone (non-acylated) S129 N-term Van der Waals
Cagrilintide backbone (non-acylated) S129 N-term polar (hydrogen bond with backbone)
Cagrilintide backbone (non-acylated) S129 N-term polar (hydrogen bond)
Cagrilintide backbone (non-acylated) Y131 N-term Van der Waals
Cagrilintide backbone (non-acylated) Y131 N-term hydrophobic
Cagrilintide backbone (non-acylated) F137 1.28x28 TM1 aromatic (edge-to-face)
Cagrilintide backbone (non-acylated) F137 1.28x28 TM1 Van der Waals
Cagrilintide backbone (non-acylated) L142 1.33x33 TM1 Van der Waals
Cagrilintide backbone (non-acylated) L142 1.33x33 TM1 hydrophobic
Cagrilintide backbone (non-acylated) A145 1.36x36 TM1 hydrophobic
Cagrilintide backbone (non-acylated) A145 1.36x36 TM1 Van der Waals
Cagrilintide backbone (non-acylated) Y146 1.37x37 TM1 polar (hydrogen bond)
Cagrilintide backbone (non-acylated) L148 1.39x39 TM1 Van der Waals
Cagrilintide backbone (non-acylated) Y149 1.40x40 TM1 hydrophobic
Cagrilintide backbone (non-acylated) Y149 1.40x40 TM1 Van der Waals
Cagrilintide backbone (non-acylated) V206 ECL1 hydrophobic
Cagrilintide backbone (non-acylated) V206 ECL1 Van der Waals
Cagrilintide backbone (non-acylated) P207 ECL1 Van der Waals
Cagrilintide backbone (non-acylated) P207 ECL1 polar (hydrogen bond with backbone)
Cagrilintide backbone (non-acylated) V212 ECL1 Van der Waals
Cagrilintide backbone (non-acylated) H226 3.36x36 TM3 polar (hydrogen bond)
Cagrilintide backbone (non-acylated) M230 3.40x40 TM3 polar (hydrogen bond)
Cagrilintide backbone (non-acylated) Y234 3.44x44 TM3 Van der Waals
Cagrilintide backbone (non-acylated) Y234 3.44x44 TM3 hydrophobic
Cagrilintide backbone (non-acylated) N288 ECL2 Van der Waals
Cagrilintide backbone (non-acylated) L291 45.52x52 ECL2 hydrophobic
Cagrilintide backbone (non-acylated) L291 45.52x52 ECL2 Van der Waals
Cagrilintide backbone (non-acylated) V293 ECL2 Van der Waals
Cagrilintide backbone (non-acylated) V293 ECL2 hydrophobic
Cagrilintide backbone (non-acylated) E294 ECL2 Van der Waals
Cagrilintide backbone (non-acylated) H296 ECL2 polar (hydrogen bond)
Cagrilintide backbone (non-acylated) L298 5.36x37 TM5 Van der Waals
Cagrilintide backbone (non-acylated) Y299 5.37x38 TM5 polar (hydrogen bond)
Cagrilintide backbone (non-acylated) Y299 5.37x38 TM5 Van der Waals
Cagrilintide backbone (non-acylated) H302 5.40x40 TM5 polar (hydrogen bond)
Cagrilintide backbone (non-acylated) F356 6.53x53 TM6 hydrophobic
Cagrilintide backbone (non-acylated) F356 6.53x53 TM6 Van der Waals
Cagrilintide backbone (non-acylated) P360 ECL3 Van der Waals
Cagrilintide backbone (non-acylated) P360 ECL3 polar (hydrogen bond with backbone)
Cagrilintide backbone (non-acylated) W361 ECL3 Van der Waals
Cagrilintide backbone (non-acylated) W361 ECL3 hydrophobic
Cagrilintide backbone (non-acylated) Y372 7.38x37 TM7 Van der Waals
Cagrilintide backbone (non-acylated) M376 7.42x41 TM7 Van der Waals
Cagrilintide backbone (non-acylated) H377 7.43x42 TM7 Van der Waals

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ICL1 R S L G ICL1ECL1 V P N G E L V R R D ECL1ICL2 A V F T E K Q ICL2ECL2 N D N C W L S V E T H L ECL2ICL3 E ICL3ECL3 R P S ECL3N-term M R F T F T S R C L A L F L L L N H P T P I L P A F S N Q T Y P T I E P K P F L Y V V G R K K M M D A Q Y K C Y D R M Q Q L P A Y Q G E G P Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D E K G V W F K H P E N N R T W S N Y N-termC-term P S N R S A R A A A A A A E A G D I P I Y I C H Q E L R N E P A N N Q G E E S A E I I P L N I I E Q E S S A C-term T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V K R F K I R W G V Q T T Q W A Q Q W N Q R R
Helix box plot — Download: PNG | SVG V L T F I S L S H G V I A L Y Y L V Y A 1 K N M F L T Y I L N S M I I I I H L V E 2 C L M W F Y N C A M M Y Q H F F H L I K 3 R L R W Y Y L G L W G F P L V P T T I H A 4 L F F F N V V L A A M V P G H I I Y L 5 M I L V P L L G I Q F V V F P W 6 T A V F F G Q F H I L S H M V Y D Y I 7

GPCRdb(A)
GPCRdb(B)
CT receptor
TM1
1x24 1.28x28 F137
1x29 1.33x33 L142
1x32 1.36x36 A145
1x33 1.37x37 Y146
1x35 1.39x39 L148
1x36 1.40x40 Y149
TM3
3x32 3.36x36 H226
3x36 3.40x40 M230
3x40 3.44x44 Y234
ECL2
45x52 45.52x52 L291
TM5
5x41 5.36x37 L298
5x42 5.37x38 Y299
5x44 5.40x40 H302
TM6
6x48 6.53x53 F356
TM7
7x33 7.38x37 Y372
7x37 7.42x41 M376
7x38 7.43x42 H377