PDB
9BQJ
Resolution
3.3 Å
Released
Sept. 11, 2024
Receptor
μ
Class
A
Species
Mus musculus
Ligand
Function
RO-76
Agonist (partial)
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
RO-76 Q124 2.60x60 TM2 hydrophobic
RO-76 N127 2.63x63 TM2 Van der Waals
RO-76 V143 3.28x28 TM3 Van der Waals
RO-76 I144 3.29x29 TM3 hydrophobic
RO-76 D147 3.32x32 TM3 polar (charge-charge)
RO-76 Y148 3.33x33 TM3 hydrophobic
RO-76 M151 3.36x36 TM3 hydrophobic
RO-76 C217 45.50x50 ECL2 hydrophobic
RO-76 W293 6.48x48 TM6 hydrophobic
RO-76 W293 6.48x48 TM6 aromatic (edge-to-face)
RO-76 H297 6.52x52 TM6 Van der Waals
RO-76 V300 6.55x55 TM6 Van der Waals
RO-76 W318 7.35x34 TM7 Van der Waals
RO-76 I322 7.39x38 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 T T K Y R Q G S I D C T L T F S H ECL2ICL3 R M L S G ICL3ECL3 T I P E ECL3N-term M D S S A G P G N I S D C S D P L A P A S C S P A P G S W L N L S H V D G N Q S D P C G P N R T G L G G S H S L C P Q T G S P S N-termC-term P T S S T I E Q Q N S A R I R Q N T R E H P S T A N T V D R T N H Q L E N L E A E T A P L P C-term M V T A I T I M A L Y S I V C V V G L F G N F L V M Y V I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S V N Y L M G G N I L C K I V I S I D Y Y N M F T S I F T L C T M S V D R Y I A V C H T P R N A K I V N V C N W I L S S A I G L P V M F M A P T W Y W E N L L K I C V F I F A F I M P V L I I T V C Y G L M I L R L K S V S K E K D R N L R R I T R M V L V V V A V F I V C W T P I H I Y V I I K A L I T T F Q T V S W H F C I A L G Y T N S C L N P V L Y A F L D E N F R E F K R C F C I
Helix box plot — Download: PNG | SVG F N G F L G V V C V I S Y L A M I T I A 1 F N L A L A D A L A T S T L P F Q S V N 2 T C L T F I S T F M N Y Y D I S I V I K 3 A K I V N V C N W I L S S A I G L P V M 4 Y C V T I I L V P M I F A F I F V C I K L 5 L V V V A V F I V C W T P I H I Y V I I 6 V P N L C S N T Y G L A I C F H W S V 7

GPCRdb(A)
GPCRdb(A)
μ receptor
TM2
2x60 2.60x60 Q124
2x63 2.63x63 N127
TM3
3x28 3.28x28 V143
3x29 3.29x29 I144
3x32 3.32x32 D147
3x33 3.33x33 Y148
3x36 3.36x36 M151
ECL2
45x50 45.50x50 C217
TM6
6x48 6.48x48 W293
6x52 6.52x52 H297
6x55 6.55x55 V300
TM7
7x34 7.35x34 W318
7x38 7.39x38 I322