PDB
9C2F
Resolution
2.8 Å
Released
Oct. 2, 2024
Receptor
CaS
Class
C
Species
Homo sapiens
Ligands
D-tryptophan
Calcium
'54149
Function
Agonist
Agonist
PAM
Reference
—
D-tryptophan Calcium '54149

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Ligand Amino Acid Generic Number Segment Interaction Type
D-tryptophan W70 N-term aromatic (edge-to-face)
Calcium I81 N-term Van der Waals
Calcium I81 N-term polar (hydrogen bond with backbone)
Calcium N82 N-term Van der Waals
Calcium S84 N-term Van der Waals
Calcium S84 N-term polar (hydrogen bond with backbone)
Calcium L87 N-term Van der Waals
Calcium L87 N-term polar (hydrogen bond with backbone)
Calcium L88 N-term polar (hydrogen bond with backbone)
Calcium L88 N-term Van der Waals
D-tryptophan S147 N-term Van der Waals
D-tryptophan S147 N-term polar (hydrogen bond)
D-tryptophan S147 N-term polar (hydrogen bond with backbone)
D-tryptophan A168 N-term Van der Waals
D-tryptophan A168 N-term polar (hydrogen bond with backbone)
D-tryptophan S169 N-term Van der Waals
D-tryptophan S170 N-term Van der Waals
D-tryptophan S170 N-term polar (hydrogen bond)
D-tryptophan S170 N-term polar (hydrogen bond with backbone)
D-tryptophan Y218 N-term hydrophobic
D-tryptophan Y218 N-term Van der Waals
D-tryptophan E297 N-term polar (charge-assisted hydrogen bond)
D-tryptophan A298 N-term hydrophobic
D-tryptophan A298 N-term Van der Waals
'54149 Q681 3.33x33 TM3 Van der Waals
'54149 Q681 3.33x33 TM3 polar (hydrogen bond)
'54149 F684 3.36x36 TM3 Van der Waals
'54149 F684 3.36x36 TM3 aromatic (edge-to-face)
'54149 G685 3.37x37 TM3 Van der Waals
'54149 L773 5.40x40 TM5 Van der Waals
'54149 L773 5.40x40 TM5 hydrophobic
'54149 I777 5.44x44 TM5 Van der Waals
'54149 I777 5.44x44 TM5 hydrophobic
'54149 T780 5.47x47 TM5 Van der Waals
'54149 W818 6.50x50 TM6 hydrophobic
'54149 W818 6.50x50 TM6 Van der Waals
'54149 F821 6.53x53 TM6 Van der Waals
'54149 F821 6.53x53 TM6 aromatic (edge-to-face)
'54149 Y825 6.57x57 TM6 aromatic (face-to-edge)
'54149 Y825 6.57x57 TM6 Van der Waals
'54149 E837 7.32x33 TM7 polar (charge-assisted hydrogen bond)
'54149 I841 7.36x37 TM7 Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 T R N P I V K A T ICL1ECL1 G E P ECL1ICL2 E A K I P T S F H R K W W ICL2ECL2 P P S S Y R N Q E L E D E I I F I T C H E G S ECL2ICL3 P E N F ICL3ECL3 Y ECL3N-term M A F Y S C C W V L L A L T W H T S A Y G P D Q R A Q K K G D I I L G G L F P I H F G V A A K D Q D L K S R P E S V E C I R Y N F R G F R W L Q A M I F A I E E I N S S P A L L P N L T L G Y R I F D T C N T V S K A L E A T L S F V A Q N K I D S L N L D E F C N C S E H I P S T I A V V G A T G S G V S T A V A N L L G L F Y I P Q V S Y A S S S R L L S N K N Q F K S F L R T I P N D E H Q A T A M A D I I E Y F R W N W V G T I A A D D D Y G R P G I E K F R E E A E E R D I C I D F S E L I S Q Y S D E E E I Q H V V E V I Q N S T A K V I V V F S S G P D L E P L I K E I V R R N I T G K I W L A S E A W A S S S L I A M P Q Y F H V V G G T I G F A L K A G Q I P G F R E F L K K V H P R K S V H N G F A K E F W E E T F N C H L Q E G A K G P L P V D T F L R G H E E S G D R F S N S S T A F R P L C T G D E N I S S V E T P Y I D Y T H L R I S Y N V Y L A V Y S I A H A L Q D I Y T C L P G R G L F T N G S C A D I K K V E A W Q V L K H L R H L N F T N N M G E Q V T F D E C G D L V G N Y S I I N W H L S P E D G S I V F K E V G Y Y N V Y A K K G E R L F I N E E K I L W S G F S R E V P F S N C S R D C L A G T R K G I I E G E P T C C F E C V E C P D G E Y S D E T D A S A C N K C P D D F W S N E N H T S C I A K E I E F L S W T N-termC-term T A A H A F K V A A R A T L R R S N V S R K R S S S L G G S T G S T P S S S I S S K S N S E D P F P Q P E R Q K Q Q Q P L A L T Q Q E Q Q Q Q P L T L P Q Q Q R S Q Q Q P R C K Q K V I F G S G T V T F S L S F D E P Q K N A M A H R N S T H Q N S L E A Q K S S D T L T R H E P L L P L Q C G E T D L D L T V Q E T G L Q G P V G G D Q R P E V E D P E E L S P A L V V S S S Q S F V I S G G G S T V T E N V V N S C-term E P F G I A L T L F A V L G I F L T A F V L G V F I K F N R E L S Y L L L F S L L C C F S S S L F F I Q D W T C R L R Q P A F G I S F V L C I S C I L V K T N R V L L V F G L N L Q F L L V F L C T F M Q I V I C V I W L Y T A L M A L G F L I G Y T C L L A A I C F F F A F K S R K L N E A K F I T F S M L I F F I V W I S F I P A Y A S T G K F V S A V E V I A I L A A S F G L L A C I F F N K I Y I I L F K P S R E V R N T I E C S
Helix box plot — Download: PNG | SVG A T L F I G L V A F L T L A I G F P E 1 Y L L L F S L L C C F S S S L F F I 2 V L I C S I C L V F S I G F A P Q R L R 3 Q F L L V F L C T F M Q I V I C V I W L 4 A F F F C I A A L L C T Y G I L F G L A 5 T F S M L I F F I V W I S F I P A Y A S 6 A L L G F S A A L I A I V E V A S V F K 7

GPCRdb(A)
GPCRdb(C)
CaS receptor
TM3
3x29 3.33x33 Q681
3x32 3.36x36 F684
3x33 3.37x37 G685
TM5
5x40 5.40x40 L773
5x44 5.44x44 I777
5x47 5.47x47 T780
TM6
6x48 6.50x50 W818
6x51 6.53x53 F821
6x55 6.57x57 Y825
TM7
7x38 7.32x33 E837
7x42 7.36x37 I841