| Ligand | Amino Acid | Generic Number | Segment | Interaction Type |
|---|---|---|---|---|
| AZ-1729 | P43 | 2.38x38 | TM2 | Van der Waals |
| CHEMBL4176503 | F87 | 3.30x30 | TM3 | hydrophobic |
| CHEMBL4176503 | Y90 | 3.33x33 | TM3 | aromatic (edge-to-face) |
| AZ-1729 | W98 | 3.41x41 | TM3 | hydrophobic |
| AZ-1729 | A101 | 3.44x44 | TM3 | Van der Waals |
| AZ-1729 | A101 | 3.44x44 | TM3 | hydrophobic |
| AZ-1729 | G102 | 3.45x45 | TM3 | Van der Waals |
| AZ-1729 | I105 | 3.48x48 | TM3 | hydrophobic |
| AZ-1729 | E106 | 3.49x49 | TM3 | polar (charge-assisted hydrogen bond) |
| AZ-1729 | L109 | 3.52x52 | TM3 | Van der Waals |
| AZ-1729 | S120 | 34.56x56 | ICL2 | polar (hydrogen bond) |
| AZ-1729 | S120 | 34.56x56 | ICL2 | Van der Waals |
| AZ-1729 | Y125 | 4.41x41 | TM4 | hydrophobic |
| AZ-1729 | Y125 | 4.41x41 | TM4 | Van der Waals |
| AZ-1729 | I128 | 4.44x44 | TM4 | Van der Waals |
| AZ-1729 | A129 | 4.45x45 | TM4 | Van der Waals |
| AZ-1729 | A129 | 4.45x45 | TM4 | hydrophobic |
| AZ-1729 | V132 | 4.48x48 | TM4 | hydrophobic |
| CHEMBL4176503 | C141 | 4.57x57 | TM4 | hydrophobic |
| CHEMBL4176503 | V144 | 4.60x60 | TM4 | hydrophobic |
| CHEMBL4176503 | I145 | 4.61x61 | TM4 | hydrophobic |
| CHEMBL4176503 | Y165 | 45.51x51 | ECL2 | hydrophobic |
| CHEMBL4176503 | F168 | ECL2 | hydrophobic | |
| CHEMBL4176503 | V175 | 5.34x35 | TM5 | hydrophobic |
| CHEMBL4176503 | V176 | 5.35x36 | TM5 | hydrophobic |
| CHEMBL4176503 | V179 | 5.38x39 | TM5 | hydrophobic |
| CHEMBL4176503 | R180 | 5.39x40 | TM5 | polar (charge-assisted hydrogen bond) |
| CHEMBL4176503 | L183 | 5.42x43 | TM5 | Van der Waals |
| AZ-1729 | P191 | 5.50x50 | TM5 | polar (hydrogen bond with backbone) |
| AZ-1729 | P191 | 5.50x50 | TM5 | Van der Waals |
| AZ-1729 | V194 | 5.53x53 | TM5 | hydrophobic |
| AZ-1729 | V194 | 5.53x53 | TM5 | Van der Waals |
| CHEMBL4176503 | Y238 | 6.51x51 | TM6 | polar (hydrogen bond) |
| CHEMBL4176503 | R255 | 7.35x34 | TM7 | polar (charge-assisted hydrogen bond) |
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|
GPCRdb(A)
|
GPCRdb(A)
|
FFA2 receptor
|
|---|---|---|
| TM2 | ||
| 2x38 | 2.38x38 | P43 |
| TM3 | ||
| 3x30 | 3.30x30 | F87 |
| 3x33 | 3.33x33 | Y90 |
| 3x41 | 3.41x41 | W98 |
| 3x44 | 3.44x44 | A101 |
| 3x45 | 3.45x45 | G102 |
| 3x48 | 3.48x48 | I105 |
| 3x49 | 3.49x49 | E106 |
| 3x52 | 3.52x52 | L109 |
| ICL2 | ||
| 34x56 | 34.56x56 | S120 |
| TM4 | ||
| 4x41 | 4.41x41 | Y125 |
| 4x44 | 4.44x44 | I128 |
| 4x45 | 4.45x45 | A129 |
| 4x48 | 4.48x48 | V132 |
| 4x57 | 4.57x57 | C141 |
| 4x60 | 4.60x60 | V144 |
| 4x61 | 4.61x61 | I145 |
| ECL2 | ||
| 45x51 | 45.51x51 | Y165 |
| TM5 | ||
| 5x35 | 5.34x35 | V175 |
| 5x36 | 5.35x36 | V176 |
| 5x39 | 5.38x39 | V179 |
| 5x40 | 5.39x40 | R180 |
| 5x43 | 5.42x43 | L183 |
| 5x50 | 5.50x50 | P191 |
| 5x53 | 5.53x53 | V194 |
| TM6 | ||
| 6x51 | 6.51x51 | Y238 |
| TM7 | ||
| 7x34 | 7.35x34 | R255 |