| Ligand | Amino Acid | Generic Number | Segment | Interaction Type |
|---|---|---|---|---|
| EP-3945 | Y106 | 3.33x33 | TM3 | hydrophobic |
| EP-3945 | Y109 | 3.36x36 | TM3 | hydrophobic |
| EP-3945 | C164 | 4.64x64 | TM4 | polar (hydrogen bond with backbone) |
| EP-3945 | C164 | 4.64x64 | TM4 | Van der Waals |
| EP-3945 | F170 | ECL2 | hydrophobic | |
| EP-3945 | D179 | 5.37x38 | TM5 | polar (charge-assisted hydrogen bond) |
| EP-3945 | Q182 | 5.40x41 | TM5 | polar (hydrogen bond) |
| EP-3945 | Q182 | 5.40x41 | TM5 | Van der Waals |
| EP-3945 | A183 | 5.41x42 | TM5 | hydrophobic |
| EP-3945 | A183 | 5.41x42 | TM5 | Van der Waals |
| EP-3945 | S238 | 6.52x52 | TM6 | Van der Waals |
| EP-3945 | W241 | 6.55x55 | TM6 | Van der Waals |
| EP-3945 | W241 | 6.55x55 | TM6 | aromatic (face-to-face) |
| EP-3945 | F242 | 6.56x56 | TM6 | hydrophobic |
| EP-3945 | F242 | 6.56x56 | TM6 | Van der Waals |
| EP-3945 | Y245 | 6.59x59 | TM6 | polar (hydrogen bond) |
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|
GPCRdb(A)
|
GPCRdb(A)
|
MRGPRD
|
|---|---|---|
| TM3 | ||
| 3x33 | 3.33x33 | Y106 |
| 3x36 | 3.36x36 | Y109 |
| TM4 | ||
| 4x64 | 4.64x64 | C164 |
| TM5 | ||
| 5x38 | 5.37x38 | D179 |
| 5x41 | 5.40x41 | Q182 |
| 5x42 | 5.41x42 | A183 |
| TM6 | ||
| 6x52 | 6.52x52 | S238 |
| 6x55 | 6.55x55 | W241 |
| 6x56 | 6.56x56 | F242 |
| 6x59 | 6.59x59 | Y245 |