PDB
9EAH
Resolution
3.1 Å
Released
March 5, 2025
Receptor
AT1
Class
A
Species
Homo sapiens
Ligand
Function
OLMESARTAN
Antagonist
Reference
10.1073/PNAS.2423931122

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Ligand Amino Acid Generic Number Segment Interaction Type
OLMESARTAN I31 1.35x35 TM1 Van der Waals
OLMESARTAN Y35 1.39x39 TM1 polar (hydrogen bond)
OLMESARTAN Y35 1.39x39 TM1 polar (hydrogen bond)
OLMESARTAN F77 2.53x53 TM2 hydrophobic
OLMESARTAN W84 2.60x60 TM2 aromatic (edge-to-face)
OLMESARTAN W84 2.60x60 TM2 hydrophobic
OLMESARTAN Y87 2.63x63 TM2 Van der Waals
OLMESARTAN T88 2.64x64 TM2 Van der Waals
OLMESARTAN Y92 ECL1 hydrophobic
OLMESARTAN S105 3.29x29 TM3 Van der Waals
OLMESARTAN V108 3.32x32 TM3 hydrophobic
OLMESARTAN S109 3.33x33 TM3 Van der Waals
OLMESARTAN L112 3.36x36 TM3 hydrophobic
OLMESARTAN A163 4.60x61 TM4 Van der Waals
OLMESARTAN R167 ECL2 polar (hydrogen bond)
OLMESARTAN R167 ECL2 polar (charge-charge)
OLMESARTAN F182 45.52x52 ECL2 Van der Waals
OLMESARTAN K199 5.42x43 TM5 aromatic (pi-cation)
OLMESARTAN K199 5.42x43 TM5 hydrophobic
OLMESARTAN P1285 7.36x35 TM7 Van der Waals
OLMESARTAN I1288 7.39x38 TM7 hydrophobic
OLMESARTAN Y1292 7.43x42 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 M K L K ICL1ECL1 Y R W P F ECL1ICL2 P M K S R L R R ICL2ECL2 N V F F I E N T N I T V C A F H Y E S Q N S T ECL2ICL3 Y E I Q K N K ICL3ECL3 I I R ECL3N-term M I L N S S T E D G I K R I Q D D C P K A G R N-termC-term P P K A K S H S N L S T K M S T L S Y R P S D N V S S S T K K P A P C F E V E C-term H N Y I F V M I P T L Y S I I F V V G I F G N S L V V I V I Y F Y T V A S V F L L N L A L A D L C F L L T L P L W A V Y T A M E G N Y L C K I A S A S V S F N L Y A S V F L L T C L S I D R Y L A I V H T M L V A K V T C I I I W L L A G L A S L P A I I H R L P I G L G L T K N I L G F L F P F L I I L T S Y T L I W K A L K K A P R N D D I F K I I M A I V L F F F F S W I P H Q I F T F L D V L I Q L G D C R I A D I V D T A M P I T I C I A Y F N N C L N P L F Y G F L G K K F L Q I F K R Y L L K Y
Helix box plot — Download: PNG | SVG S N G F I G V V F I I S Y L T P I M V F 1 L N L A L A D L C F L L T L P L W A V Y 2 C T L L F V S A Y L N F S V S A S A I K 3 A K V T C I I I W L L A G L A S L P A 4 Y S T L I I L F P F L F G L I N K T L G L 5 M A I V L F F F F S W I P H Q I F T F L 6 L P N L C N N F Y A I C I T I P M A T 7

GPCRdb(A)
GPCRdb(A)
AT1 receptor
TM1
1x35 1.35x35 I31
1x39 1.39x39 Y35
TM2
2x53 2.53x53 F77
2x60 2.60x60 W84
2x63 2.63x63 Y87
2x64 2.64x64 T88
TM3
3x29 3.29x29 S105
3x32 3.32x32 V108
3x33 3.33x33 S109
3x36 3.36x36 L112
TM4
4x61 4.60x61 A163
ECL2
45x52 45.52x52 F182
TM5
5x43 5.42x43 K199
TM7
7x35 7.36x35 P285
7x38 7.39x38 I288
7x42 7.43x42 Y292