PDB
9EAI
Resolution
3.1 Å
Released
March 5, 2025
Receptor
AT1
Class
A
Species
Homo sapiens
Ligands
Function
Nanobody AT206
PAM
losartan
Antagonist
Reference
10.1073/PNAS.2423931122
Nanobody AT206 losartan

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Ligand Amino Acid Generic Number Segment Interaction Type
losartan Y35 1.39x39 TM1 hydrophobic
losartan F77 2.53x53 TM2 hydrophobic
losartan L81 2.57x57 TM2 Van der Waals
losartan W84 2.60x60 TM2 Van der Waals
losartan Y87 2.63x63 TM2 hydrophobic
Nanobody AT206 Y87 2.63x63 TM2 Van der Waals
Nanobody AT206 E91 2.67x67 TM2 Van der Waals
losartan Y92 ECL1 hydrophobic
Nanobody AT206 Y92 ECL1 hydrophobic
Nanobody AT206 R93 23.49x49 ECL1 Van der Waals
losartan S105 3.29x29 TM3 Van der Waals
losartan V108 3.32x32 TM3 hydrophobic
losartan S109 3.33x33 TM3 Van der Waals
losartan L112 3.36x36 TM3 hydrophobic
losartan A163 4.60x61 TM4 Van der Waals
losartan R167 ECL2 aromatic (pi-cation)
losartan R167 ECL2 polar (charge-charge)
losartan R167 ECL2 polar (hydrogen bond)
Nanobody AT206 R167 ECL2 polar (hydrogen bond)
Nanobody AT206 F170 ECL2 hydrophobic
Nanobody AT206 F170 ECL2 aromatic (edge-to-face)
Nanobody AT206 I172 ECL2 hydrophobic
Nanobody AT206 E173 ECL2 polar (charge-charge)
Nanobody AT206 E173 ECL2 hydrophobic
Nanobody AT206 E173 ECL2 polar (hydrogen bond)
Nanobody AT206 N174 ECL2 polar (hydrogen bond)
Nanobody AT206 N174 ECL2 hydrophobic
Nanobody AT206 N174 ECL2 polar (hydrogen bond)
Nanobody AT206 I177 ECL2 hydrophobic
Nanobody AT206 V179 ECL2 hydrophobic
Nanobody AT206 A181 45.51x51 ECL2 hydrophobic
Nanobody AT206 F182 45.52x52 ECL2 polar (hydrogen bond with backbone)
losartan F182 45.52x52 ECL2 Van der Waals
Nanobody AT206 F182 45.52x52 ECL2 hydrophobic
Nanobody AT206 H183 ECL2 polar (hydrogen bond)
Nanobody AT206 Y184 ECL2 hydrophobic
Nanobody AT206 Y184 ECL2 polar (hydrogen bond with backbone)
Nanobody AT206 E185 ECL2 Van der Waals
Nanobody AT206 S186 ECL2 Van der Waals
Nanobody AT206 P192 5.35x36 TM5 hydrophobic
Nanobody AT206 L195 5.38x39 TM5 Van der Waals
losartan L195 5.38x39 TM5 Van der Waals
losartan K199 5.42x43 TM5 hydrophobic
Nanobody AT206 K199 5.42x43 TM5 Van der Waals
losartan W1253 6.48x48 TM6 Van der Waals
Nanobody AT206 H1256 6.51x51 TM6 Van der Waals
Nanobody AT206 T1260 6.55x55 TM6 Van der Waals
Nanobody AT206 I1266 6.61x61 TM6 Van der Waals
Nanobody AT206 Q1267 6.62x62 TM6 Van der Waals
Nanobody AT206 A1277 7.28x27 TM7 Van der Waals
Nanobody AT206 D1278 7.29x28 TM7 polar (charge-charge)
Nanobody AT206 D1278 7.29x28 TM7 polar (hydrogen bond)
Nanobody AT206 D1281 7.32x31 TM7 polar (charge-charge)
Nanobody AT206 D1281 7.32x31 TM7 polar (hydrogen bond)
Nanobody AT206 M1284 7.35x34 TM7 hydrophobic
Nanobody AT206 P1285 7.36x35 TM7 hydrophobic
Nanobody AT206 I1288 7.39x38 TM7 hydrophobic
losartan I1288 7.39x38 TM7 hydrophobic
losartan Y1292 7.43x42 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 M K L K ICL1ECL1 Y R W P F ECL1ICL2 P M K S R L R R ICL2ECL2 N V F F I E N T N I T V C A F H Y E S Q N S T ECL2ICL3 Y E I Q K N K ICL3ECL3 I I R ECL3N-term M I L N S S T E D G I K R I Q D D C P K A G R N-termC-term P P K A K S H S N L S T K M S T L S Y R P S D N V S S S T K K P A P C F E V E C-term H N Y I F V M I P T L Y S I I F V V G I F G N S L V V I V I Y F Y T V A S V F L L N L A L A D L C F L L T L P L W A V Y T A M E G N Y L C K I A S A S V S F N L Y A S V F L L T C L S I D R Y L A I V H T M L V A K V T C I I I W L L A G L A S L P A I I H R L P I G L G L T K N I L G F L F P F L I I L T S Y T L I W K A L K K A P R N D D I F K I I M A I V L F F F F S W I P H Q I F T F L D V L I Q L G D C R I A D I V D T A M P I T I C I A Y F N N C L N P L F Y G F L G K K F L Q I F K R Y L L K Y
Helix box plot — Download: PNG | SVG S N G F I G V V F I I S Y L T P I M V F 1 L N L A L A D L C F L L T L P L W A V Y 2 C T L L F V S A Y L N F S V S A S A I K 3 A K V T C I I I W L L A G L A S L P A 4 Y S T L I I L F P F L F G L I N K T L G L 5 M A I V L F F F F S W I P H Q I F T F L 6 L P N L C N N F Y A I C I T I P M A T 7

GPCRdb(A)
GPCRdb(A)
AT1 receptor
TM1
1x39 1.39x39 Y35
TM2
2x53 2.53x53 F77
2x57 2.57x57 L81
2x60 2.60x60 W84
2x63 2.63x63 Y87
2x67 2.67x67 E91
ECL1
23x49 23.49x49 R93
TM3
3x29 3.29x29 S105
3x32 3.32x32 V108
3x33 3.33x33 S109
3x36 3.36x36 L112
TM4
4x61 4.60x61 A163
ECL2
45x51 45.51x51 A181
45x52 45.52x52 F182
TM5
5x36 5.35x36 P192
5x39 5.38x39 L195
5x43 5.42x43 K199
TM6
6x48 6.48x48 W253
6x51 6.51x51 H256
6x55 6.55x55 T260
6x61 6.61x61 I266
6x62 6.62x62 Q267
TM7
7x27 7.28x27 A277
7x28 7.29x28 D278
7x31 7.32x31 D281
7x34 7.35x34 M284
7x35 7.36x35 P285
7x38 7.39x38 I288
7x42 7.43x42 Y292