PDB
9EBI
Resolution
3.6 Å
Released
Aug. 20, 2025
Receptor
A3
Class
A
Species
Homo sapiens
Ligand
piclidenoson
Function
Agonist
Reference
10.1038/S41467-025-62872-X

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Ligand Amino Acid Generic Number Segment Interaction Type
piclidenoson L90 3.32x32 TM3 hydrophobic
piclidenoson L91 3.33x33 TM3 hydrophobic
piclidenoson T94 3.36x36 TM3 Van der Waals
piclidenoson T94 3.36x36 TM3 polar (hydrogen bond)
piclidenoson H95 3.37x37 TM3 Van der Waals
piclidenoson F168 45.52x52 ECL2 aromatic (face-to-face)
piclidenoson F168 45.52x52 ECL2 Van der Waals
piclidenoson V169 ECL2 Van der Waals
piclidenoson V169 ECL2 hydrophobic
piclidenoson M172 ECL2 polar (hydrogen bond with backbone)
piclidenoson M172 ECL2 Van der Waals
piclidenoson R173 5.34x36 TM5 Van der Waals
piclidenoson M174 5.35x37 TM5 Van der Waals
piclidenoson M174 5.35x37 TM5 hydrophobic
piclidenoson M177 5.38x40 TM5 Van der Waals
piclidenoson W243 6.48x48 TM6 Van der Waals
piclidenoson W243 6.48x48 TM6 hydrophobic
piclidenoson L246 6.51x51 TM6 hydrophobic
piclidenoson L246 6.51x51 TM6 Van der Waals
piclidenoson N250 6.55x55 TM6 polar (hydrogen bond)
piclidenoson N250 6.55x55 TM6 Van der Waals
piclidenoson N250 6.55x55 TM6 polar (hydrogen bond)
piclidenoson I253 6.58x58 TM6 hydrophobic
piclidenoson L264 7.35x34 TM7 Van der Waals
piclidenoson I268 7.39x38 TM7 Van der Waals
piclidenoson I268 7.39x38 TM7 hydrophobic
piclidenoson S271 7.42x41 TM7 polar (hydrogen bond)
piclidenoson H272 7.43x42 TM7 Van der Waals
piclidenoson H272 7.43x42 TM7 polar (hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 P S L Q ICL1ECL1 I T I ECL1ICL2 T V R Y K R V T ICL2ECL2 W N M K L T S E Y H R N V T F L S C Q F V S V M ECL2ICL3 S N S K ICL3ECL3 G E V ECL3N-term M P N N S T A L N-termC-term L D T S I E K N S E C-term S L A N V T Y I T M E I F I G L C A I V G N V L V I C V V K L N T T T F Y F I V S L A L A D I A V G V L V M P L A I V V S L G H F Y S C L F M T C L L L I F T H A S I M S L L A I A V D R Y L R V K L T H R R I W L A L G L C W L V S F L V G L T P M F G R M D Y M V Y F S F L T W I F I P L V V M C A I Y L D I F Y I I R N K L S L N L E T G A F Y G R E F K T A K S L F L V L F L F A L S W L P L S I I N C I I Y F N P Q L V L Y M G I L L S H A N S M M N P I V Y A Y K I K K Y L L C V V D S F K E T I L K A C H P S
Helix box plot — Download: PNG | SVG V N G V I A C L G I F I E M T I Y T V N 1 V S L A L A D I A V G L V V M P L A I V V 2 A L L S M I S A H T F I L L L C T M F L 3 I W L A L G L C W L V S F L V G L T P M 4 Y I A C M V V L P I F I W T L F S F Y V M Y 5 F L V L F L F A L S W L P L S I I N C I 6 I P N M M S N A H S L L I G M Y L V L 7

GPCRdb(A)
GPCRdb(A)
A3 receptor
TM3
3x32 3.32x32 L90
3x33 3.33x33 L91
3x36 3.36x36 T94
3x37 3.37x37 H95
ECL2
45x52 45.52x52 F168
TM5
5x36 5.34x36 R173
5x37 5.35x37 M174
5x40 5.38x40 M177
TM6
6x48 6.48x48 W243
6x51 6.51x51 L246
6x55 6.55x55 N250
6x58 6.58x58 I253
TM7
7x34 7.35x34 L264
7x38 7.39x38 I268
7x41 7.42x41 S271
7x42 7.43x42 H272