PDB
9EE5
Resolution
2.9 Å
Released
Sept. 3, 2025
Receptor
DP1
Class
A
Species
Homo sapiens
Ligand
Function
ONO2550289
Inverse agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
ONO2550289 N18 N-term Van der Waals
ONO2550289 M22 N-term hydrophobic
ONO2550289 G23 1.39x39 TM1 Van der Waals
ONO2550289 L26 1.42x42 TM1 Van der Waals
ONO2550289 D72 2.50x50 TM2 Van der Waals
ONO2550289 G75 2.53x53 TM2 Van der Waals
ONO2550289 K76 2.54x54 TM2 hydrophobic
ONO2550289 L79 2.57x57 TM2 hydrophobic
ONO2550289 S80 2.58x58 TM2 polar (hydrogen bond)
ONO2550289 F108 3.28x28 TM3 Van der Waals
ONO2550289 M112 3.32x32 TM3 Van der Waals
ONO2550289 F115 3.35x35 TM3 hydrophobic
ONO2550289 G116 3.36x36 TM3 Van der Waals
ONO2550289 S119 3.39x39 TM3 Van der Waals
ONO2550289 W182 ECL2 hydrophobic
ONO2550289 R310 7.40x39 TM7 polar (charge-charge)
ONO2550289 R310 7.40x39 TM7 polar (hydrogen bond)
ONO2550289 L312 7.42x41 TM7 Van der Waals
ONO2550289 S313 7.43x42 TM7 polar (hydrogen bond)
ONO2550289 I315 7.45x45 TM7 hydrophobic
ONO2550289 S316 7.46x46 TM7 Van der Waals
ONO2550289 I317 7.47x47 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 G L G W C S R R P L R P L P ICL1ECL1 R S L R V L A ECL1ICL2 P F F Y R R H I ICL2ECL2 F G K F V Q Y C P G T W C F I Q M V H E E G S L S V ECL2ICL3 C A E P R A D G R E ICL3ECL3 D V K E K N ECL3N-term M K S P F Y R C Q N T T S V E K G N N-termC-term R P L R Y R S R C S N S T N M E S S L C-term S A V M G G V L F S T G L L G N L L A L G L L A R S S V F Y M L V C G L T V T D L L G K C L L S P V V L A A Y A Q N P A L D N S L C Q A F A F F M S F F G L S S T L Q L L A M A L E C W L S L G H T L R L G A L V A P V V S A F S L A F C A L P F M G L G Y S V L Y S S L M A L L V L A T V L C N L G A M R N L Y A M H R R L Q R H P R S C T R D A S P Q P L E E L D H L L L L A L M T V L F T M C S L P V I Y R A Y Y G A F K R T S E E A E D L R A L R F L S V I S I V D P W I F I I F R S P F F H V F R I K I F I
Helix box plot — Download: PNG | SVG L N G L L G T S F L V G G M V A S 1 C G L T V T D L L G K C L L S P V V L A 2 A L L Q L T S S L G F F S M F F A F A Q 3 G A L V A P V V S A F S L A F C A L P F 4 G L N C L V T A L V L L A M L S S Y L V 5 A L M T V L F T M C S L P V I Y R A Y Y 6 W P D V I S I V S L F R L A R L D E A 7

GPCRdb(A)
GPCRdb(A)
DP1 receptor
TM1
1x39 1.39x39 G23
1x42 1.42x42 L26
TM2
2x50 2.50x50 D72
2x53 2.53x53 G75
2x54 2.54x54 K76
2x57 2.57x57 L79
2x58 2.58x58 S80
TM3
3x28 3.28x28 F108
3x32 3.32x32 M112
3x35 3.35x35 F115
3x36 3.36x36 G116
3x39 3.39x39 S119
TM7
7x39 7.40x39 R310
7x41 7.42x41 L312
7x42 7.43x42 S313
7x45 7.45x45 I315
7x46 7.46x46 S316
7x47 7.47x47 I317