PDB
9EKH
Resolution
2.9 Å
Released
Sept. 3, 2025
Receptor
DP1
Class
A
Species
Homo sapiens
Ligand
Function
ONO3030297
Inverse agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
ONO3030297 K16 N-term polar (charge-charge)
ONO3030297 S19 1.35x35 TM1 Van der Waals
ONO3030297 G23 1.39x39 TM1 Van der Waals
ONO3030297 L26 1.42x42 TM1 Van der Waals
ONO3030297 D72 2.50x50 TM2 Van der Waals
ONO3030297 G75 2.53x53 TM2 Van der Waals
ONO3030297 K76 2.54x54 TM2 Van der Waals
ONO3030297 L79 2.57x57 TM2 hydrophobic
ONO3030297 S80 2.58x58 TM2 polar (hydrogen bond)
ONO3030297 V83 2.61x61 TM2 hydrophobic
ONO3030297 L84 2.62x62 TM2 Van der Waals
ONO3030297 F108 3.28x28 TM3 Van der Waals
ONO3030297 M112 3.32x32 TM3 Van der Waals
ONO3030297 F115 3.35x35 TM3 Van der Waals
ONO3030297 G116 3.36x36 TM3 Van der Waals
ONO3030297 S119 3.39x39 TM3 Van der Waals
ONO3030297 W182 ECL2 hydrophobic
ONO3030297 W182 ECL2 aromatic (edge-to-face)
ONO3030297 W182 ECL2 polar (hydrogen bond)
ONO3030297 R310 7.40x39 TM7 polar (charge-charge)
ONO3030297 R310 7.40x39 TM7 polar (hydrogen bond)
ONO3030297 L312 7.42x41 TM7 Van der Waals
ONO3030297 S313 7.43x42 TM7 polar (hydrogen bond)
ONO3030297 I315 7.45x45 TM7 hydrophobic
ONO3030297 S316 7.46x46 TM7 Van der Waals
ONO3030297 I317 7.47x47 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 G L G W C S R R P L R P L P ICL1ECL1 R S L R V L A ECL1ICL2 P F F Y R R H I ICL2ECL2 F G K F V Q Y C P G T W C F I Q M V H E E G S L S V ECL2ICL3 C A E P R A D G R E ICL3ECL3 D V K E K N ECL3N-term M K S P F Y R C Q N T T S V E K G N N-termC-term R P L R Y R S R C S N S T N M E S S L C-term S A V M G G V L F S T G L L G N L L A L G L L A R S S V F Y M L V C G L T V T D L L G K C L L S P V V L A A Y A Q N P A L D N S L C Q A F A F F M S F F G L S S T L Q L L A M A L E C W L S L G H T L R L G A L V A P V V S A F S L A F C A L P F M G L G Y S V L Y S S L M A L L V L A T V L C N L G A M R N L Y A M H R R L Q R H P R S C T R D A S P Q P L E E L D H L L L L A L M T V L F T M C S L P V I Y R A Y Y G A F K R T S E E A E D L R A L R F L S V I S I V D P W I F I I F R S P F F H V F R I K I F I
Helix box plot — Download: PNG | SVG L N G L L G T S F L V G G M V A S 1 C G L T V T D L L G K C L L S P V V L A 2 A L L Q L T S S L G F F S M F F A F A Q 3 G A L V A P V V S A F S L A F C A L P F 4 G L N C L V T A L V L L A M L S S Y L V 5 A L M T V L F T M C S L P V I Y R A Y Y 6 W P D V I S I V S L F R L A R L D E A 7

GPCRdb(A)
GPCRdb(A)
DP1 receptor
TM1
1x35 1.35x35 S19
1x39 1.39x39 G23
1x42 1.42x42 L26
TM2
2x50 2.50x50 D72
2x53 2.53x53 G75
2x54 2.54x54 K76
2x57 2.57x57 L79
2x58 2.58x58 S80
2x61 2.61x61 V83
2x62 2.62x62 L84
TM3
3x28 3.28x28 F108
3x32 3.32x32 M112
3x35 3.35x35 F115
3x36 3.36x36 G116
3x39 3.39x39 S119
TM7
7x39 7.40x39 R310
7x41 7.42x41 L312
7x42 7.43x42 S313
7x45 7.45x45 I315
7x46 7.46x46 S316
7x47 7.47x47 I317