PDB
9IIX
Resolution
2.9 Å
Released
July 24, 2024
Receptor
TAS2R14
Class
T2
Species
Homo sapiens
Ligand
compound 28.1 [PMID: 36847646]
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
compound 28.1 [PMID: 36847646] I62 2.57x57 TM2 polar (hydrogen bond)
compound 28.1 [PMID: 36847646] S65 2.60x60 TM2 polar (hydrogen bond)
compound 28.1 [PMID: 36847646] F76 ECL1 polar (hydrogen bond)
compound 28.1 [PMID: 36847646] F82 3.25x25 TM3 polar (hydrogen bond)
compound 28.1 [PMID: 36847646] L85 3.28x28 TM3 polar (hydrogen bond)
compound 28.1 [PMID: 36847646] T86 3.29x29 TM3 polar (hydrogen bond)
compound 28.1 [PMID: 36847646] W89 3.32x32 TM3 Van der Waals
compound 28.1 [PMID: 36847646] W89 3.32x32 TM3 aromatic (face-to-edge)
compound 28.1 [PMID: 36847646] G104 3.47x47 TM3 Van der Waals
compound 28.1 [PMID: 36847646] Y107 3.50x50 TM3 polar (hydrogen bond)
compound 28.1 [PMID: 36847646] F108 3.51x51 TM3 Van der Waals
compound 28.1 [PMID: 36847646] F108 3.51x51 TM3 hydrophobic
compound 28.1 [PMID: 36847646] S176 5.36x37 TM5 Van der Waals
compound 28.1 [PMID: 36847646] I179 5.39x40 TM5 polar (hydrogen bond)
compound 28.1 [PMID: 36847646] V180 5.40x41 TM5 Van der Waals
compound 28.1 [PMID: 36847646] S194 5.54x54 TM5 polar (hydrogen bond)
compound 28.1 [PMID: 36847646] S194 5.54x54 TM5 polar (hydrogen bond)
compound 28.1 [PMID: 36847646] M197 5.57x57 TM5 Van der Waals
compound 28.1 [PMID: 36847646] M197 5.57x57 TM5 hydrophobic
compound 28.1 [PMID: 36847646] F198 5.58x58 TM5 aromatic (face-to-edge)
compound 28.1 [PMID: 36847646] F198 5.58x58 TM5 polar (hydrogen bond)
compound 28.1 [PMID: 36847646] L201 5.61x61 TM5 polar (hydrogen bond)
compound 28.1 [PMID: 36847646] G229 6.34x34 TM6 polar (hydrogen bond with backbone)
compound 28.1 [PMID: 36847646] G229 6.34x34 TM6 Van der Waals
compound 28.1 [PMID: 36847646] S232 6.37x37 TM6 polar (hydrogen bond)
compound 28.1 [PMID: 36847646] V233 6.38x38 TM6 polar (hydrogen bond with backbone)
compound 28.1 [PMID: 36847646] V233 6.38x38 TM6 polar (hydrogen bond)
compound 28.1 [PMID: 36847646] F236 6.41x41 TM6 aromatic (face-to-edge)
compound 28.1 [PMID: 36847646] F236 6.41x41 TM6 Van der Waals
compound 28.1 [PMID: 36847646] Y240 6.45x45 TM6 polar (hydrogen bond)
compound 28.1 [PMID: 36847646] Y240 6.45x45 TM6 polar (hydrogen bond)
compound 28.1 [PMID: 36847646] S265 7.38x37 TM7 Van der Waals
compound 28.1 [PMID: 36847646] Q266 7.39x38 TM7 Van der Waals
compound 28.1 [PMID: 36847646] G269 7.42x41 TM7 Van der Waals
compound 28.1 [PMID: 36847646] H276 7.49x49 TM7 polar (hydrogen bond)
compound 28.1 [PMID: 36847646] L280 7.53x53 TM7 Van der Waals

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ICL1 R K I ICL1ECL1 P A L F A ECL1ICL2 N F S N S I F L Y L K W ICL2ECL2 A S I N G Y R R N K T C S S D S S N F T R F S S L ECL2ICL3 K I S G D A S T K A ICL3ECL3 E E ECL3C-term G E P S G H K E F R E S S C-term M G G V I K S I F T F V L I V E F I I G N L G N S F I A L V N C I D W V K G S S V D R I L T A L A I S R I S L V W L I F G S W C V S V F F T E K M F R M L T N I W T V I N H F S V W L A T G L G T F Y F L K I A R V K K V V L V L L L V T S V F L F L N I A L I N I H I N I V L T S T V F I F I P F T L S L A M F L L L I F S M W K H R K K M Q H T V H R G V K S V I T F F L L Y A I F S L S F F I S V W T S E R L N L I I L S Q V M G M A Y P S C H S C V L I L G N K K S L S L R Y L R Q A V L L W M F K D
Helix box plot — Download: PNG | SVG S N G L N G I I F E V I L V F T F I S K 1 T A L A I S R I S L V W L I F G S W C V 2 G T A L W V S F H N I V T W I N T L M R 3 V L V L L L V T S V F L F L N I A L I N 4 F M A L S L T F P I F I F V T S T L V I 5 V I T F F L L Y A I F S L S F F I S V W 6 C S H C S P Y A M G M V Q S L I I L N 7

GPCRdb(A)
GPCRdb(A)
TAS2R14
TM2
2x57 2.57x57 I62
2x60 2.60x60 S65
TM3
3x25 3.25x25 F82
3x28 3.28x28 L85
3x29 3.29x29 T86
3x32 3.32x32 W89
3x47 3.47x47 G104
3x50 3.50x50 Y107
3x51 3.51x51 F108
TM5
5x40 5.39x40 I179
5x41 5.40x41 V180
5x54 5.54x54 S194
5x57 5.57x57 M197
5x58 5.58x58 F198
5x61 5.61x61 L201
TM6
6x34 6.34x34 G229
6x37 6.37x37 S232
6x38 6.38x38 V233
6x41 6.41x41 F236
6x45 6.45x45 Y240
TM7
7x37 7.38x37 S265
7x38 7.39x38 Q266
7x41 7.42x41 G269
7x49 7.49x49 H276
7x53 7.53x53 L280