PDB
9IK8
Resolution
2.8 Å
Released
April 30, 2025
Receptor
SST1
Class
A
Species
Homo sapiens
Ligand
pasireotide
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
pasireotide S110 2.56x56 TM2 polar (hydrogen bond with backbone)
pasireotide S110 2.56x56 TM2 Van der Waals
pasireotide F113 2.59x59 TM2 Van der Waals
pasireotide L114 2.60x60 TM2 polar (hydrogen bond)
pasireotide S117 2.63x63 TM2 polar (hydrogen bond)
pasireotide T118 2.64x64 TM2 Van der Waals
pasireotide V133 3.28x28 TM3 Van der Waals
pasireotide L134 3.29x29 TM3 Van der Waals
pasireotide L134 3.29x29 TM3 hydrophobic
pasireotide D137 3.32x32 TM3 polar (charge-assisted hydrogen bond)
pasireotide A138 3.33x33 TM3 Van der Waals
pasireotide M141 3.36x36 TM3 polar (hydrogen bond)
pasireotide F142 3.37x37 TM3 Van der Waals
pasireotide F142 3.37x37 TM3 hydrophobic
pasireotide C208 45.50x50 ECL2 polar (hydrogen bond)
pasireotide C208 45.50x50 ECL2 polar (hydrogen bond with backbone)
pasireotide N209 45.51x51 ECL2 polar (hydrogen bond)
pasireotide L220 5.35x36 TM5 polar (hydrogen bond with backbone)
pasireotide L220 5.35x36 TM5 Van der Waals
pasireotide V221 5.36x37 TM5 Van der Waals
pasireotide F223 5.38x39 TM5 hydrophobic
pasireotide F223 5.38x39 TM5 Van der Waals
pasireotide V224 5.39x40 TM5 hydrophobic
pasireotide V224 5.39x40 TM5 Van der Waals
pasireotide T227 5.42x43 TM5 polar (hydrogen bond)
pasireotide F287 6.51x51 TM6 polar (hydrogen bond)
pasireotide Y288 6.52x52 TM6 Van der Waals
pasireotide Q291 6.55x55 TM6 polar (hydrogen bond)
pasireotide Q291 6.55x55 TM6 polar (hydrogen bond with backbone)
pasireotide Q291 6.55x55 TM6 polar (hydrogen bond)
pasireotide Q291 6.55x55 TM6 polar (hydrogen bond)
pasireotide N294 6.58x58 TM6 Van der Waals
pasireotide V295 6.59x59 TM6 hydrophobic
pasireotide V295 6.59x59 TM6 Van der Waals
pasireotide Q299 ECL3 polar (hydrogen bond with backbone)
pasireotide Q299 ECL3 Van der Waals
pasireotide A302 ECL3 hydrophobic
pasireotide A302 ECL3 Van der Waals
pasireotide S305 7.35x34 TM7 polar (hydrogen bond)
pasireotide V309 7.39x38 TM7 polar (hydrogen bond)
pasireotide Y313 7.43x42 TM7 polar (hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 A K M K ICL1ECL1 R H W P F ECL1ICL2 P I K A A R Y R ICL2ECL2 R T A A N S D G T V A C N M L M P E ECL2ICL3 W Q Q R K R S ICL3ECL3 E Q D ECL3N-term M F P N G T A S S P S S S P S P S P G S C G E G G G S R G P G A G A A D G M E E P G R N A S Q N G T L S N-termC-term L S W M D N A A E E P V D Y Y A T A L K S R A Y S V E D F Q P E N L E S G G V F R N G T C T S R I T T L C-term E G Q G S A I L I S F I Y S V V C L V G L C G N S M V I Y V I L R Y T A T N I Y I L N L A I A D E L L M L S V P F L V T S T L L G A L L C R L V L S V D A V N M F T S I Y C L T V L S V D R Y V A V V H R P T V A K V V N L G V W V L S L L V I L P I V V F S P A Q R W L V G F V L Y T F L M G F L L P V G A I C L C Y V L I I A K M R M V A L K A G E R K I T L M V M M V V M V F V I C W M P F Y V V Q L V N V F A D A T V S Q L S V I L G Y A N S C A N P I L Y G F L S D N F Q R F K R S I L C
Helix box plot — Download: PNG | SVG S N G C L G V L C V V S Y I F S I L I A 1 L N L A I A D E L L M L S V P F L V T S 2 V T L C Y I S T F M N V A D V S L V L R 3 A K V V N L G V W V L S L L V I L P I 4 Y C L C I A G V P L L F G M L F T Y L V F 5 M M V V M V F V I C W M P F Y V V Q L V 6 I P N A C S N A Y G L I V S L Q S V T 7

GPCRdb(A)
GPCRdb(A)
SST1 receptor
TM2
2x56 2.56x56 S110
2x59 2.59x59 F113
2x60 2.60x60 L114
2x63 2.63x63 S117
2x64 2.64x64 T118
TM3
3x28 3.28x28 V133
3x29 3.29x29 L134
3x32 3.32x32 D137
3x33 3.33x33 A138
3x36 3.36x36 M141
3x37 3.37x37 F142
ECL2
45x50 45.50x50 C208
45x51 45.51x51 N209
TM5
5x36 5.35x36 L220
5x37 5.36x37 V221
5x39 5.38x39 F223
5x40 5.39x40 V224
5x43 5.42x43 T227
TM6
6x51 6.51x51 F287
6x52 6.52x52 Y288
6x55 6.55x55 Q291
6x58 6.58x58 N294
6x59 6.59x59 V295
TM7
7x34 7.35x34 S305
7x38 7.39x38 V309
7x42 7.43x42 Y313