PDB
9IV1
Resolution
3.0 Å
Released
Feb. 12, 2025
Receptor
ADGRD1
Class
B2
Species
Homo sapiens
Ligand
dihydrotestosterone
Function
Agonist
Reference
10.1016/J.CELL.2025.01.006

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Ligand Amino Acid Generic Number Segment Interaction Type
dihydrotestosterone L619 2.64x64 TM2 hydrophobic
dihydrotestosterone H640 3.37x37 TM3 Van der Waals
dihydrotestosterone H640 3.37x37 TM3 polar (hydrogen bond)
dihydrotestosterone F643 3.40x40 TM3 hydrophobic
dihydrotestosterone F643 3.40x40 TM3 Van der Waals
dihydrotestosterone W705 45.51x51 ECL2 hydrophobic
dihydrotestosterone W705 45.51x51 ECL2 Van der Waals
dihydrotestosterone L706 45.52x52 ECL2 Van der Waals
dihydrotestosterone L708 ECL2 hydrophobic
dihydrotestosterone L708 ECL2 Van der Waals
dihydrotestosterone I713 5.36x36 TM5 hydrophobic
dihydrotestosterone I713 5.36x36 TM5 Van der Waals
dihydrotestosterone F716 5.39x39 TM5 hydrophobic
dihydrotestosterone F716 5.39x39 TM5 Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

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Snake plot — Download: PNG | SVG
ICL1 S T I R ICL1ECL1 E P G ECL1ICL2 V F G S E D S ICL2ECL2 M D S Y G T S N N C W L S L A S ECL2ICL3 I H G ICL3ECL3 N G ECL3N-term M E K L L R L C C W Y S W L L L F Y Y N F Q V R G V Y S R S Q D H P G F Q V L A S A S H Y W P L E N V D G I H E L Q D T T G D I V E G K V N K G I Y L K E E K G V T L L Y Y G R Y N S S C I S K P E Q C G P E G V T F S F F W K T Q G E Q S R P I P S A Y G G Q V I S N G F K V C S S G G R G S V E L Y T R D N S M T W E A S F S P P G P Y W T H V L F T W K S K E G L K V Y V N G T L S T S D P S G K V S R D Y G E S N V N L V I G S E Q D Q A K C Y E N G A F D E F I I W E R A L T P D E I A M Y F T A A I G K H A L L S S T L P S L F M T S T A S P V M P T D A N-termC-term T S S S A R T S N A K P F H S D L M N G T R P G M A S T K L S P W D K S S H S A H R V D L S A V C-term A R G H Q V A L S S I S Y V G C S L S V L C L V A T L V T F A V L S S V N Q R Y H I H A N L S F A V L V A Q V L L L I S F R L T T P C Q V M A V L L H Y F F L S A F A W M L V E G L H L Y S M V I K K H R Y Y Y G M G W G F P L L I C I I S L S F A G A I W A F V A P A L F V I V V N I G I L I A V T R V I S Q I S A D N Y K D P S A F K L T A K A V A V L L P I L G T S W V F G V L A V C A V V F Q Y M F A T L N S L Q G L F I F L F H C L L N S E F K H W S L V R A A K T K V
Helix box plot — Download: PNG | SVG V L C L V S L S C G V Y S I S S L A V Q 1 A N L S F A V L V A Q V L L L I S F R L 2 V L M W A F A S L F F Y H L L V A M V Q 3 K H R Y Y Y G G M W G F P L L I C I I S L 4 L I G I N V V I V F L A P A V F A W I A 5 A V L L P I L G T S W V F G V L A V 6 L F I F L G Q L S N L T A F M Y Q F V 7

GPCRdb(A)
GPCRdb(B)
ADGRD1
TM2
2x57 2.64x64 L619
TM3
3x33 3.37x37 H640
3x36 3.40x40 F643
ECL2
45x51 45.51x51 W705
45x52 45.52x52 L706
TM5
5x40 5.36x36 I713
5x43 5.39x39 F716