PDB
9IVG
Resolution
3.0 Å
Released
Nov. 27, 2024
Receptor
GLP-1
Class
B1
Species
Homo sapiens
Ligand
Function
glucagon-like peptide 1-(9-36)
Agonist (partial)
Reference
10.1016/J.APSB.2024.09.002

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Ligand Amino Acid Generic Number Segment Interaction Type
glucagon-like peptide 1-(9-36) S31 N-term polar (hydrogen bond)
glucagon-like peptide 1-(9-36) L32 N-term hydrophobic
glucagon-like peptide 1-(9-36) L32 N-term polar (hydrogen bond with backbone)
glucagon-like peptide 1-(9-36) T35 N-term polar (hydrogen bond)
glucagon-like peptide 1-(9-36) D67 N-term Van der Waals
glucagon-like peptide 1-(9-36) E68 N-term Van der Waals
glucagon-like peptide 1-(9-36) Y69 N-term hydrophobic
glucagon-like peptide 1-(9-36) L89 N-term hydrophobic
glucagon-like peptide 1-(9-36) P90 N-term Van der Waals
glucagon-like peptide 1-(9-36) W91 N-term Van der Waals
glucagon-like peptide 1-(9-36) L118 N-term hydrophobic
glucagon-like peptide 1-(9-36) L123 N-term hydrophobic
glucagon-like peptide 1-(9-36) L141 1.36x36 TM1 polar (hydrogen bond with backbone)
glucagon-like peptide 1-(9-36) L141 1.36x36 TM1 hydrophobic
glucagon-like peptide 1-(9-36) L142 1.37x37 TM1 hydrophobic
glucagon-like peptide 1-(9-36) L144 1.39x39 TM1 Van der Waals
glucagon-like peptide 1-(9-36) Y145 1.40x40 TM1 hydrophobic
glucagon-like peptide 1-(9-36) Y148 1.43x43 TM1 aromatic (pi-cation)
glucagon-like peptide 1-(9-36) K197 2.67x67 TM2 polar (charge-charge)
glucagon-like peptide 1-(9-36) D198 2.68x68 TM2 Van der Waals
glucagon-like peptide 1-(9-36) L201 2.71x71 TM2 hydrophobic
glucagon-like peptide 1-(9-36) K202 2.72x72 TM2 hydrophobic
glucagon-like peptide 1-(9-36) Y205 2.75x75 TM2 aromatic (edge-to-face)
glucagon-like peptide 1-(9-36) Y205 2.75x75 TM2 hydrophobic
glucagon-like peptide 1-(9-36) A208 2.78x78 TM2 hydrophobic
glucagon-like peptide 1-(9-36) Q211 ECL1 Van der Waals
glucagon-like peptide 1-(9-36) W214 ECL1 hydrophobic
glucagon-like peptide 1-(9-36) L388 7.43x42 TM7 Van der Waals

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ICL1 R H L H ICL1ECL1 T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V L ICL2ECL2 D E G C W T R N S ECL2ICL3 M ICL3ECL3 D E H A R ECL3N-term M A G A P G P L R L A L L L L G M V G R A G P R P Q G A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S K R G E R S S P N-termC-term S M K P L K C P T S S L S S G A T A G S S M Y T A T C Q A S C S C-term E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L I Q R V Q L E S W E R E H L H D S
Helix box plot — Download: PNG | SVG V L A S F S L A Y G V T Y I I Y L F L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F R L Y V S G I W G V P L L F V V P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F V M 6 I A V M L G Q F S T F S L E T F L K I 7

GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM1
1x32 1.36x36 L141
1x33 1.37x37 L142
1x35 1.39x39 L144
1x36 1.40x40 Y145
1x39 1.43x43 Y148
TM2
2x60 2.67x67 K197
2x61 2.68x68 D198
2x64 2.71x71 L201
2x65 2.72x72 K202
2x68 2.75x75 Y205
TM7
7x38 7.43x42 L388