PDB
9IZG
Resolution
3.0 Å
Released
Jan. 1, 2025
Receptor
LPA1
Class
A
Species
Homo sapiens
Ligand
LPA
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
LPA K39 N-term polar (charge-assisted hydrogen bond)
LPA T109 ECL1 polar (hydrogen bond)
LPA T109 ECL1 polar (hydrogen bond)
LPA T113 23.50x50 ECL1 polar (hydrogen bond)
LPA R124 3.28x28 TM3 polar (charge-assisted hydrogen bond)
LPA Q125 3.29x29 TM3 polar (hydrogen bond)
LPA Q125 3.29x29 TM3 Van der Waals
LPA D129 3.33x33 TM3 Van der Waals
LPA M198 ECL2 Van der Waals
LPA Y202 ECL2 hydrophobic
LPA Y202 ECL2 Van der Waals
LPA L207 5.40x40 TM5 hydrophobic
LPA L207 5.40x40 TM5 Van der Waals
LPA W210 5.43x43 TM5 Van der Waals
LPA W210 5.43x43 TM5 hydrophobic
LPA G274 6.51x51 TM6 Van der Waals
LPA L278 6.55x55 TM6 hydrophobic
LPA L278 6.55x55 TM6 Van der Waals
LPA E293 7.35x34 TM7 polar (charge-assisted hydrogen bond)
LPA K294 7.36x35 TM7 polar (charge-assisted hydrogen bond)
LPA L297 7.39x38 TM7 hydrophobic
LPA L297 7.39x38 TM7 Van der Waals

LPA

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Snake plot — Download: PNG | SVG
ICL1 R R F H ICL1ECL1 T G P N T R R L ECL1ICL2 M Q L H T R M ICL2ECL2 W N C I C D I E N C S N M A P L Y ECL2ICL3 R H S S ICL3ECL3 P Q C ECL3N-term M A A I S T S I P V I S Q P Q F T A M N E P Q C F Y N E S I A F F Y N R S G K H L A T E W N N-termC-term C Q R S E N P T G P T E G S D R S A S S L N H T I L A G V H S N D H S V V C-term T V S K L V M G L G I T V C I F I M L A N L L V M V A I Y V N F P I Y Y L M A N L A A A D F F A G L A Y F Y L M F N T V S T W L L R Q G L I D T S L T A S V A N L L A I A I E R H I T V F R S N R R V V V V I V V I W T M A I V M G A I P S V G S D S Y L V F W A I F N L V T F V V M V V L Y A H I F G Y V R Q R T M R M S G P R R N R D T M M S L L K T V V I V L G A F I I C W T P G L V L L L L D V C C D V L A Y E K F F L L L A E F N S A M N P I I Y S Y R D K E F R Q M S A T I L C
Helix box plot — Download: PNG | SVG L N A L M I F I C V T I G L G M V L K S 1 A N L A A A D F F A G L A Y F Y L M F N 2 A L L N A V S A T L S T D I L G Q R L L 3 V V V V I V V I W T M A I V M G A I P S 4 Y L V V M V V F T V L N F I A W F V L Y 5 V I V L G A F I I C W T P G L V L L L L 6 I P N M A S N F E A L L L F F K E Y A 7

GPCRdb(A)
GPCRdb(A)
LPA1 receptor
ECL1
23x50 23.50x50 T113
TM3
3x28 3.28x28 R124
3x29 3.29x29 Q125
3x33 3.33x33 D129
TM5
5x40 5.40x40 L207
5x43 5.43x43 W210
TM6
6x51 6.51x51 G274
6x55 6.55x55 L278
TM7
7x34 7.35x34 E293
7x35 7.36x35 K294
7x38 7.39x38 L297