PDB
9J87
Resolution
2.8 Å
Released
Feb. 25, 2026
Receptor
5-HT2A
Class
A
Species
Homo sapiens
Ligand
Function
5-MeOT
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
5-MeOT D155 3.32x32 TM3 polar (hydrogen bond)
5-MeOT D155 3.32x32 TM3 polar (charge-charge)
5-MeOT V156 3.33x33 TM3 hydrophobic
5-MeOT S159 3.36x36 TM3 Van der Waals
5-MeOT T160 3.37x37 TM3 polar (hydrogen bond)
5-MeOT L229 45.52x52 ECL2 Van der Waals
5-MeOT F234 5.38x39 TM5 hydrophobic
5-MeOT V235 5.39x40 TM5 Van der Waals
5-MeOT G238 5.42x43 TM5 Van der Waals
5-MeOT S242 5.46x461 TM5 Van der Waals
5-MeOT F339 6.51x51 TM6 hydrophobic
5-MeOT F340 6.52x52 TM6 hydrophobic
5-MeOT F340 6.52x52 TM6 aromatic (edge-to-face)
5-MeOT N343 6.55x55 TM6 polar (hydrogen bond)
5-MeOT V366 7.39x38 TM7 Van der Waals

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ICL1 K K L Q ICL1ECL1 Y R W P L ECL1ICL2 P I H H S R F N ICL2ECL2 D S K V F K E G S C L L A ECL2ICL3 G T R A K L A S F S F L P Q S S L S S E K L F Q R S I H R E P G S Y T G R R T ICL3ECL3 K E S C ECL3N-term M D I L C E E N T S L S S T T N S L M Q L N D D T R L Y S N D F N S G E A N T S D A F N W T V D S E N R T N L S C E G C L S P S C L S L N-termC-term Q Y K E N K K P L Q L I L V N T I P A L A Y K S S Q L Q M G Q K K N S K Q D A K T T D N D C S M V A L G K Q H S E E A S K D N S D G V N E K V S C V C-term L H L Q E K N W S A L L T A V V I I L T I A G N I L V I M A V S L E N A T N Y F L M S L A I A D M L L G F L V M P V S M L T I L Y G P S K L C A V W I Y L D V L F S T A S I M H L C A I S L D R Y V A I Q N S R T K A F L K I I A V W T I S V G I S M P I P V F G L Q D D D N F V L I G S F V S F F I P L T I M V I T Y F L T I K S L Q K E A T L C V S D L M Q S I S N E Q K A C K V L G I V F F L F V V M W C P F F I T N I M A V I C N E D V I G A L L N V F V W I G Y L S S A V N P L V Y T L F N K T F S R Y R S A Y I Q C
Helix box plot — Download: PNG | SVG I N G A I T L I I V V A T L L A S W N K 1 M S L A I A D M L L G L F V M P V S M L T 2 A C L H M I S A T S F L V D L Y I W V A 3 A F L K I I A V W T I S V G I S M P I 4 Y T I V M I T L P I F F S V F S G I L V F 5 G I V F F L F V V M W C P F F I T N I M 6 L P N V A S S L Y G I W V F V N L L A 7

GPCRdb(A)
GPCRdb(A)
5-HT2A receptor
TM3
3x32 3.32x32 D155
3x33 3.33x33 V156
3x36 3.36x36 S159
3x37 3.37x37 T160
ECL2
45x52 45.52x52 L229
TM5
5x39 5.38x39 F234
5x40 5.39x40 V235
5x43 5.42x43 G238
5x461 5.46x461 S242
TM6
6x51 6.51x51 F339
6x52 6.52x52 F340
6x55 6.55x55 N343
TM7
7x38 7.39x38 V366